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  2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation Cytoskeleton Cell Cycle/DNA Damage
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  4. Methylene blue hydrate

Methylene blue hydrate  (Synonyms: 亞甲藍(lán)水合物; Basic Blue 9 hydrate; CI-52015 hydrate; Methylthioninium chloride hydrate)

目錄號: HY-D0958
COA 產(chǎn)品使用指南

Methylene blue (Basic Blue 9) hydrate 是一種鳥苷酸環(huán)化酶 (sGC)，單胺氧化酶 A (MAO-A) 和 NO 合酶 (NOS) 抑制劑。Methylene blue hydrate 是一種血管加壓劑，在醫(yī)療中通常用作染料。Methylene blue hydrate 通過一氧化氮合成酶/鳥苷酸環(huán)化酶信號通路降低脈沖前抑制。Methylene blue hydrate 是一種氧化還原循環(huán)化合物，能夠穿過血腦屏障。Methylene blue hydrate 是Tau 聚集抑制劑。亞甲藍(lán)可減輕腦水腫，減弱小膠質(zhì)細(xì)胞活化，減少神經(jīng)炎癥。

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Methylene blue hydrate Chemical Structure

Methylene blue hydrate Chemical Structure

CAS No. : 122965-43-9

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Other Forms of Methylene blue hydrate:

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  • 生物活性

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生物活性

Methylene blue (Basic Blue 9) hydrate is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue hydrate through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue hydrate is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue hydrate is a Tau aggregation inhibitor. Methylene blue hydrate reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation[1][2][3].

體外研究
(In Vitro)

Methylene blue (Basic Blue 9) hydrate (4.5 μM; BV2 microglia) alters the immune profile of LPS-activated BV2 microglia and decreased the level of CD14, IL-1β, TNF-α, and CCL2 mRNA[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Methylene blue (Basic Blue 9) hydrate (50 and 100 mg/kg; i.p.; once, for 25 min; male NMRI mice) reduces absent prepulse inhibition[1].
Methylene blue hydrate (20 and 40 mg/kg; p.o.; daily, for 6 months; CaMKIIα-tTA transactivator mice) preserves cognition in mice expressing full-length pro-aggregant human Tau[2].
Methylene blue hydrate (2 mg/kg; i.v.; once, for 1 d; TBI-treated male BALB/c mice) reduces TBI-induced edema and neuroinflammation and reduces acute depression-like behavior[3].
Methylene blue hydrate (2 mg/kg; i.v.; once, for 1 d; TBI-treated male BALB/c mice) reduces the percentage of inflammatory factor[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male NMRI mice[1]
Dosage: 50 and 100 mg/kg
Administration: Intraperitoneal injection; once, for 25 minutes
Result: Reduced the prepulse inhibition and reduced the increase in locomotor activity caused by phencyclidine (PCP).
Animal Model: CaMKIIα-tTA transactivator mice[2]
Dosage: 20 and 40 mg/kg
Administration: Oral administration; daily, for 6 months
Result: Inhibited Tau aggregation in CaMKIIα-tTA transactivator mice.
Animal Model: TBI-treated male BALB/c mice[3]
Dosage: 2 mg/kg
Administration: Intravenous injection; once, for 1 day
Result: Decreased the level of CD14, IL-1β, TNF-α, and CCL2 mRNA.
Animal Model: TBI-treated male BALB/c mice[3]
Dosage: 2 mg/kg
Administration: Intravenous injection; once, for 1 day
Result: Reduced the percentage of myeloid (CD11b+/GR1+) cells, reduced IL-1β and enhanced IL-10 expression in microglia.
Clinical Trial
Formula

C16H18N3S.Cl.xH2O
CAS 號
性狀

固體

顏色

Light green to green

中文名稱

亞甲藍(lán)水合物
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

H2O 中的溶解度 : 2 mg/mL (超聲助溶 (<60°C))

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產(chǎn)品名稱：
Methylene blue hydrate
目錄號：
HY-D0958
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