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  2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease NF-κB Immunology/Inflammation JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. PPAR Reactive Oxygen Species STAT NF-κB Apoptosis
  4. Astaxanthin

Astaxanthin  (Synonyms: 蝦青素)

目錄號: HY-B2163 純度: ≥98.0%
COA 產(chǎn)品使用指南

Astaxanthin，紅色膳食類胡蘿卜素，是一種口服有效的強效抗氧化劑。Astaxanthin 可抑制 NF-κB，能在蛋白質(zhì)水平下調(diào)高血糖中的 VEGF。Astaxanthin 通過激活 PPARγ 并減少 STAT3 和相關(guān)通路蛋白的表達，發(fā)揮抗癌細胞增殖、增加凋亡以及削弱遷移和侵襲的活性。Astaxanthin 還具有神經(jīng)保護和抗炎活性可用于癌癥，糖尿病視網(wǎng)膜病變，心血管疾病等研究以及動物飼料的著色。

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Astaxanthin Chemical Structure

Astaxanthin Chemical Structure

CAS No. : 472-61-7

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥250
In-stock
5 mg ￥500
In-stock
10 mg ￥700
In-stock
25 mg ￥1204
In-stock
50 mg ￥1775
In-stock
100 mg ￥2650
In-stock
200 mg   詢價  
500 mg   詢價  

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Customer Review

Other Forms of Astaxanthin:

    Astaxanthin purchased from MCE. Usage Cited in: Exp Biol Med. 2023 Jan 23;15353702221147568.  [Abstract]

    Astaxanthin (ASTA) decreases levels of caspase 3 and caspase 9 in MLE-12 cells, which reveals that ASTA prevents apoptosis stimulated by LPS in MLE-12 cells.

    Astaxanthin purchased from MCE. Usage Cited in: Exp Biol Med. 2023 Jan 23;15353702221147568.  [Abstract]

    Astaxanthin (ASTA) inhibits apoptosis by targeting NF-κB signal pathway in MLE-12 cells.

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    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻

    生物活性

    Astaxanthin, the red dietary carotenoid, is an orally effective and potent antioxidant. Astaxanthin inhibits NF-κB and down-regulates VEGF in blood glucose. Astaxanthin exerts anti-cancer cell proliferation, increases apoptosis, impairs migration and invasion by activating PPARγ and reducing the expression of STAT3. Astaxanthin also has neuroprotective and anti-inflammatory activity and can be used in studies of cancer, diabetic retinopathy, cardiovascular disease, and in the coloring of animal feed[1][2][3][4][5].

    IC50 & Target[1][2][3][4]

    PPARγ

     

    STAT3

     

    體外研究
    (In Vitro)

    Astaxanthin (50、100、150、200 μM；48 小時) 抑制 DU145 細胞增殖 (IC50 值 <200 μM)[1]。
    Astaxanthin (200 μM；24 小時) 通過抑制增殖、增加細胞凋亡和削弱遷移和侵襲來降低 STAT3 和相關(guān)通路蛋白的表達（在蛋白質(zhì)和 mRNA 水平上）[1]
    蝦青素通過在高糖下在蛋白質(zhì)水平上下調(diào) VEGF 來保護 RPE 細胞免受異?；罨脱趸瘧ぃǜ咛钦T導）[2]。
    Astaxanthin (1-50 μM；72 小時) 以時間和劑量依賴性方式上調(diào) K562 細胞中 PPARγ 的蛋白質(zhì)表達[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Apoptosis Analysis[1]

    Cell Line: DU145 cells
    Concentration: 200 μM (pre-incubation)
    Incubation Time: 24 h
    Result: Increased the percentage of apoptotic cells from 8.5% to 13.1% (compared to blank control).

    Cell Migration Assay [1]

    Cell Line: DU145 cells
    Concentration: 200 μM
    Incubation Time: 24 h
    Result: Decreased the migration and invasion of DU145 cells (about 41% of cells could not pass from one chamber to another, and 36% cells could not pass through the transwell membrane as compared to the control group).

    Cell Proliferation Assay[2]

    Cell Line: ARPE-19 cells
    Concentration: 50 μM (pre-incubation)
    Incubation Time: 7 days
    Result: Significantly decreased cell proliferation exposed to high glucose.

    Western Blot Analysis[1]

    Cell Line: DU145 cells
    Concentration: 200 μM
    Incubation Time: 24 h
    Result: Reduced the expression of STAT3 at both protein and mRNA levels (downregulated the protein expression of JAK2, BCL-2 and NF-κB and upregulated the protein expression of BAX, Caspase3 and Caspase9).

    Western Blot Analysis[3]

    Cell Line: K562 cells
    Concentration: 1-50 μM
    Incubation Time: 72 h
    Result: Significantly promoted PPARγ protein expression in time- and dose-dependent manners.
    體內(nèi)研究
    (In Vivo)

    Astaxanthin（200 mg/kg；胃內(nèi)給藥；每天一次，持續(xù) 3 周）可抑制裸鼠 DU145 腫瘤異種移植瘤的生長[1]。
    Astaxanthin（125 或 500 mg/kg；動物喂養(yǎng)；7 天）可為大鼠提供顯著的心臟保護作用，并降低氧化應激[4]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Nude mice (approximately 20 g; DU145 tumor xenografts model)[1].
    Dosage: 200 mg/kg
    Administration: Intragastric administration; once daily for 3 weeks.
    Result: Exerted a significant inhibitory effect on tumor growth.
    Animal Model: Female C57BL/6 mice (7 weeks old)[4].
    Dosage: 125 or 500 mg/kg
    Administration: In animal feedings; 7 days.
    Result: Significantly reduced mean infarct size in the two treated groups (125 and 500 mg/kg) to 45.1% and 39.1%, respectively.
    Exhibited myocardial salvage of 26 and 36% for 125 and 500 mg/kg groups, respectively.
    Significantl reduced level of 9-HETE in a dose-dependent manner. 9-HETE is a regioisomer oxidation product of arachidonic acid believed to be a product of free radical-mediated oxidation.
    Clinical Trial
    分子量

    596.84

    Formula

    C40H52O4
    CAS 號
    性狀

    固體

    顏色

    Dark purple to black

    中文名稱

    蝦青素
    結(jié)構(gòu)分類
    初始來源

    Haematococcus pluvialis
    運輸條件

    Room temperature in continental US; may vary elsewhere.
    儲存方式

    -20°C, protect from light, stored under nitrogen

    *該產(chǎn)品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)用現(xiàn)配，即刻使用。

    溶解性數(shù)據(jù)
    細胞實驗： 

    DMSO 中的溶解度 : 2 mg/mL (3.35 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

    Acetone 中的溶解度 : < 1 mg/mL (insoluble)

    *Astaxanthin is usually formulated as a suspension.

    配制儲備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 1.6755 mL 8.3775 mL 16.7549 mL
    5 mM --- --- ---
    查看完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液；該產(chǎn)品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)用現(xiàn)配，即刻使用。

    • 摩爾計算器

    • 稀釋計算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動物實驗：

    以下溶解方案，請直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶。

    • 方案 一

      請依序添加每種溶劑： 0.5% CMC-Na/saline water

      Solubility: 3.33 mg/mL (5.58 mM); 懸濁液; 超聲加熱助溶

    • 方案 二

      請依序添加每種溶劑： 20% HP-β-CD in Saline

      Solubility: 3.33 mg/mL (5.58 mM); 懸濁液; 超聲加熱助溶

    動物溶解方案計算器
    請輸入動物實驗的基本信息：

    給藥劑量

    mg/kg

    動物的平均體重

    g

    每只動物的給藥體積

    μL

    動物數(shù)量

    只
    由于實驗過程有損耗，建議您多配一只動物的量
    計算結(jié)果
    工作液所需濃度 : mg/mL
    純度 & 產(chǎn)品資料

    純度: ≥98.0%

    參考文獻

    完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液；該產(chǎn)品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)用現(xiàn)配，即刻使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.6755 mL 8.3775 mL 16.7549 mL 41.8873 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    產(chǎn)品名稱：
    Astaxanthin
    目錄號：
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