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  2. Vitamin D Related/Nuclear Receptor Anti-infection Epigenetics
  3. Nuclear Hormone Receptor 4A/NR4A Parasite Histone Methyltransferase
  4. Amodiaquine

Amodiaquine  (Synonyms: Amodiaquin)

目錄號: HY-B1322A 純度: 99.98%
COA 產(chǎn)品使用指南 技術(shù)支持

Amodiaquine (Amodiaquin) 是一種4-氨基喹啉類抗瘧劑，是一種有效的具有口服活性的組胺 N-甲基轉(zhuǎn)移酶 (histamine N-methyltransferase) 抑制劑。Amodiaquine 也是一種 Nurr1 激動劑，可特異性結(jié)合 Nurr1 的配體結(jié)合域，EC50 為 ~20 μM?？寡鬃饔?。

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Amodiaquine Chemical Structure

Amodiaquine Chemical Structure

CAS No. : 86-42-0

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥1320
In-stock
5 mg ￥1200
In-stock
10 mg ￥1900
In-stock
50 mg ￥5700
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100 mg 現(xiàn)貨 詢價
200 mg   詢價  
500 mg   詢價  

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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect[1][2][3][4].

IC50 & Target

Plasmodium

 

Nurr1/NR4A2

 

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
BHK-21 CC50
52.09 μM
Compound: Amodiaquine
Cytotoxicity against BHK21 cells after 24 hrs by CellTiter-Glo luminescent assay
Cytotoxicity against BHK21 cells after 24 hrs by CellTiter-Glo luminescent assay
[PMID: 26771861]
CHO IC50
147.157 μM
Compound: Amodiaquine
Cytotoxicity against CHO cells by MTT assay
Cytotoxicity against CHO cells by MTT assay
[PMID: 26264839]
SH-SY5Y CC50
10 μM
Compound: AQ
Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay
Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay
[PMID: 29559198]
Vero CC50
> 50 μM
Compound: Amodiaquine
Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr
Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr
10.1101/2020.03.20.999730
Vero IC50
5.15 μM
Compound: Amodiaquine
Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr
Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr
10.1101/2020.03.20.999730
體外研究
(In Vitro)

Amodiaquine (10-20 μM; 4 hours) treatment suppresses LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner[1].
Amodiaquine (5 μM; 24 hours) significantly inhibits neurotoxin (6-OHDA-induced cell death in primary dopamine cells as examined by the number of TH+ neurons and dopamine uptake. The neuroprotective effect of Amodiaquine is also observed in rat PC12 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: Primary microglia
Concentration: 10 μM, 15 μM, 20 μM
Incubation Time: 4 hours
Result: Suppressed LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.
體內(nèi)研究
(In Vivo)

Amodiaquine (40 mg/kg; intraperitoneal injection; daily; for 3 days; male ICR mice) treatment diminishes perihematomal activation of microglia/macrophages and astrocytes. Amodiaquine also suppresses ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice (8-10?weeks of age) induced ntracerebral hemorrhage (ICH)[2]
Dosage: 40 mg/kg
Administration: Intraperitoneal injection; daily; for 3 days
Result: Diminished perihematomal activation of microglia/macrophages and astrocytes.
Clinical Trial
分子量

355.86

Formula

C20H22ClN3O
CAS 號
性狀

固體

顏色

White to light yellow

中文名稱

阿莫地喹
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 66.67 mg/mL (187.35 mM; ultrasonic and adjust pH to 3 with 1M HCl; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.8101 mL 14.0505 mL 28.1009 mL
5 mM 0.5620 mL 2.8101 mL 5.6202 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.98%

參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8101 mL 14.0505 mL 28.1009 mL 70.2523 mL
5 mM 0.5620 mL 2.8101 mL 5.6202 mL 14.0505 mL
10 mM 0.2810 mL 1.4050 mL 2.8101 mL 7.0252 mL
15 mM 0.1873 mL 0.9367 mL 1.8734 mL 4.6835 mL
20 mM 0.1405 mL 0.7025 mL 1.4050 mL 3.5126 mL
25 mM 0.1124 mL 0.5620 mL 1.1240 mL 2.8101 mL
30 mM 0.0937 mL 0.4683 mL 0.9367 mL 2.3417 mL
40 mM 0.0703 mL 0.3513 mL 0.7025 mL 1.7563 mL
50 mM 0.0562 mL 0.2810 mL 0.5620 mL 1.4050 mL
60 mM 0.0468 mL 0.2342 mL 0.4683 mL 1.1709 mL
80 mM 0.0351 mL 0.1756 mL 0.3513 mL 0.8782 mL
100 mM 0.0281 mL 0.1405 mL 0.2810 mL 0.7025 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Amodiaquine
目錄號：
HY-B1322A
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