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  2. Anti-infection
  3. Parasite
  4. Piperonyl butoxide

Piperonyl butoxide  (Synonyms: 增效醚; ENT-14250)

目錄號: HY-B1198 純度: ≥98.0%
COA 產(chǎn)品使用指南 技術(shù)支持

Piperonyl butoxide (ENT-14250) 是農(nóng)藥增效劑和食品添加劑。Piperonyl butoxide 會對小鼠的生殖、發(fā)育和行為等產(chǎn)生不利影響。Piperonyl butoxide 可在小鼠肝細胞中激活 c-Jun 和 ATF-2。對大鼠和小鼠而言，Piperonyl butoxide 是一種肝癌致癌物。

MCE 的所有產(chǎn)品僅用作科學研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務(wù)

Piperonyl butoxide Chemical Structure

Piperonyl butoxide Chemical Structure

CAS No. : 51-03-6

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2.  同一機構(gòu)（單位）同一產(chǎn)品試用裝僅限申領(lǐng)一次，同一機構(gòu)（單位）一年內(nèi)

     可免費申領(lǐng)三個不同產(chǎn)品的試用裝。

3.  試用裝只面向終端客戶。

規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥385
In-stock
100 mg ￥350
In-stock
500 mg ￥800
In-stock
1 g   詢價  
5 g   詢價  

* Please select Quantity before adding items.

Customer Review

Other Forms of Piperonyl butoxide:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

                                            
                                                

                                                    

	                	
	                    

	                        生物活性
	                        
	                            

	                            	

                                    
                                    
	                                
										Piperonyl butoxide (ENT-14250) is a pesticide synergist and food additive. Piperonyl butoxide has adverse effects on reproduction, development and behavior in mice. Piperonyl butoxide can activate c-Jun and ATF-2 in mouse hepatocytes. Piperonyl butoxide is a liver cancer carcinogen in rats and mice[1][2][3].
									
									
                                    
									

	                            

	                        		
	                    

	                    
                        
                        
                        
                        
                        
                        
                            

                                體外研究
(In Vitro)		
                                
                                    

                                        
                                            
Piperonyl butoxide (25 μg/mL；24 小時) 在小鼠肝細胞中誘導(dǎo) ATF-2 的磷酸化[1]。

                                            
                                                
MCE has not independently confirmed the accuracy of these methods. They are for reference only.

                                            
                                        
                                        
                                        
                                            
                                            

                                                
                                                
                                            

                                            
                                        

                                        
                                            

                                                
                                                    

                                                        
Western Blot Analysis[1]

                                                        

                                                            

                                                                Cell Line:
                                                                Mouse immortalized hepatocyte cell line TLR-3
                                                            

                                                            

                                                                Concentration:
                                                                25 μg/mL
                                                            

                                                            

                                                                Incubation Time:
                                                                24 h
                                                            

                                                            

                                                                Result:
                                                                Significantly increased the phosphorylation level of ATF-2.

                                                            

                                                        

                                                    

                                                
                                            

                                            
                                        
                                    

                                		
                            

                        
                        
                        
                            

                                體內(nèi)研究
(In Vivo)		
                                
                                    

                                        
                                            
Piperonyl butoxide (飲食中含 0.6%；飼料給藥；48 小時) 可在小鼠肝細胞中激活 c-Jun 和 ATF-2，這可能會促進小鼠肝癌早期細胞增殖[1]。

Piperonyl butoxide (飲食中含 0.025-0.4%；飼料給藥；8 周) 會對雌性小鼠的探索行為產(chǎn)生不利影響[2]。

在雌性 C57BL/6J 小鼠中藥代動力學分析[4]





Route
Dose
CL (mL/h)
V (mL)
Fgavage
Fchow
IIV CL 
IIV V
IIV Fgavage
IIV Fchow
Proportional Residual Error



 
i.g.
22.22 mg/kg
83.3 

791
1 FIXED
/
106.8 
96.7
0
/
58.0



 
Daily diet
0.09% diet
83.3 FIXED  

791 FIXED 
1 FIXED 
0.409
0
0
145
103
82.6












                                            
                                        
                                        
                                        
                                        

                                                        

                                                            Animal Model:
                                                            Male ICR mice aged 5 weeks old[1] 
                                                        

                                                        

                                                            Dosage:
                                                            Diet containing 0.6%
                                                        

                                                        

                                                            Administration:
                                                            Feed administration; 48 h
                                                        

                                                        

                                                            Result:
                                                            Elevated the level of liver nuclear proteins that bind to an AP-1 consensus oligonucleotide at 24 h of administration. 

Induced c-Jun phosphorylation within 8 h of administration, and phosphorylated ATF-2 was detected after 24 h of administration.		
                                                        

                                                    

                                                

                                            
                                                

                                                    

                                                        

                                                            Animal Model:
                                                            Female mice (Crl: CD1) aged 5 weeks old[2]
                                                        

                                                        

                                                            Dosage:
                                                            Diet containing 0.025%, 0.1%, and 0.4%
                                                        

                                                        

                                                            Administration:
                                                            Feed administration; from 5 to 12 weeks of age.
                                                        

                                                        

                                                            Result:
                                                            Had no significant effect on the average body weight of female mice through the experimental periods. 

Had no significant effect on the performance of multiple-T water maze at 10 weeks of age. 

Reduced the average speed in a dose-dependent manner in exploratory behaviour examination at 8 weeks of age. 

Shortened the total exploration distance in a dose-dependent manner and decreased the average speed in exploratory behavior examination at 11 weeks of age.		
                                                        

                                                    

                                                

                                            
                                        

                                        
                                            

                                                
                                                
                                            

                                        
                                        
                                    

                                
                            
                        
	                    
	                    
	                        Clinical Trial
                            
                                

                                    

                                    

                                    

                                        
                                        
                                    

                                

                            
                        
	                    
                        
                        
                        
                            
                                分子量
                                
                                    

                                        

                                            
                                                338.44
                                            
                                            
                                        

                                    

                                
                            
                        
                        
                        
                        
                        
                        
                        
                        
                        
                            
                                Formula
                                
                                    
C19H30O5

                                
                            
                        
                        
                            
                                CAS 號
                                
                                    

                                        
                                            51-03-6
                                        
                                    

                                
                            
                        
                        
                        
                            
                                性狀
                                
                                    

                                        

                                            油狀物
                                        

                                    

                                
                            
                        
                        
                            
                                顏色
                                
                                    

                                        

                                            Colorless to light yellow
                                        

                                    

                                
                            
                        
                        
                        
                        
                        
                        
                            
                                中文名稱
                                
                                    
增效醚

                                
                            
                        
                        
                            
                        
                        
                        
                        
                        
                            
                                運輸條件
                                

                                    
                                    
                                        
Room temperature in continental US; may vary elsewhere.

                                    
                                        
                                

                            
                        
                        
                        
                        
                            儲存方式
                            
                                

                                    
                                    
                                        

                                            
                                                

                                                    Pure form
                                                    -20°C
                                                    3 years
                                                

                                            
                                                

                                                    
                                                    4°C
                                                    2 years
                                                

                                            
                                                

                                                    In solvent
                                                    -80°C
                                                    6 months
                                                

                                            
                                                

                                                    
                                                    -20°C
                                                    1 month
                                                

                                            
                                        

                                    
                                    
                                

                            
                        
                        
                        
                        
                            
                            
                                
                                
                                    溶解性數(shù)據(jù)
                                    
                                        
                                            
細胞實驗： 

                                            

                                                
                                                    
Ethanol 中的溶解度 : 100 mg/mL (295.47 mM; 超聲助溶)

                                                
                                                    
DMSO 中的溶解度 : 100 mg/mL (295.47 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

                                                
                                                    
H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

                                                
                                                
                                                
                                            

                                        

                                        
                                        
                                            

                                                

                                                    
配制儲備液

                                                    

                                                        

                                                            

                                                                
                                                                    濃度
                                                                    溶劑體積
                                                                    質(zhì)量
                                                                
                                                                1 mg
                                                                5 mg
                                                                10 mg
                                                            

                                                            
                                                        

                                                        

                                                            
                                                                

                                                                    
                                                                        
                                                                            1 mM
                                                                        
                                                                    
                                                                        
                                                                            2.9547 mL
                                                                        
                                                                    
                                                                        
                                                                            14.7737 mL
                                                                        
                                                                    
                                                                        
                                                                            29.5473 mL
                                                                        
                                                                    
                                                                

                                                            
                                                                

                                                                    
                                                                        
                                                                            5 mM
                                                                        
                                                                    
                                                                        
                                                                            0.5909 mL
                                                                        
                                                                    
                                                                        
                                                                            2.9547 mL
                                                                        
                                                                    
                                                                        
                                                                            5.9095 mL
                                                                        
                                                                    
                                                                

                                                            
                                                                
                                                            



                                                        

                                                    

                                                

                                                

                                                    
                                                

                                            


                                            

                                                
                                                    
                                                    
                                                        查看完整儲備液配制表
                                                    

                                                
                                            

                                            

                                                
                                                    

                                                        *
                                                        請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。
                                                    

                                                
                                                
                                            

                                        
                                        
                                        

                                            

                                                
    
                                                    
  • 摩爾計算器
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)





    

        

            質(zhì)量
            
            

            
        

        =
        

            濃度
            
            

            
        

        ×
        

            體積
            
            

            
        

        ×
        

            分子量 *
            
        

    





















































    
    
        
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    
This equation is commonly abbreviated as: C1V1 = C2V2





    

        

            濃度 (start)
            
            

            
            
C1

        

        ×
        

            體積 (start)
            
            

            
            
V1

        

        =
        

            濃度 (final)
            
            

            
            
C2

        

        ×
        

            體積 (final)
            
            

            
            
V2

        

    


































































    
    
        
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動物實驗：

                                            

                                                
                                                    

                                                        

                                                            請根據(jù)您的 實驗動物和給藥方式 選擇適當?shù)娜芙夥桨浮?                                                        

                                                        

                                                            以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：

                                                            ——為保證實驗結(jié)果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當保存；體內(nèi)實驗的工作液，建議您現(xiàn)用現(xiàn)配，當天使用；

                                                            以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶