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  2. Anti-infection Cell Cycle/DNA Damage
  3. Parasite Antifolate
  4. Proguanil hydrochloride

Proguanil hydrochloride  (Synonyms: 鹽酸氯胍)

目錄號: HY-B0806A 純度: 99.21%
COA 產(chǎn)品使用指南 技術支持

Proguanil hydrochloride是一種抗瘧前體，被代謝為活性代謝物環(huán)鳥苷 (HY-12784)。Proguanil hydrochloride是一種二氫葉酸還原酶 (DHFR) 抑制劑。

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Proguanil hydrochloride Chemical Structure

Proguanil hydrochloride Chemical Structure

CAS No. : 637-32-1

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規(guī)格 價格 是否有貨 數(shù)量
5 mg ￥312
In-stock
10 mg ￥500
In-stock
25 mg ￥1100
In-stock
50 mg ￥1800
In-stock
100 mg ￥2880
In-stock
200 mg   詢價  
500 mg   詢價  

* Please select Quantity before adding items.

Customer Review

Other Forms of Proguanil hydrochloride:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Proguanil hydrochloride, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor[1][2].

IC50 & Target

Plasmodium

 

體外研究
(In Vitro)

Proguanil per se has only weak antimalarial activity in vitro (IC50=2.4-19 μM), and its effectiveness depends on the active metabolite Cycloguanil (IC50=0.5-2.5 nM). The Cycloguanil is a dihydrofolate reductase (DHFR) inhibitor. The combination of Atovaquone and Proguanil is synergistic in vitro. Both drugs also have activity against gametocytes and pre-erythrocytic (hepatic) stages of malaria parasites[1].
Proguanil acts as a biguanide rather than as its metabolite Cycloguanil (a parasite dihydrofolate reductase [DHFR] inhibitor) to enhance the Atovaquone effect. Proguanil-mediated enhancement is specific for Atovaquone, since the effects of other mitochondrial electron transport inhibitors, such as Myxothiazole and Antimycin, are not altered by inclusion of Proguanil[2].
5-HT3 receptor responses are reversibly inhibited by Proguanil, the metabolite 4-chlorophenyl-1-biguanide (CPB) and the active metabolite Cycloguanil (CG), with an IC50 of 1.81, 1.48 and 4.36 μM, respectively[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Proguanil (p.o.; 2.9 mg/kg body weight; daily for 5 days and 6 weeks respectively) shows mild degenerative changes for five days, while shows severe degenerative changes for six weeks in wistar strain albino rats[4].
Serum testosterone level is significantly decreased for proguanil treatment rats[4].
Administration of Malarone (Atovaquone and Proguanil) to experimentally B. gibsoni infected two dogs in chronic stage and three dogs in acute stage results in decrease in parasitemia, and clinical improvements are observed[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

290.19

Formula

C11H17Cl2N5
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

鹽酸氯胍
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 125 mg/mL (430.75 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 3.4460 mL 17.2301 mL 34.4602 mL
5 mM 0.6892 mL 3.4460 mL 6.8920 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料
參考文獻

Proguanil hydrochloride 相關分類

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4460 mL 17.2301 mL 34.4602 mL 86.1505 mL
5 mM 0.6892 mL 3.4460 mL 6.8920 mL 17.2301 mL
10 mM 0.3446 mL 1.7230 mL 3.4460 mL 8.6150 mL
15 mM 0.2297 mL 1.1487 mL 2.2973 mL 5.7434 mL
20 mM 0.1723 mL 0.8615 mL 1.7230 mL 4.3075 mL
25 mM 0.1378 mL 0.6892 mL 1.3784 mL 3.4460 mL
30 mM 0.1149 mL 0.5743 mL 1.1487 mL 2.8717 mL
40 mM 0.0862 mL 0.4308 mL 0.8615 mL 2.1538 mL
50 mM 0.0689 mL 0.3446 mL 0.6892 mL 1.7230 mL
60 mM 0.0574 mL 0.2872 mL 0.5743 mL 1.4358 mL
80 mM 0.0431 mL 0.2154 mL 0.4308 mL 1.0769 mL
100 mM 0.0345 mL 0.1723 mL 0.3446 mL 0.8615 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Proguanil hydrochloride
目錄號：
HY-B0806A
需求量：