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  2. Cell Cycle/DNA Damage Epigenetics Autophagy Apoptosis Metabolic Enzyme/Protease
  3. HDAC Autophagy Apoptosis Endogenous Metabolite
  4. Sodium butyrate

Sodium butyrate  (Synonyms: 丁酸鈉; Butanoic acid sodium; Butyric acid sodium)

目錄號(hào): HY-B0350A 純度: ≥98.0%
COA 產(chǎn)品使用指南

Sodium Butyrate (Butanoic acid sodium salt) 是一種短鏈脂肪酸，可以抑制組蛋白去乙酰化酶。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

Sodium butyrate Chemical Structure

Sodium butyrate Chemical Structure

CAS No. : 156-54-7

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500 mg ￥300
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1 g ￥350
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5 g ￥650
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Customer Review

Other Forms of Sodium butyrate:

    Sodium butyrate purchased from MCE. Usage Cited in: Neurobiol Dis. 2017 Dec 14;111:12-25.  [Abstract]

    Cdc42-Rac1 activation mediates the effect of SB on microglial process elongation. Representative images showing the activation effect of Cdc42 and Rac1 by Sodium butyrate (SB) (5 mM) at different time points (5, 10 min) in primary cultured microglia.

    • 生物活性

    • 實(shí)驗(yàn)參考方法

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    Sodium Butyrate (Butanoic acid sodium salt) is a histone deacetylase (HDAC) inhibitor, with anti-tumor effects in several cancers.

    IC50 & Target[2]

    HDAC

     

    Human Endogenous Metabolite

     

    Microbial Metabolite

     

    細(xì)胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    Erythrocyte CC50
    222 μM
    Compound: NaB
    Cytotoxicity against human erythrocytes assessed as cell viability after 3 days alamar blue assay
    Cytotoxicity against human erythrocytes assessed as cell viability after 3 days alamar blue assay
    		[PMID: 33109398]
    HeLa IC50
    0.8 mM
    Compound: Sodium butyrate
    Inhibition of HDAC in human Hela cells nuclear extracts by fluorimetric assay
    Inhibition of HDAC in human Hela cells nuclear extracts by fluorimetric assay
    		[PMID: 19520580]
    HUVEC IC50
    1 mM
    Compound: sodium butyrate
    Inhibition of LPS-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of LPS challenge by one stage clotting assay
    Inhibition of LPS-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of LPS challenge by one stage clotting assay
    		[PMID: 17675290]
    HUVEC IC50
    2 mM
    Compound: sodium butyrate
    Inhibition of TNF-alpha-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of TNFalpha challenge by one stage clotting assay
    Inhibition of TNF-alpha-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of TNFalpha challenge by one stage clotting assay
    		[PMID: 17675290]
    MDA-MB-231 GI50
    > 1000 μM
    Compound: BA, sodium butyrate
    Growth inhibition of human MDA-MB-231 cells after 5 days by MTT assay
    Growth inhibition of human MDA-MB-231 cells after 5 days by MTT assay
    		[PMID: 18543902]
    PC-3 GI50
    72.44 μM
    Compound: BA, sodium butyrate
    Growth inhibition of human PC3 cells after 5 days by MTT assay
    Growth inhibition of human PC3 cells after 5 days by MTT assay
    		[PMID: 18543902]
    體外研究
    (In Vitro)

    丁酸鈉可誘導(dǎo)鼻咽癌細(xì)胞的形態(tài)變化、抑制細(xì)胞增殖并削弱細(xì)胞活力。丁酸鈉 (1、5、10 mM) 對(duì)鼻咽癌細(xì)胞具有細(xì)胞毒性，在 5-8F 和 6-10B 細(xì)胞中均誘導(dǎo)劑量和時(shí)間依賴性的細(xì)胞活力下降。丁酸鈉通過激活線粒體凋亡軸誘導(dǎo)鼻咽癌細(xì)胞凋亡。此外，SOCE 抑制和 CRAC 通道破壞可減弱丁酸鈉誘導(dǎo)的細(xì)胞凋亡[1]。丁酸鈉顯著降低細(xì)胞活力，同時(shí)降低 p-mTOR 和 PCNA 蛋白水平。丁酸鈉以劑量依賴性方式誘導(dǎo)細(xì)胞周期停滯在 G0/G1 期，并減少 S 期細(xì)胞數(shù)量。此外，較高濃度的丁酸鈉（1、5、10 mM）可增加 p21、p27 和促凋亡 bak 基因的相對(duì)表達(dá)以及 p21Waf1/Cip1、p27Kip1、cyclinD3、CDK4 和 Cleave-caspase3 的蛋白水平，而 5 和 10 mM 丁酸鹽可降低 cyclinD1 和 CDK6 的水平[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    體內(nèi)研究
    (In Vivo)

    與未治療的動(dòng)物相比，HI 后立即給予丁酸鈉 (300 mg/kg，皮下) 可提供幾乎完全的神經(jīng)保護(hù)。給予丁酸鈉會(huì)導(dǎo)致同側(cè)小膠質(zhì)細(xì)胞數(shù)量增加至接受載體治療的動(dòng)物的 150%。丁酸鈉促進(jìn)新生兒缺氧缺血后小膠質(zhì)細(xì)胞從 M1 型極化為 M2 型表型[2]。丁酸鈉 (300 mg/kg，皮下) 與 AK-7 (20 mg/kg，腹腔注射) 組合可顯著緩解小鼠探索新物體時(shí)間的減少，改善小鼠齒狀回中 Ki67 陽(yáng)性細(xì)胞和 DCX 免疫反應(yīng)性神經(jīng)母細(xì)胞數(shù)量的減少。此外，丁酸鈉可逆轉(zhuǎn) SIRT2 相關(guān)的年齡表型[4]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    110.09

    Formula

    C4H7NaO2
    CAS 號(hào)
    性狀

    固體

    顏色

    White to off-white

    中文名稱

    丁酸鈉
    運(yùn)輸條件

    Room temperature in continental US; may vary elsewhere.
    儲(chǔ)存方式

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    溶解性數(shù)據(jù)
    細(xì)胞實(shí)驗(yàn)： 

    H2O 中的溶解度 : 100 mg/mL (908.36 mM; 超聲助溶)

    DMSO 中的溶解度 : 1 mg/mL (9.08 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開封的 DMSO)

    配制儲(chǔ)備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 9.0836 mL 45.4182 mL 90.8364 mL
    5 mM 1.8167 mL 9.0836 mL 18.1673 mL
    查看完整儲(chǔ)備液配制表

    * 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

    * 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

    • 摩爾計(jì)算器

    • 稀釋計(jì)算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動(dòng)物實(shí)驗(yàn)：

    以下溶解方案，請(qǐng)直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶。

    • 方案 一

      請(qǐng)依序添加每種溶劑： PBS

      Solubility: ≥ 100 mg/mL (908.36 mM); 澄清溶液

    動(dòng)物溶解方案計(jì)算器
    請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

    給藥劑量

    mg/kg

    動(dòng)物的平均體重

    g

    每只動(dòng)物的給藥體積

    μL

    動(dòng)物數(shù)量

    只
    由于實(shí)驗(yàn)過程有損耗，建議您多配一只動(dòng)物的量
    計(jì)算結(jié)果
    工作液所需濃度 : mg/mL
    該產(chǎn)品水溶性佳，請(qǐng)具體參考實(shí)測(cè) 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
    您所需的儲(chǔ)備液濃度超過該產(chǎn)品的實(shí)測(cè)溶解度，如有需要，請(qǐng)與 MCE 中國(guó)技術(shù)支持聯(lián)系。
    純度 & 產(chǎn)品資料

    純度: ≥98.0%

    參考文獻(xiàn)
    Cell Assay
    [1]

    Cells are seeded at a density of 2,000 cells/well in 96-well plates with 200 μL culture medium containing Sodium Butyrate at different concentrations. Then, the cells are consecutively cultured for 72 h. Every 24 h, 20 μL 5 mg/mL MTT solution is added into the corresponding well, and the cells are cultured for another 4 h. Then, the solution is replaced with 150 μL dimethylsulfoxide, followed by gentle agitation of the plates for 15 min at room temperature. Finally, the absorbance at 492 nm is measured to represent the cell viability.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [2]

    Seven-day-old rat pups are subjected to unilateral carotid artery ligation followed by 60 min of hypoxia (7.6% O2). Sodium Butyrate (300 mg/kg) is administered in a 5-day regime with the first injection given immediately after hypoxic exposure. The damage of the ipsilateral hemisphere is evaluated by hematoxylin-eosin staining 6 days after the insult. Samples are collected at 24 and 48 h and 6 days.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    參考文獻(xiàn)

    完整儲(chǔ)備液配制表

    * 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 9.0836 mL 45.4182 mL 90.8364 mL 227.0911 mL
    5 mM 1.8167 mL 9.0836 mL 18.1673 mL 45.4182 mL
    H2O 10 mM 0.9084 mL 4.5418 mL 9.0836 mL 22.7091 mL
    15 mM 0.6056 mL 3.0279 mL 6.0558 mL 15.1394 mL
    20 mM 0.4542 mL 2.2709 mL 4.5418 mL 11.3546 mL
    25 mM 0.3633 mL 1.8167 mL 3.6335 mL 9.0836 mL
    30 mM 0.3028 mL 1.5139 mL 3.0279 mL 7.5697 mL
    40 mM 0.2271 mL 1.1355 mL 2.2709 mL 5.6773 mL
    50 mM 0.1817 mL 0.9084 mL 1.8167 mL 4.5418 mL
    60 mM 0.1514 mL 0.7570 mL 1.5139 mL 3.7849 mL
    80 mM 0.1135 mL 0.5677 mL 1.1355 mL 2.8386 mL
    100 mM 0.0908 mL 0.4542 mL 0.9084 mL 2.2709 mL

    * 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    產(chǎn)品名稱：
    Sodium butyrate
    目錄號(hào)：
    HY-B0350A
    需求量：