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  2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. Toremifene

Toremifene  (Synonyms: Z-Toremifene; NK 622 free base; FC-1157a free base)

目錄號(hào): HY-B0005A 純度: 99.86%
COA 產(chǎn)品使用指南 技術(shù)支持

Toremifene (Z-Toremifene) 是第二代選擇性雌激素受體調(diào)節(jié)劑，對(duì)雌激素受體的 IC50 為 1μM。Toremifene 還可以有效抑制傳染性 EBOV Zaire 和 Marburg (MARV)，IC50 分別為 0.07 μM 和 2.6 μM。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

Toremifene Chemical Structure

Toremifene Chemical Structure

CAS No. : 89778-26-7

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥293
In-stock
5 mg ￥267
In-stock
10 mg ￥400
In-stock
25 mg ￥720
In-stock
50 mg   詢價(jià)  
100 mg   詢價(jià)  

* Please select Quantity before adding items.

Other Forms of Toremifene:

查看 Estrogen Receptor/ERR 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Toremifene (Z-Toremifene) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.07 μM and 2.6 μM, respectively[1][2].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 EC50
0.09 μM
Compound: toremifene
Inhibition of pseudotyped HIV/EBOV GP infected in human A549 cells assessed as reduction in virus entry measured after 48 hrs by luciferase reporter gene assay
Inhibition of pseudotyped HIV/EBOV GP infected in human A549 cells assessed as reduction in virus entry measured after 48 hrs by luciferase reporter gene assay
[PMID: 32490678]
HeLa EC50
0.67 μM
Compound: toremifene
Antiviral activity against Ebola virus 1976 Mayinga infected in human HeLa cells pretreated for 1 hr followed by virus infection measured after 24 hrs by Hoechst staining-based immunofluorescence assay
Antiviral activity against Ebola virus 1976 Mayinga infected in human HeLa cells pretreated for 1 hr followed by virus infection measured after 24 hrs by Hoechst staining-based immunofluorescence assay
[PMID: 32490678]
HeLa EC50
3.25 μM
Compound: toremifene
Antiviral activity against Marburg virus Lake Victoria, 2005 Angola infected in human HeLa cells pretreated for 1 hr followed by virus infection measured after 24 hrs by Hoechst staining-based immunofluorescence assay
Antiviral activity against Marburg virus Lake Victoria, 2005 Angola infected in human HeLa cells pretreated for 1 hr followed by virus infection measured after 24 hrs by Hoechst staining-based immunofluorescence assay
[PMID: 32490678]
Huh-7 CC50
9.31 μM
Compound: 9
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability by cellular ATP method
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability by cellular ATP method
[PMID: 35872393]
MCF-10A IC50
> 100 μM
Compound: Toremifene
Cytotoxicity against human MCF10A cells by MTT assay
Cytotoxicity against human MCF10A cells by MTT assay
[PMID: 31546197]
MCF7 IC50
7 μM
Compound: Toremifene
Antiproliferative activity against human MCF7 cells by MTT assay
Antiproliferative activity against human MCF7 cells by MTT assay
[PMID: 31546197]
MDA-MB-231 IC50
13 μM
Compound: Toremifene
Antiproliferative activity against human MDA-MB-231 cells by MTT assay
Antiproliferative activity against human MDA-MB-231 cells by MTT assay
[PMID: 31546197]
Vero CC50
10.11 μM
Compound: Toremiphene
Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr
Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr
10.1101/2020.03.20.999730
Vero IC50
3.58 μM
Compound: Toremiphene
Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr
Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr
10.1101/2020.03.20.999730
體外研究
(In Vitro)

Toremifene is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis and other adverse effects resulting from ADT with prostate cancer[1].
The growth of Ac-1 cells was inhibited by tamoxifen, toremifene and atamestane in vitro with IC50values of 1.8±1.3μM, 1±0.3μM and 60.4±17.2μM, respectively. The combination of toremifene plusatamestane was found to be better than toremifene or atamestane alone in vitro[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

The effect of this combination was then studied in vivo using Ac-1 xenografts grown in ovariectomized female SCID mice. The mice were injected with toremifene (1000μg/day), atamestane (1000μg/day), tamoxifen (100μg/day), or the combination of toremifene plus atamestane. In this study, our results indicate that the combination of toremifene plus atamestane was as effective as toremifene or tamoxifen alone but may not provide any additional benefit over toremifene alone or tamoxifen alone[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

405.96

Formula

C26H28ClNO
CAS 號(hào)
性狀

固體

顏色

White to light yellow

中文名稱

托瑞米芬；濤瑞米芬
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 62.5 mg/mL (153.96 mM; 超聲助溶 (<60°C); 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.4633 mL 12.3165 mL 24.6330 mL
5 mM 0.4927 mL 2.4633 mL 4.9266 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.86%

參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4633 mL 12.3165 mL 24.6330 mL 61.5824 mL
5 mM 0.4927 mL 2.4633 mL 4.9266 mL 12.3165 mL
10 mM 0.2463 mL 1.2316 mL 2.4633 mL 6.1582 mL
15 mM 0.1642 mL 0.8211 mL 1.6422 mL 4.1055 mL
20 mM 0.1232 mL 0.6158 mL 1.2316 mL 3.0791 mL
25 mM 0.0985 mL 0.4927 mL 0.9853 mL 2.4633 mL
30 mM 0.0821 mL 0.4105 mL 0.8211 mL 2.0527 mL
40 mM 0.0616 mL 0.3079 mL 0.6158 mL 1.5396 mL
50 mM 0.0493 mL 0.2463 mL 0.4927 mL 1.2316 mL
60 mM 0.0411 mL 0.2053 mL 0.4105 mL 1.0264 mL
80 mM 0.0308 mL 0.1540 mL 0.3079 mL 0.7698 mL
100 mM 0.0246 mL 0.1232 mL 0.2463 mL 0.6158 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Toremifene
目錄號(hào)：
HY-B0005A
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