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  2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. Calyculin A

Calyculin A  (Synonyms: 花萼海綿體誘癌素A; (-)-Calyculin A)

目錄號(hào): HY-18983
COA 產(chǎn)品使用指南

Calyculin A ((-)-Calyculin A) 是有效，可滲透細(xì)胞的蛋白磷酸酶 1 (PP1) 和蛋白磷酸酶 2A (PP2A) 抑制劑，其 IC50 值分別為 2 nM 和 0.5-1 nM。

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Calyculin A Chemical Structure

Calyculin A Chemical Structure

CAS No. : 101932-71-2

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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Calyculin A ((-)-Calyculin A) is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC50s of 2 nM and 0.5-1 nM, respectively[1].

IC50 & Target

IC50: 2 nM (PP1); 0.5-1 nM (PP2A)[1]
體外研究
(In Vitro)

CalycuLin A (1-10 nM；24 小時(shí)) 在 MG63 細(xì)胞中以劑量依賴性方式誘導(dǎo)細(xì)胞毒性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[2]

Cell Line: Human osteosarcoma MG63 cells
Concentration: 0, 1, 2, 5, 10 nM
Incubation Time: 24 hours
Result: Treatment with 0.1 nM for 24 h had a minimal effect on MG63 cell survival. Cell rounding and shrinking were obvious in the cultures treated for 24 h with 5 nM. The level of the cell viability treated with 10 nM was 27% that of the control cultures.
分子量

1009.17

Formula

C50H81N4O15P
CAS 號(hào)
性狀

液體

顏色

Colorless to light yellow

中文名稱

花萼海綿體誘癌素A
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

Solution, -20°C, 2 years
純度 & 產(chǎn)品資料

純度: 99.67%

參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Calyculin A
目錄號(hào)：
HY-18983
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