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  2. Cell Cycle/DNA Damage
  3. DNA Alkylator/Crosslinker
  4. Satraplatin

Satraplatin  (Synonyms: 沙鉑; BMS182751; BMY45594; JM216)

目錄號(hào): HY-17576 純度: 99.79%
COA 產(chǎn)品使用指南

Satraplatin 是一種烷化劑 (alkylator)，具有抗腫瘤效果。

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Satraplatin Chemical Structure

Satraplatin Chemical Structure

CAS No. : 129580-63-8

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥1150
In-stock
5 mg ￥2800
In-stock
10 mg ￥4000
In-stock
25 mg 現(xiàn)貨 詢價(jià)
50 mg 現(xiàn)貨 詢價(jià)
100 mg 現(xiàn)貨 詢價(jià)
200 mg   詢價(jià)  
500 mg   詢價(jià)  

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MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻(xiàn)

  • 生物活性

  • 實(shí)驗(yàn)參考方法

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Satraplatin is an alkylating agent, with potent antitumor effect.

體外研究
(In Vitro)

Satraplatin needs to avoid light in the solution, and it is unstable in the alkaline state but stable in the acidic state.
Satraplatin has potent antitumor activity. Satraplatin combined with dichloroacetate (DCA) inhibits UMC-11 cells with an IC50 of 1.36 ± 0.11 μM[1]. Satraplatin also suppresses CDDP-resistant (KB-R) cells (IC50, 7.04 μM), and causes G2/M arrest in KB-R cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

500.28

Formula

C10H22Cl2N2O4Pt
CAS 號(hào)
性狀

固體

顏色

Off-white to yellow

中文名稱

賽特鉑；沙鉑
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMF 中的溶解度 : 10 mg/mL (19.99 mM; 超聲助溶; 酸性條件溶解 (HCL 調(diào)節(jié)，pH≈1); DMSO can inactivate Satraplatin's activity)

H2O 中的溶解度 : < 0.1 mg/mL (insoluble; DMSO can inactivate Satraplatin's activity)

Ethanol 中的溶解度 : < 1 mg/mL (insoluble; DMSO can inactivate Satraplatin's activity)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 1.9989 mL 9.9944 mL 19.9888 mL
5 mM 0.3998 mL 1.9989 mL 3.9978 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用， -20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.79%

參考文獻(xiàn)
Cell Assay
[1]

Cells are harvested, counted and distributed to microtiter plates in 100 μL medium at a density of 1×104 cells/well. Appropriate dilutions of test compounds (Satraplatin, etc.) are added to a total volume of 200 μL/well and plates incubated under tissue culture conditions for four days. Stock solutions of the compounds are prepared in either 70% ethanol or DMSO and diluted more than 100-fold for the assays. Solvent controls are included in all tests. Dose response curves are obtained by assessing cell proliferation at twofold drug dilutions in triplicate and used for calculation of IC50 values. Cell growth is quantified using a modified tetrazolium dye assay (MTT) and by measurement of the reduced formazane dye at 450 nm wavelength (medium control set to 100% proliferation)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用， -20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 1.9989 mL 9.9944 mL 19.9888 mL 49.9720 mL
5 mM 0.3998 mL 1.9989 mL 3.9978 mL 9.9944 mL
10 mM 0.1999 mL 0.9994 mL 1.9989 mL 4.9972 mL
15 mM 0.1333 mL 0.6663 mL 1.3326 mL 3.3315 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Satraplatin
目錄號(hào)：
HY-17576
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