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  2. Metabolic Enzyme/Protease PI3K/Akt/mTOR
  3. Glycosidase PI3K
  4. 1-Deoxynojirimycin

1-Deoxynojirimycin  (Synonyms: 1-脫氧野尻霉素; Duvoglustat)

目錄號: HY-14860 純度: ≥98.0%
COA 產(chǎn)品使用指南

1-Deoxynojirimycin (Duvoglustat) 是一種口服有效的 α-葡萄糖苷酶 (α-glucosidase) 抑制劑。1-Deoxynojirimycin 抑制餐后血糖，預(yù)防糖尿病。1-Deoxynojirimycin 具有降血糖、減肥和抗病毒的作用。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務(wù)

1-Deoxynojirimycin Chemical Structure

1-Deoxynojirimycin Chemical Structure

CAS No. : 19130-96-2

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2.  同一機構(gòu)（單位）同一產(chǎn)品試用裝僅限申領(lǐng)一次，同一機構(gòu)（單位）一年內(nèi)

     可免費申領(lǐng)三個不同產(chǎn)品的試用裝。

3.  試用裝只面向終端客戶。

規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥348
In-stock
2 mg ￥491
In-stock
5 mg ￥824
In-stock
10 mg ￥1234
In-stock
25 mg ￥2475
In-stock
50 mg ￥3500
In-stock
100 mg ￥4900
In-stock
200 mg   詢價  
500 mg   詢價  

* Please select Quantity before adding items.

Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

1-Deoxynojirimycin (Duvoglustat) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features[1][2].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 10 μM
Compound: 1
Cytotoxicity against human A549 cells measured after 48 hrs by MTT assay
Cytotoxicity against human A549 cells measured after 48 hrs by MTT assay
[PMID: 33979163]
A549 IC50
> 1000 μM
Compound: DNJ
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
[PMID: 21036045]
BGC-823 IC50
> 10 μM
Compound: 1
Cytotoxicity against human BGC-823 cells measured after 48 hrs by MTT assay
Cytotoxicity against human BGC-823 cells measured after 48 hrs by MTT assay
[PMID: 33979163]
Caco-2 IC50
0.06 μM
Compound: 1, DNJ
Inhibition of maltase in human Caco-2 cell model system after 2 hrs
Inhibition of maltase in human Caco-2 cell model system after 2 hrs
[PMID: 18595718]
HCC1937 IC50
> 10 μM
Compound: 1
Cytotoxicity against human HCC1937 cells measured after 48 hrs by MTT assay
Cytotoxicity against human HCC1937 cells measured after 48 hrs by MTT assay
[PMID: 33979163]
HCT-116 IC50
> 10 μM
Compound: 1
Cytotoxicity against human HCT-116 cells measured after 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells measured after 48 hrs by MTT assay
[PMID: 33979163]
HEK293 IC50
> 100 μM
Compound: dNM, 1-deoxynojirimycin
Antagonist activity at human recombinant LXRalpha expressed in HEK293 cells by luciferase reporter gene assay
Antagonist activity at human recombinant LXRalpha expressed in HEK293 cells by luciferase reporter gene assay
[PMID: 18343126]
HEK293 IC50
> 100 μM
Compound: dNM, 1-deoxynojirimycin
Antagonist activity at human recombinant LXRbeta expressed in HEK293 cells by luciferase reporter gene assay
Antagonist activity at human recombinant LXRbeta expressed in HEK293 cells by luciferase reporter gene assay
[PMID: 18343126]
HepG2 IC50
> 10 μM
Compound: 1
Cytotoxicity against human HepG2 cells measured after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells measured after 48 hrs by MTT assay
[PMID: 33979163]
HUVEC IC50
2 μM
Compound: 2a
Growth inhibition of HUVEC cells by MTT assay
Growth inhibition of HUVEC cells by MTT assay
[PMID: 18166456]
MCF7 IC50
> 10 μM
Compound: 1
Cytotoxicity against human MCF7 cells measured after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells measured after 48 hrs by MTT assay
[PMID: 33979163]
MS-1 IC50
2 μM
Compound: 2a
Growth inhibition of mouse MS1 cells by MTT assay
Growth inhibition of mouse MS1 cells by MTT assay
[PMID: 18166456]
體內(nèi)研究
(In Vivo)

1-Deoxynojirimycin (Duvoglustat) (20 -80 mg/kg；iv；每日一次，持續(xù) 4 周) 顯示抗肥胖作用[3]。
1-Deoxynojirimycin 通過激活顯著改善胰島素敏感性 db/db 小鼠骨骼肌胰島素信號通路 PI3K/AKT[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: db/db mice[3]
Dosage: 20, 40, 80 mg/kg
Administration: Intravenously; daily for four weeks
Result: Significantly reduced body weight, blood glucose and serum insulin levels; Improved glucose tolerance and insulin tolerance.
Clinical Trial
分子量

163.17

Formula

C6H13NO4
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

1-脫氧野尻霉素；脫氧野尻霉素
結(jié)構(gòu)分類
初始來源
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細(xì)胞實驗： 

H2O 中的溶解度 : ≥ 34 mg/mL (208.37 mM)

* "≥" means soluble, but saturation unknown.

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 6.1286 mL 30.6429 mL 61.2858 mL
5 mM 1.2257 mL 6.1286 mL 12.2572 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用， -20°C儲存時，請在1年內(nèi)使用。

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物實驗：

以下溶解方案，請直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶。

  • 方案 一

    請依序添加每種溶劑： PBS

    Solubility: 100 mg/mL (612.86 mM); 澄清溶液; 超聲助溶

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
該產(chǎn)品水溶性佳，請具體參考實測 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
您所需的儲備液濃度超過該產(chǎn)品的實測溶解度，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。
純度 & 產(chǎn)品資料

純度: 99.94%

參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用， -20°C儲存時，請在1年內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 6.1286 mL 30.6429 mL 61.2858 mL 153.2144 mL
5 mM 1.2257 mL 6.1286 mL 12.2572 mL 30.6429 mL
10 mM 0.6129 mL 3.0643 mL 6.1286 mL 15.3214 mL
15 mM 0.4086 mL 2.0429 mL 4.0857 mL 10.2143 mL
20 mM 0.3064 mL 1.5321 mL 3.0643 mL 7.6607 mL
25 mM 0.2451 mL 1.2257 mL 2.4514 mL 6.1286 mL
30 mM 0.2043 mL 1.0214 mL 2.0429 mL 5.1071 mL
40 mM 0.1532 mL 0.7661 mL 1.5321 mL 3.8304 mL
50 mM 0.1226 mL 0.6129 mL 1.2257 mL 3.0643 mL
60 mM 0.1021 mL 0.5107 mL 1.0214 mL 2.5536 mL
80 mM 0.0766 mL 0.3830 mL 0.7661 mL 1.9152 mL
100 mM 0.0613 mL 0.3064 mL 0.6129 mL 1.5321 mL

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
1-Deoxynojirimycin
目錄號：
HY-14860
需求量：