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  2. Anti-infection
  3. HBV
  4. Entecavir

Entecavir  (Synonyms: 恩替卡韋; BMS200475; SQ34676)

目錄號: HY-13623 純度: 99.98%
COA 產(chǎn)品使用指南 技術支持

Entecavir（SQ 34676; BMS 200475）是有選擇且有效地HBV抑制劑，在HepG2細胞中的EC50值為3.75 nM。

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Entecavir Chemical Structure

Entecavir Chemical Structure

CAS No. : 142217-69-4

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥671
In-stock
1 mg ￥220
In-stock
5 mg ￥550
In-stock
10 mg ￥990
In-stock
25 mg ￥1480
In-stock
50 mg ￥2090
In-stock
100 mg ￥3700
In-stock
200 mg   詢價  
500 mg   詢價  

* Please select Quantity before adding items.

Customer Review

Other Forms of Entecavir:

  • 生物活性

  • 實驗參考方法

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Entecavir (SQ 34676; BMS 200475) is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cell.

IC50 & Target

EC50: 3.75 nM (anti-HBV, HepG2 cell)[2]
體外研究
(In Vitro)

BMS-200475 has a EC50 of 3.75 nM against HBV. It is incorporated into the protein primer of HBV and subsequently inhibits the priming step of the reverse transcriptase. The antiviral activity of BMS-200475 is significantly less against the other RNA and DNA viruses[1]. Entecavir is more readily phosphorylated to its active metabolites than other deoxyguanosine analogs (penciclovir, ganciclovir, lobucavir, and aciclovir) or lamivudine. The intracellular half-life of entecavir is 15 h[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Daily oral treatment with BMS-200475 at doses ranging from 0.02 to 0.5 mg/kg of body weight for 1 to 3 months effectively reduces the level of woodchuck hepatitis virus (WHV) viremia in chronically infected woodchucks[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

277.28

Formula

C12H15N5O3
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

恩替卡韋
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : ≥ 44 mg/mL (158.68 mM; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制儲備液
濃度 溶劑體積 質量 1 mg 5 mg 10 mg
1 mM 3.6065 mL 18.0323 mL 36.0646 mL
5 mM 0.7213 mL 3.6065 mL 7.2129 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.98%

參考文獻
Cell Assay
[1]

BMS 200475 is prepared in phosphate-buffered saline (PBS) and diluted with appropriate medium containing 2% fetal bovine serum. HepG2 2.2.15 cells are plated at a density of 5×105 cells per well on 12-well Biocoat collagen-coated plates and are maintained in a confluent state for 2 to 3 days before being overlaid with 1 mL of medium spiked with BMS 200475. Quantification of HBV was performed on day 10[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6065 mL 18.0323 mL 36.0646 mL 90.1616 mL
5 mM 0.7213 mL 3.6065 mL 7.2129 mL 18.0323 mL
10 mM 0.3606 mL 1.8032 mL 3.6065 mL 9.0162 mL
15 mM 0.2404 mL 1.2022 mL 2.4043 mL 6.0108 mL
20 mM 0.1803 mL 0.9016 mL 1.8032 mL 4.5081 mL
25 mM 0.1443 mL 0.7213 mL 1.4426 mL 3.6065 mL
30 mM 0.1202 mL 0.6011 mL 1.2022 mL 3.0054 mL
40 mM 0.0902 mL 0.4508 mL 0.9016 mL 2.2540 mL
50 mM 0.0721 mL 0.3606 mL 0.7213 mL 1.8032 mL
60 mM 0.0601 mL 0.3005 mL 0.6011 mL 1.5027 mL
80 mM 0.0451 mL 0.2254 mL 0.4508 mL 1.1270 mL
100 mM 0.0361 mL 0.1803 mL 0.3606 mL 0.9016 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Entecavir
目錄號：
HY-13623
需求量：