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  2. Apoptosis
  3. Apoptosis
  4. D-α-Tocopherol Succinate

D-α-Tocopherol Succinate  (Synonyms: D-α-生育酚琥珀酸酯; Vitamin E succinate)

目錄號(hào): HY-131553 純度: ≥98.0%
COA 產(chǎn)品使用指南

D-α-Tocopherol Succinate (Vitamin E succinate) 是一種抗氧化生育酚，是維生素 E 的一種鹽形式。D-α-Tocopherol Succinat 抑制 Cisplatin (HY-17394) 引起的毒性。D-α-Tocopherol Succinate 可用于癌癥的研究。

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D-α-Tocopherol Succinate Chemical Structure

D-α-Tocopherol Succinate Chemical Structure

CAS No. : 4345-03-3

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規(guī)格 價(jià)格 是否有貨 數(shù)量
100 mg ￥400
In-stock
250 mg ￥600
In-stock
500 mg ￥760
In-stock
1 g   詢價(jià)  
5 g   詢價(jià)  

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Customer Review

Other Forms of D-α-Tocopherol Succinate:

MCE 顧客使用本產(chǎn)品發(fā)表的 2 篇科研文獻(xiàn)

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer[1][2].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
4T1 IC50
10 μM
Compound: 1, VES
Inhibition of mouse 4T1 cells adhesion to gelatinous matrix protein-coated surface after 60 mins by ELISA
Inhibition of mouse 4T1 cells adhesion to gelatinous matrix protein-coated surface after 60 mins by ELISA
[PMID: 19708661]
HCT-116 IC50
52.3 μM
Compound: alpha-TOS
Cytotoxicity against Homo sapiens (human) HCT116 cells after 48 hr by SRB assay
Cytotoxicity against Homo sapiens (human) HCT116 cells after 48 hr by SRB assay
10.1007/s00044-011-9801-3
HepG2 IC50
245 μM
Compound: alpha-TOS
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 27344490]
HepG2 IC50
55 μM
Compound: alpha-TOS
Cytotoxicity against Homo sapiens (human) HepG2 cells after 48 hr by SRB assay
Cytotoxicity against Homo sapiens (human) HepG2 cells after 48 hr by SRB assay
10.1007/s00044-011-9801-3
MCF7 IC50
57 μM
Compound: alpha-TOS
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 27344490]
MT4 IC50
66 μM
Compound: alpha-TOS
Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 27344490]
RPMI-8226 IC50
63 μM
Compound: alpha-TOS
Cytotoxicity against human RPMI8226 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human RPMI8226 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 27344490]
U-937 IC50
113 μM
Compound: alpha-TOS
Cytotoxicity against human U937 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human U937 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 27344490]
體外研究
(In Vitro)

D-α-Tocopherol Succinate (1-20 μM；24 小時(shí)) 對(duì) HEI-OC1 細(xì)胞顯示出細(xì)胞毒性[1]。
D-α-Tocopherol Succinate (10 μM；48 小時(shí)) 保護(hù) HEI-OC1 細(xì)胞免受順鉑誘導(dǎo)的耳毒性并抑制 caspase-3 活性[1]。
D-α-Tocopherol Succinate (0-50 μM；18 小時(shí)) 顯示出對(duì) TC 的細(xì)胞毒性-1 個(gè)腫瘤細(xì)胞[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: HEI-OC1 cell line
Concentration: 1-20 μM
Incubation Time: 24 hours
Result: Significantly induced cytotoxicity at a concentration of 20 μM and showed a higher cytotoxicity potency compared with 10 μM.

Cell Viability Assay[1]

Cell Line: HEI-OC1 cell line
Concentration: 10 μM
Incubation Time: 48 hours
Result: Increased cisplatin-induced cell population. Inhibited cisplatin-induced necrotic, ROS production and late apoptosis. Decreased cleaved PARP and inhibited the expression of caspase-3 which related to cisplatin-induced apoptosis.

Cell Cytotoxicity Assay[2]

Cell Line: TC-1 tumor cells
Concentration: 0, 25 and 50 μM
Incubation Time: 18 hours
Result: Dose-dependently showed cytotoxic and induced a higher percentage of necrotic TC-1 cells as opposed to apoptotic cells.
體內(nèi)研究
(In Vivo)

D-α-Tocopherol Succinate (1-2 mg/kg；從 TC-1 腫瘤細(xì)胞注射開(kāi)始每隔 2 天腹腔注射 3 次，持續(xù) 10 天至 14 天) 對(duì) TC-1 腫瘤小鼠顯示出抗腫瘤作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six- to eight-week-old female C57BL/6 mice with TC-1 tumor cells[2]
Dosage: 1 and 2 mg/kg
Administration: Intraperitoneal injection; 1 and 2 mg/kg three times at 2 day intervals; from TC-1 tumor cells injection for 10 days to 14 days
Result: Dreased the tumor volume, especially with a dose of 2 mg/kg.
分子量

530.78

Formula

C33H54O5
CAS 號(hào)
性狀

固體

顏色

White to off-white

中文名稱

D-α-生育酚琥珀酸酯；維生素E琥珀酸酯
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 250 mg/mL (471.00 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 1.8840 mL 9.4201 mL 18.8402 mL
5 mM 0.3768 mL 1.8840 mL 3.7680 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: ≥98.0%

參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8840 mL 9.4201 mL 18.8402 mL 47.1005 mL
5 mM 0.3768 mL 1.8840 mL 3.7680 mL 9.4201 mL
10 mM 0.1884 mL 0.9420 mL 1.8840 mL 4.7100 mL
15 mM 0.1256 mL 0.6280 mL 1.2560 mL 3.1400 mL
20 mM 0.0942 mL 0.4710 mL 0.9420 mL 2.3550 mL
25 mM 0.0754 mL 0.3768 mL 0.7536 mL 1.8840 mL
30 mM 0.0628 mL 0.3140 mL 0.6280 mL 1.5700 mL
40 mM 0.0471 mL 0.2355 mL 0.4710 mL 1.1775 mL
50 mM 0.0377 mL 0.1884 mL 0.3768 mL 0.9420 mL
60 mM 0.0314 mL 0.1570 mL 0.3140 mL 0.7850 mL
80 mM 0.0236 mL 0.1178 mL 0.2355 mL 0.5888 mL
100 mM 0.0188 mL 0.0942 mL 0.1884 mL 0.4710 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
D-α-Tocopherol Succinate
目錄號(hào)：
HY-131553
需求量：