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  2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. m-PEG6-Amine

m-PEG6-Amine 是一種 PROTAC 連接橋，屬于 PEG 類。m-PEG6-Amine 可用于合成一系列 PROTAC 分子。m-PEG6-Amine 是一種可降解 (cleavable) 的 ADC 連接橋，用于抗體活性分子結(jié)合物 (ADCs) 的合成。

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m-PEG6-Amine Chemical Structure

m-PEG6-Amine Chemical Structure

CAS No. : 184357-46-8

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規(guī)格 價格 是否有貨 數(shù)量
100 mg ￥118
In-stock
250 mg ￥251
In-stock
1 g ￥1000
In-stock
5 g ￥4163
詢價
10 g 現(xiàn)貨 詢價
50 g   詢價  

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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

m-PEG6-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG6-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1][2]

Cleavable Linker

 

PEGs

 

體外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

295.37

Formula

C13H29NO6
CAS 號
性狀

液體（密度：1.036±0.06 g/cm3）

顏色

Colorless to light yellow

運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

純度 & 產(chǎn)品資料

純度: ≥97.0%

參考文獻

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  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
m-PEG6-Amine
目錄號：
HY-130408
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