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  2. Epigenetics Anti-infection
  3. Protein Arginine Deiminase Antibiotic
  4. Streptonigrin

Streptonigrin  (Synonyms: Bruneomycin)

目錄號: HY-124586 純度: 99.20%
COA 產(chǎn)品使用指南

Streptonigrin (Bruneomycin) 是由鏈霉菌 (Streptomyces flocculus) 產(chǎn)生的一種天然產(chǎn)物，具有抗腫瘤和抗菌活性。Streptonigrin 可作為 pan-PAD 抑制劑，抑制 PAD1，PAD2，PAD3 和 PAD4 的 IC50 分別為 48.3±34.2 μM，26.1±0.3 μM，0.43±0.03 μM 和 2.5±0.4 μM。

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Streptonigrin Chemical Structure

Streptonigrin Chemical Structure

CAS No. : 3930-19-6

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規(guī)格 價格 是否有貨 數(shù)量
500 μg ￥1720
In-stock
1 mg ￥2800
In-stock
5 mg   詢價  
10 mg   詢價  

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Customer Review

Other Forms of Streptonigrin:

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻(xiàn)

WB

    Streptonigrin purchased from MCE. Usage Cited in: Sci Signal. 2023 Mar 14;16(776):eabq3362.  [Abstract]

    Streptonigrin (SUMOylation agonist; 2, 4, 8 μM; 48 h) markedly increases the amount of IL-33 protein SUMOylation in Huh7 cells transfected with wild-type IL-33.

    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    Streptonigrin (Bruneomycin), a natural product produced by Streptomyces flocculus, possesses both anti-tumor and anti-bacterial activity. Streptonigrin acts as a pan-PAD inhibitor with IC50s of 48.3±34.2 μM, 26.1±0.3 μM, 0.43±0.03 μM, and 2.5±0.4 μM for PAD1, PAD2, PAD3, and PAD4, respectively[1].

    IC50 & Target

    Anti-bacterial[1]
    IC50: 48.3±34.2 μM (PAD1), 26.1±0.3 μM, (PAD2), 0.43±0.03 μM (PAD3), 2.5±0.4 μM (PAD4)[1]
    細(xì)胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    A549 IC50
    0.33 μg/mL
    Compound: 1
    Cytotoxicity against Homo sapiens (human) A549 cells after 72 hr by MTT assay
    Cytotoxicity against Homo sapiens (human) A549 cells after 72 hr by MTT assay
    		10.1007/s00044-004-0032-8
    A549 IC50
    0.33 μg/mL
    Compound: Streptonigrin
    In vitro cytotoxic activity against A 549 (non-small cell lung) using SRB (sulforhodamine B) assay
    In vitro cytotoxic activity against A 549 (non-small cell lung) using SRB (sulforhodamine B) assay
    		[PMID: 10328288]
    CAKI-1 IC50
    0.4 nM
    Compound: 1
    Cytotoxicity against CD30 deficient and CD70 expressing human Caki1 cells after 96 hrs by resazurin conversion assay
    Cytotoxicity against CD30 deficient and CD70 expressing human Caki1 cells after 96 hrs by resazurin conversion assay
    		[PMID: 19386499]
    HCT-15 IC50
    0.02 μg/mL
    Compound: 1
    Cytotoxicity against Homo sapiens (human) HCT15 cells after 72 hr by MTT assay
    Cytotoxicity against Homo sapiens (human) HCT15 cells after 72 hr by MTT assay
    		10.1007/s00044-004-0032-8
    HCT-15 IC50
    0.02 μg/mL
    Compound: Streptonigrin
    In vitro cytotoxic activity against HCT-15 (colon) using SRB (sulforhodamine B) assay
    In vitro cytotoxic activity against HCT-15 (colon) using SRB (sulforhodamine B) assay
    		[PMID: 10328288]
    KARPAS-299 IC50
    0.4 nM
    Compound: 1
    Cytotoxicity against CD30 expressing and CD70 deficient human KARPAS299 cells after 96 hrs by resazurin conversion assay
    Cytotoxicity against CD30 expressing and CD70 deficient human KARPAS299 cells after 96 hrs by resazurin conversion assay
    		[PMID: 19386499]
    SK-MEL-2 IC50
    0.02 μg/mL
    Compound: 1
    Cytotoxicity against Homo sapiens (human) SK-MEL-2 cells after 72 hr by MTT assay
    Cytotoxicity against Homo sapiens (human) SK-MEL-2 cells after 72 hr by MTT assay
    		10.1007/s00044-004-0032-8
    SK-MEL-2 IC50
    0.02 μg/mL
    Compound: Streptonigrin
    In vitro cytotoxic activity against SK-MEL-2 (melanoma) using SRB (sulforhodamine B) assay
    In vitro cytotoxic activity against SK-MEL-2 (melanoma) using SRB (sulforhodamine B) assay
    		[PMID: 10328288]
    SK-OV-3 IC50
    0.28 μg/mL
    Compound: 1
    Cytotoxicity against Homo sapiens (human) SKOV3 cells after 72 hr by MTT assay
    Cytotoxicity against Homo sapiens (human) SKOV3 cells after 72 hr by MTT assay
    		10.1007/s00044-004-0032-8
    SK-OV-3 IC50
    0.28 μg/mL
    Compound: Streptonigrin
    In vitro cytotoxic activity against SK-OV-3 (ovarian) using SRB (sulforhodamine B) assay
    In vitro cytotoxic activity against SK-OV-3 (ovarian) using SRB (sulforhodamine B) assay
    		[PMID: 10328288]
    T-cell IC50
    < 20 μM
    Compound: 1, NSC-45383
    Inhibition of JAK-mediated IL6-induced Stat1 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry
    Inhibition of JAK-mediated IL6-induced Stat1 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry
    		[PMID: 18157122]
    T-cell IC50
    < 20 μM
    Compound: 1, NSC-45383
    Inhibition of JAK-mediated IL10-induced Stat3 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry
    Inhibition of JAK-mediated IL10-induced Stat3 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry
    		[PMID: 18157122]
    T-cell IC50
    < 20 μM
    Compound: 1, NSC-45383
    Inhibition of JAK-mediated interferon-gamma-induced Stat1 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry
    Inhibition of JAK-mediated interferon-gamma-induced Stat1 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry
    		[PMID: 18157122]
    T-cell IC50
    < 20 μM
    Compound: 1, NSC-45383
    Inhibition of JAK-mediated IL6-induced Stat3 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry
    Inhibition of JAK-mediated IL6-induced Stat3 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry
    		[PMID: 18157122]
    T-cell IC50
    < 20 μM
    Compound: 1, NSC-45383
    Inhibition of JAK-mediated IL15-induced Stat5 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry
    Inhibition of JAK-mediated IL15-induced Stat5 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry
    		[PMID: 18157122]
    T-cell IC50
    < 20 μM
    Compound: 1, NSC-45383
    Inhibition of JAK-mediated IL7-induced Stat5 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry
    Inhibition of JAK-mediated IL7-induced Stat5 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry
    		[PMID: 18157122]
    T-cell IC50
    < 20 μM
    Compound: 1, NSC-45383
    Inhibition of JAK-mediated IL4-induced Stat6 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry
    Inhibition of JAK-mediated IL4-induced Stat6 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry
    		[PMID: 18157122]
    T-cell IC50
    < 20 μM
    Compound: 1, NSC-45383
    Inhibition of JAK-mediated IL4-induced Stat5 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry
    Inhibition of JAK-mediated IL4-induced Stat5 phosphorylation in BALB/c mouse CD4+ T cells by Phospho-Flow cytometry
    		[PMID: 18157122]
    T-cell IC50
    < 20 μM
    Compound: 1, NSC-45383
    Inhibition of JAK-mediated IL6-induced Stat1 phosphorylation in BALB/c mouse CD8+ T cells by Phospho-Flow cytometry
    Inhibition of JAK-mediated IL6-induced Stat1 phosphorylation in BALB/c mouse CD8+ T cells by Phospho-Flow cytometry
    		[PMID: 18157122]
    T-cell IC50
    < 20 μM
    Compound: 1, NSC-45383
    Inhibition of JAK-mediated IL10-induced Stat3 phosphorylation in BALB/c mouse CD8+ T cells by Phospho-Flow cytometry
    Inhibition of JAK-mediated IL10-induced Stat3 phosphorylation in BALB/c mouse CD8+ T cells by Phospho-Flow cytometry
    		[PMID: 18157122]
    T-cell IC50
    < 20 μM
    Compound: 1, NSC-45383
    Inhibition of JAK-mediated IL6-induced Stat3 phosphorylation in BALB/c mouse CD8+ T cells by Phospho-Flow cytometry
    Inhibition of JAK-mediated IL6-induced Stat3 phosphorylation in BALB/c mouse CD8+ T cells by Phospho-Flow cytometry
    		[PMID: 18157122]
    T-cell IC50
    < 20 μM
    Compound: 1, NSC-45383
    Inhibition of JAK-mediated IL15-induced Stat5 phosphorylation in BALB/c mouse CD8+ T cells by Phospho-Flow cytometry
    Inhibition of JAK-mediated IL15-induced Stat5 phosphorylation in BALB/c mouse CD8+ T cells by Phospho-Flow cytometry
    		[PMID: 18157122]
    T-cell IC50
    < 20 μM
    Compound: 1, NSC-45383
    Inhibition of JAK-mediated IL7-induced Stat5 phosphorylation in BALB/c mouse CD8+ T cells by Phospho-Flow cytometry
    Inhibition of JAK-mediated IL7-induced Stat5 phosphorylation in BALB/c mouse CD8+ T cells by Phospho-Flow cytometry
    		[PMID: 18157122]
    T-cell IC50
    < 20 μM
    Compound: 1, NSC-45383
    Inhibition of JAK-mediated IL4-induced Stat6 phosphorylation in BALB/c mouse CD8+ T cells by Phospho-Flow cytometry
    Inhibition of JAK-mediated IL4-induced Stat6 phosphorylation in BALB/c mouse CD8+ T cells by Phospho-Flow cytometry
    		[PMID: 18157122]
    T-cell IC50
    < 20 μM
    Compound: 1, NSC-45383
    Inhibition of JAK-mediated IL4-induced Stat5 phosphorylation in BALB/c mouse CD8+ T cells by Phospho-Flow cytometry
    Inhibition of JAK-mediated IL4-induced Stat5 phosphorylation in BALB/c mouse CD8+ T cells by Phospho-Flow cytometry
    		[PMID: 18157122]
    XF498 IC50
    0.31 μg/mL
    Compound: 1
    Cytotoxicity against Homo sapiens (human) XF498 cells after 72 hr by MTT assay
    Cytotoxicity against Homo sapiens (human) XF498 cells after 72 hr by MTT assay
    		10.1007/s00044-004-0032-8
    XF498 IC50
    0.31 μg/mL
    Compound: Streptonigrin
    In vitro cytotoxic activity against XF 498 (CNS) using SRB (sulforhodamine B) assay
    In vitro cytotoxic activity against XF 498 (CNS) using SRB (sulforhodamine B) assay
    		[PMID: 10328288]
    分子量

    506.46

    Formula

    C25H22N4O8
    CAS 號
    性狀

    固體

    顏色

    Light brown to brown

    中文名稱

    鏈黑菌素；鏈黑霉素
    結(jié)構(gòu)分類
    初始來源

    Streptomyces flocculus
    運(yùn)輸條件

    Room temperature in continental US; may vary elsewhere.
    儲存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    純度 & 產(chǎn)品資料

    純度: 99.20%

    參考文獻(xiàn)

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    產(chǎn)品名稱：
    Streptonigrin
    目錄號：
    HY-124586
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