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  2. NF-κB
  3. NF-κB
  4. Quinoclamine

Quinoclamine  (Synonyms: 滅藻醌)

目錄號(hào): HY-121632 純度: 99.55%
COA 產(chǎn)品使用指南

Quinoclamine 是一種萘醌衍生物，是一種 NF-κB 抑制劑。Quinoclamine 具有抗腫瘤活性。

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Quinoclamine Chemical Structure

Quinoclamine Chemical Structure

CAS No. : 2797-51-5

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Other Forms of Quinoclamine:

MCE 顧客使用本產(chǎn)品發(fā)表的 2 篇科研文獻(xiàn)

查看 NF-κB 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Quinoclamine, a naphthoquinone derivative, is a NF-κB inhibitor. Quinoclamine exhibits anti-cancer activity[1][2].

IC50 & Target

NF-κB[2]
體外研究
(In Vitro)

Quinoclamine causes differentiation of U-937 cells into macrophage-like cells[1].
Quinoclamine inhibits NF-κB activities in HepG2 cells, with an IC50 of 1.7 μM[2].
Quinoclamine (1-4 μM; 30 minutes ) suppresses endogenous NF-κB activity in HepG2 cells through the inhibition of IκB-α phosphorylation and p65 translocation[2].
Quinoclamine inhibits induced NF-κB activities in lung and breast cancer cell lines[2].
Quinoclamine affects the expression levels of genes involved in cell cycle or apoptosis[2].
Quinoclamine down-regulates the expressions of UDP glucuronosyltransferase genes involved in phase II drug metabolism[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: HepG2 cells
Concentration: 1 μM, 2 μM, 4 μM, 8 μM, 16 μM, 32 μM, 64 μM
Incubation Time: