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  2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. Capillarisin

Capillarisin 作為蒿屬植物蒿的一種成分，具有抗炎和抗氧化作用。Capillarisin 可為哮喘介導(dǎo)并發(fā)癥的研究，并且可以作為一種潛在的神經(jīng)保護(hù)劑來(lái)對(duì)抗布比卡因引起的神經(jīng)毒性。

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Capillarisin Chemical Structure

Capillarisin Chemical Structure

CAS No. : 56365-38-9

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1 mg ￥5100
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Customer Review

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻(xiàn)

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Capillarisin, as a constituent from Artemisiae Capillaris herba, is found to exert anti-inflammatory and antioxidant properties. Capillarisin can be used for the research of asthma-mediated complications and can be a potential neuroprotectant against bupivacaine-induced neurotoxicity[1][2][3].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
HL-60 IC50
1.1 μg/mL
Compound: Capillarisin
Antiproliferative activity against human HL60 cells assessed as reduction in cell viability after 3 days by XTT assay
Antiproliferative activity against human HL60 cells assessed as reduction in cell viability after 3 days by XTT assay
[PMID: 31784199]
體外研究
(In Vitro)

Capillarisin (0~40 μM; 24 hours; SH-SY5Y cells) does not produce any significant changes on the viability of SH-SY5Y cells[3].
. Capillarisin (40 μM; 24 hours; SH-SY5Y cells) induces PI3K/PKB pathway inactivation, which inhibiting apoptosis in bupivacaine-challenged SH-SY5Y cells is overturned by LY294002 treatment and counteracts bupivacaine-induced injury via activating the PI3K/PKB pathway[3].
. Capillarisin antagonizes bupivacaine-induced oxidative stress via activating the PI3K/PKB pathway in SH-SY5Y cells. Capillarisin inhibits bupivacaine-induced mitochondrial injury and endoplasmic reticulum stress via activating PI3K/PKB pathway[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: SH-SY5Y cells
Concentration: 0~40 μM
Incubation Time: 24 hours
Result: Did not produce any significant changes on the viability of SH-SY5Y cells.

Western Blot Analysis[3]

Cell Line: SH-SY5Y cells
Concentration: 40 μM
Incubation Time: 24 hours
Result: Induced PI3K/PKB pathway inactivation in SH-SY5Y cells.

Apoptosis Analysis[3]

Cell Line: SH-SY5Y cells
Concentration: 40 μM
Incubation Time: 24 hours
Result: Induced inhibition of apoptosis in bupivacaine-challenged SH-SY5Y cells was overturned by LY294002 treatment.
體內(nèi)研究
(In Vivo)

Capillarisin (20 and 80 mg/kg; i.p.; 1 hour) pretreatment strongly inhibits NF-κB mediated genes (iNOS, COX-2)[4].
Capillarisin significantly reduces the plasma leading nitrite production. Capillarisin markedly suppresses the adenosine 5'-triphosphate (ATP) in plasma and substance P in CFA-induced paw tissue[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice[4]
Dosage: 20 and 80 mg/kg
Administration: I.p.; 1 hour
Result: Pretreatment strongly inhibited NF-κB mediated genes (iNOS, COX-2).
分子量

316.26

Formula

C16H12O7
CAS 號(hào)
性狀

固體

顏色

Light yellow to yellow

結(jié)構(gòu)分類(lèi)
初始來(lái)源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 13 mg/mL (41.11 mM; 超聲加熱助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 3.1620 mL 15.8098 mL 31.6196 mL
5 mM 0.6324 mL 3.1620 mL 6.3239 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
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體積
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分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

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給藥劑量

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計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.27%

參考文獻(xiàn)