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  2. Anti-infection Cell Cycle/DNA Damage
  3. Bacterial Topoisomerase Antibiotic
  4. Zabofloxacin

Zabofloxacin  (Synonyms: DW-224a Free base)

目錄號(hào): HY-106410
COA 產(chǎn)品使用指南

Zabofloxacin (DW-224a Free base) 是一種有效的、對(duì)細(xì)菌 II 型和 IV 型拓?fù)洚悩?gòu)酶 (type II and IV topoisomerases) 有效的抑制劑。Zabofloxacin 對(duì)革蘭氏陽性致病菌包括金黃色葡萄球菌、化膿性鏈球菌和肺炎鏈球菌有良好的抗菌活性。Zabofloxacin 是一種新型氟萘啶酮喹諾酮類抗生素，被認(rèn)為是研究喹諾酮易感 (QSSP) 和喹諾酮耐藥淋病 (QRSP) 的替代試劑。

在相同的摩爾濃度下，化合物鹽形式與游離形式有相同的生物活性，但鹽形式 Zabofloxacin hydrochloride 通常具有更好的水溶性和穩(wěn)定性。

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Zabofloxacin Chemical Structure

Zabofloxacin Chemical Structure

CAS No. : 219680-11-2

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規(guī)格 價(jià)格 是否有貨
1 mg ￥2760
詢問價(jià)格 & 貨期
5 mg 現(xiàn)貨 詢問價(jià)格 & 貨期

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Zabofloxacin 的其他形式現(xiàn)貨產(chǎn)品:

Customer Review

Other Forms of Zabofloxacin:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Zabofloxacin (DW-224a Free base) is a potent and seletive inhibitor of the bacterial type II and IV topoisomerases. Zabofloxacin has excellent activity against gram-positive pathogens including?Steptococcus aureus,?Streptococcus pyogenes?and?S.pneumonia. Zabofloxacin is a novel fluoronaphthyridone quinolone that is considered as an alternative antibiotic for treatment of quinolone-susceptible (QSSP) and quinolone-resistant gonorrhea (QRSP)[1].

IC50 & Target[1]

Topoisomerase I

 

Topoisomerase II

 

Quinolone

 

體外研究
(In Vitro)

Zabofloxacin shows a highly potent in vitro activity against clinical isolates of penicillin-sensitive?S. pneumoniae?(minimum inhibitory concentration, MIC90: 0.03 mg/L) and penicillin-resistant?S. pneumoniae?(MIC90: 0.03 mg/L). Against quinolone-resistant?S. pneumoniae,?zabofloxacin (MIC90: 1 mg/L) is more active than ciprofloxacin, sparfloxacin, and moxifloxacin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

401.39

Formula

C19H20FN5O4
CAS 號(hào)
性狀

固體

顏色

White to off-white

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料

純度: 98.02%

參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Zabofloxacin
目錄號(hào)：
HY-106410
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