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  2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. BW-180C

BW-180C  (Synonyms: [D-Ala2, D-Leu5]-Enkephalin; DADLE)

目錄號(hào): HY-105343 純度: 99.92%
COA 產(chǎn)品使用指南

BW-180C ([D-Ala2, D-Leu5]-Enkephalin; DADLE) 是一種 δ 阿片受體 (DOR) 激動(dòng)劑，屬于腦啡肽家族，是一種神經(jīng)保護(hù)劑。BW-180C 可逆地抑制神經(jīng)元的細(xì)胞轉(zhuǎn)錄而不引起細(xì)胞損傷。

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Custom Peptide Synthesis

BW-180C Chemical Structure

BW-180C Chemical Structure

CAS No. : 63631-40-3

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥772
In-stock
5 mg ￥616
In-stock
10 mg ￥960
In-stock
25 mg ￥1920
In-stock
50 mg ￥3120
In-stock
100 mg ￥4720
In-stock
200 mg   詢價(jià)  
500 mg   詢價(jià)  

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MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻(xiàn)

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

BW-180C ([D-Ala2, D-Leu5]-Enkephalin; DADLE) is an δ opioid receptor (DOR) agonist, which belongs to the enkephalin family. Neuroprotective agent. BW-180C reversibly inhibits cellular transcription in neurons without causing cell injury[1].

IC50 & Target

Opioid Receptor[1]
細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 EC50
1.3 μM
Compound: DADLE
Agonist activity at GFP-fused mu opioid receptor (unknown origin) expressed in HEK293 cells assessed as recruitment of beta-arrestin-2 after 10 mins by BRET assay
Agonist activity at GFP-fused mu opioid receptor (unknown origin) expressed in HEK293 cells assessed as recruitment of beta-arrestin-2 after 10 mins by BRET assay
[PMID: 24613457]
HEK293 EC50
54 nM
Compound: DADLE
Agonist activity at GFP-fused delta opioid receptor (unknown origin) expressed in HEK293 cells assessed as recruitment of beta-arrestin-2 after 10 mins by BRET assay
Agonist activity at GFP-fused delta opioid receptor (unknown origin) expressed in HEK293 cells assessed as recruitment of beta-arrestin-2 after 10 mins by BRET assay
[PMID: 24613457]
體外研究
(In Vitro)

"Pretreatment with BW-180C (DADLE) dose-dependently enhances survival of neurons in the central nervous system. BW-180C is able to induce a reversible hibernation-like state in HeLa cells, a cell line derived from cervical cancer cells, by inhibiting transcription and proliferation in these cells[1].
BW-180C (100 pM to 10 μM) inhibits cellular transcription by ~50% by 24 h compared with vehicle-treated controls[1].
BW-180C does not affect total RNA polymerase II expression. DADLE inhibits phosphorylation of RNA polymerase II in primary cortical neurons[1]. "

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Human neuroblastoma cells, SH-SY5Y cells
Concentration: 100 pM to 10 μM
Incubation Time: 24-72 hours
Result: Significantly inhibited cellular transcription.

Western Blot Analysis[1]

Cell Line: Primary cortical neurons
Concentration: 100 nM
Incubation Time: 72 hours
Result: Treatment significantly decreased phosphorylation of RNA polymerase II at both Ser 2 and Ser 5.
體內(nèi)研究
(In Vivo)

BW-180C ( [D-Ala2, D-Leu5]-Enkephalin; DADLE) protects liver against ischemia-reperfusion injury in the rat. DADLE (5 mg/kg) protects the heart, lung, and jejunum against ischemia-reperfusion (I-R) injury[2].
BW-180C (DADLE) improves hepatic ischemia/reperfusion injury in mice via activation of the Nrf2/HO1 pathway[3].
DADLE (5 mg/kg) significantly reduces the levels of alanine aminotransferase and aspartate aminotransferase in the serum, and the levels of malondialdehyde in the liver homogenate[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighing 200 to 250 g[2]
Dosage: 5 mg/kg
Administration: Administered intravenously into the inferior vena cava
Result: After 120 min of reperfusion, the serum GPT levels were significantly lower in the DADLE group than in the Control group.
Animal Model: Male C57BL/6 mice (age, 35-42 days; weight, 18-22 g; 6 mice in each group)[3]
Dosage: 5 mg/kg
Administration: Injected intraperitoneally 15 min prior to I/R
Result: The serum levels of AST and ALT in the serum DADLE group were significantly lower.
分子量

569.65

Formula

C29H39N5O7
CAS 號(hào)
性狀

固體

顏色

White to off-white

中文名稱

[D-Ala2, D-Leu5]-腦啡肽
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 250 mg/mL (438.87 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 1.7555 mL 8.7773 mL 17.5546 mL
5 mM 0.3511 mL 1.7555 mL 3.5109 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.92%

參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7555 mL 8.7773 mL 17.5546 mL 43.8866 mL
5 mM 0.3511 mL 1.7555 mL 3.5109 mL 8.7773 mL
10 mM 0.1755 mL 0.8777 mL 1.7555 mL 4.3887 mL
15 mM 0.1170 mL 0.5852 mL 1.1703 mL 2.9258 mL
20 mM 0.0878 mL 0.4389 mL 0.8777 mL 2.1943 mL
25 mM 0.0702 mL 0.3511 mL 0.7022 mL 1.7555 mL
30 mM 0.0585 mL 0.2926 mL 0.5852 mL 1.4629 mL
40 mM 0.0439 mL 0.2194 mL 0.4389 mL 1.0972 mL
50 mM 0.0351 mL 0.1755 mL 0.3511 mL 0.8777 mL
60 mM 0.0293 mL 0.1463 mL 0.2926 mL 0.7314 mL
80 mM 0.0219 mL 0.1097 mL 0.2194 mL 0.5486 mL
100 mM 0.0176 mL 0.0878 mL 0.1755 mL 0.4389 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
BW-180C
目錄號(hào)：
HY-105343
需求量：