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  2. GPCR/G Protein
  3. G protein-coupled Bile Acid Receptor 1
  4. SB756050

SB756050 是選擇性的 TGR5 激動劑。SB756050有潛力用于二型糖尿病的研究。

MCE 的所有產(chǎn)品僅用作科學研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務(wù)

SB756050 Chemical Structure

SB756050 Chemical Structure

CAS No. : 447410-57-3

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2.  同一機構(gòu)（單位）同一產(chǎn)品試用裝僅限申領(lǐng)一次，同一機構(gòu)（單位）一年內(nèi)

     可免費申領(lǐng)三個不同產(chǎn)品的試用裝。

3.  試用裝只面向終端客戶。

規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥319
In-stock
5 mg ￥290
In-stock
10 mg ￥435
In-stock
25 mg ￥740
In-stock
50 mg ￥1100
In-stock
100 mg   詢價  
200 mg   詢價  

* Please select Quantity before adding items.

Customer Review

MCE 顧客使用本產(chǎn)品發(fā)表的 2 篇科研文獻

WB

    SB756050 purchased from MCE. Usage Cited in: Cell Death Discov. 2020 Jul 6;6:56.  [Abstract]

    GES-1 cells are treated with SB756050 (2, 5, and 10?μM) for 24?h. KLF4 and CDX2 protein expression is examined by WB. The results show that KLF4 and CDX2 expression is significantly increased.

    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻

    生物活性

    SB756050 is a selective TGR5 agonist. SB756050 has the potential for type 2 diabetes treatment.

    體外研究
    (In Vitro)

    TGR5 is a bile acid receptor and a potential target for the treatment of type 2 diabetes (T2D)[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    體內(nèi)研究
    (In Vivo)

    SB756050 is well‐tolerated; it is readily absorbed, exhibited nonlinear pharmacokinetics with a less than dose‐proportional increase in plasma exposure above 100 mg, and demonstrates no significant changes in exposure when co‐administered with sitagliptin. SB756050 demonstrates highly variable pharmacodynamic effects both within dose groups and between doses, with increases in glucose seen at the two lowest doses and no reduction in glucose seen at the two highest doses. The glucose effects of SB756050 sitagliptin are comparable to those of sitagliptin alone, even though gut hormone plasma profiles are different[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    分子量

    500.59

    Formula

    C21H28N2O8S2
    CAS 號
    性狀

    固體

    顏色

    White to off-white

    運輸條件

    Room temperature in continental US; may vary elsewhere.
    儲存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    溶解性數(shù)據(jù)
    細胞實驗： 

    DMSO 中的溶解度 : ≥ 150 mg/mL (299.65 mM; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

    * "≥" means soluble, but saturation unknown.

    配制儲備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 1.9976 mL 9.9882 mL 19.9764 mL
    5 mM 0.3995 mL 1.9976 mL 3.9953 mL
    查看完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用， -20°C儲存時，請在1年內(nèi)使用。

    • 摩爾計算器

    • 稀釋計算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動物溶解方案計算器
    請輸入動物實驗的基本信息：

    給藥劑量

    mg/kg

    動物的平均體重

    g

    每只動物的給藥體積

    μL

    動物數(shù)量

    只
    由于實驗過程有損耗，建議您多配一只動物的量
    計算結(jié)果
    工作液所需濃度 : mg/mL
    純度 & 產(chǎn)品資料
    參考文獻

    完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用， -20°C儲存時，請在1年內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.9976 mL 9.9882 mL 19.9764 mL 49.9411 mL
    5 mM 0.3995 mL 1.9976 mL 3.9953 mL 9.9882 mL
    10 mM 0.1998 mL 0.9988 mL 1.9976 mL 4.9941 mL
    15 mM 0.1332 mL 0.6659 mL 1.3318 mL 3.3294 mL
    20 mM 0.0999 mL 0.4994 mL 0.9988 mL 2.4971 mL
    25 mM 0.0799 mL 0.3995 mL 0.7991 mL 1.9976 mL
    30 mM 0.0666 mL 0.3329 mL 0.6659 mL 1.6647 mL
    40 mM 0.0499 mL 0.2497 mL 0.4994 mL 1.2485 mL
    50 mM 0.0400 mL 0.1998 mL 0.3995 mL 0.9988 mL
    60 mM 0.0333 mL 0.1665 mL 0.3329 mL 0.8324 mL
    80 mM 0.0250 mL 0.1249 mL 0.2497 mL 0.6243 mL
    100 mM 0.0200 mL 0.0999 mL 0.1998 mL 0.4994 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Inquiry Information

    產(chǎn)品名稱：
    SB756050
    目錄號：
    HY-102016
    需求量：