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Bleomycin sulfate

別名: NSC125066 sulfate 中文名稱：硫酸博來霉素

Bleomycin Sulfate硫酸博來霉素是一種糖肽類抗生素，一種DNA 合成抑制劑，也是一種鱗狀細(xì)胞癌(SCC)抗癌劑，在UT-SCC-19A細(xì)胞中IC50為4 nM。Bleomycin sulfate是一種DNA 合成抑制劑。

Bleomycin sulfate Chemical Structure

Bleomycin sulfate Chemical Structure

CAS: 9041-93-4

規(guī)格 價(jià)格 庫(kù)存 購(gòu)買數(shù)量
10mg 1630.13 現(xiàn)貨
50mg 4889.43 現(xiàn)貨
200mg 12203.1 現(xiàn)貨
1g 40704.3 現(xiàn)貨
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常與Bleomycin sulfate一起在實(shí)驗(yàn)中被使用的化合物

Lomustine

Bleomycin sulfate和Lomustine治療轉(zhuǎn)移性睪丸癌有益。

Sonntag RW, et al. Cancer Chemother Rep. 1975 Mar-Apr;59(2 Pt 1):429-31.

Cisplatin

Bleomycin sulfate和Cisplatin聯(lián)合抑制DNA合成，導(dǎo)致小鼠胚胎成纖維細(xì)胞死亡。

Hussain SS, et al. Chemotherapy. 1988;34(6):504-11.

Carboplatin

Bleomycin sulfate和Carboplatin聯(lián)合抑制DNA合成，導(dǎo)致小鼠胚胎成纖維細(xì)胞死亡。

Hussain SS, et al. Chemotherapy. 1988;34(6):504-11.

Doxorubicin

Bleomycin (NSC125066) sulfate和Doxorubicin對(duì)化學(xué)誘導(dǎo)的大鼠前胃和膀胱腫瘤有較好的治療效果。

Tormey DC, et al. Cancer Chemother Rep. 1973 Nov-Dec;57(4):413-8.

Vinblastine sulfate

Bleomycin (NSC125066) sulfate和Vinblastine聯(lián)合治療不可切除的非小細(xì)胞肺癌(NSCLC)有效。

Chlebowski RT, et al. J Clin Oncol. 1990 Jan;8(1):9-15.

Bleomycin sulfate相關(guān)產(chǎn)品

細(xì)胞實(shí)驗(yàn)數(shù)據(jù)示例

細(xì)胞系 實(shí)驗(yàn)類型 給藥濃度 孵育時(shí)間 活性描述 文獻(xiàn)信息
MDA-MB-235? PDT/PCI Treatment 0.25 μg/ml. 1-4 h shows significant (P?< 0.05) cytotoxic effect 22591284
MDA-MB-231 PDT/PCI Treatment 0.25 μg/ml. 1-4 h shows significant (P?< 0.05) cytotoxic effect 22591284
MCF-7 PDT/PCI Treatment 0.25 μg/ml. 1-4 h shows significant (P?< 0.05) cytotoxic effect 22591284
MCF-7/Her-18? Growth Inhibition Assay 0.42-1700 μg/mL 24 h inhibits cell growth dose dependently 22621404
A549? Function Assay 100 μM? 0–48 h decreases MMP and ATP levels 22773697
A549? Function Assay 100 μM? 0–48 h causes mitochondrial localization of Bax 22773697
A549? Function Assay 100 μM? 0–48 h causes PKD1 cleavage 22773697
A549? Function Assay 100 μM? 0–48 h causes caspase-3 activation 22773697
A549? Function Assay 0-400 μM 2-48 h causes more mtDNA than nDNA damage 22773697
231-H2N Growth Inhibition Assay 0–200?μg/mL 24 h inhibits cell growth dose dependently 22819196
MDA-MB-468 Growth Inhibition Assay 0–200?μg/mL 24 h inhibits cell growth dose dependently 22819196
NCCIT Function Assay 120 μg/ml 72 h significantly increases LPO levels 22825355
NTera-2 Function Assay 120 μg/ml 72 h significantly increases LPO levels 22825355
NCCIT Function Assay 120 μg/ml 72 h significantly increases Protein carbonyl levels 22825355
NTera-2 Function Assay 120 μg/ml 72 h significantly increases Protein carbonyl levels 22825355
NCCIT Function Assay 120 μg/ml 72 h significantly decreases GSH levels 22825355
NCCIT Function Assay 120 μg/ml 72 h significantly increases TBARS levels 22825355
NTera-2 Function Assay 120 μg/ml 72 h significantly increases TBARS levels 22825355
NCCIT Function Assay 120 μg/ml 72 h significantly increases 8-isoprostane levels 22825355
NTera-2 Function Assay 120 μg/ml 72 h significantly increases 8-isoprostane levels 22825355
NT2? Apoptosis Assay 400?μg/ml 24 h? induces significant increases in caspase-3,8,9 activity? 23386420
NCM460 Growth Inhibition Assay 0-100 μg/ml 48 h inhibits cell growth dose dependently 23518201
HCT116 Growth Inhibition Assay 0-100 μg/ml 48 h inhibits cell growth dose dependently 23518201
HeLa Apoptosis Assay 3/7.5/15 μg/ml 48 h reduces the level of BLH at high concentration 23708668
HCT-116 Apoptosis Assay 3/7.5/15 μg/ml 48 h reduces the level of BLH at high concentration 23708668
A549 Growth Inhibition Assay 200 μM 24 h? decreases cell viability significantly 23805793
MMP1 Apoptosis Assay 10 mU 48 h induces apoptosis 23902766
MOCK Apoptosis Assay 10 mU 48 h induces apoptosis 23902766
A459 Apoptosis Assay 10 mU 48 h induces apoptosis 23902766
BMG-1? Growth Inhibition Assay 40/80?μg/m 3?h inhibits cell growth dose dependently 23906726
Jurkat Growth Inhibition Assay 20?μm 24?h? arrests the cell cycle at the G2 phase 24916893
MLE12 Function Assay 1 μg/mL? 0-48 h increases the expression of?OPN?mRNA 24963635
A549 Function Assay 1 μg/mL? 0-48 h increases the expression of?OPN?mRNA 24963635
AY-27? Growth Inhibition Assay 50-200 IU 48?h inhibits cell growth dose dependently 25101299
T24 Growth Inhibition Assay 50-200 IU 48?h inhibits cell growth dose dependently 25101299
A431 Growth Inhibition Assay 50-200 IU 48?h inhibits cell growth dose dependently 25101299
HT1080 Function Assay 1 μM 24 h? induces a potent global DNA damage response 25518961
HT1080 Growth Inhibition Assay 1 μM 24 h? leads to a G2/M delay 25518961
IMR-32 Growth Inhibition Assay 7.5?120 μg/ml 12?48 h IC50=60 μg/ml at the end of 24 hrs of incubation 25536345
PMCs Function Assay 0.2?μg/ml 12/24/48 h increases cell migration 25595642
PMCs Function Assay 0.2?μg/ml 72 h induces decreases in cytokeratin-8 and E-cadherin protein 25595642
PMCs Function Assay 0.2?μg/ml 24–72?h induces increases in vimentin and α-SMA protein 25595642
PMCs Function Assay 0.1–2?μg/ml 24?h causes a dose-dependent increase in the protein level of collagen-I? 25595642
RLE/Abca3 Function Assay 0.4?μM 144?h induces a morphological change from epithelial-like morphology to a wide, spread-out morphology? 25760538
F98 Growth Inhibition Assay 0–1000 μm 24 h? inhibits cell growth dose dependently 26088711
MCF-7 Growth Inhibition Assay 0-2 μg/ml. 24/48 h EC50=1.2 μg/mL 22591284
NCCIT? Growth Inhibition Assay 20–140?μg/ml 72 h LD50=120?μg/ml? 22562160
HeLa Function Assay 30/70 μg/ml 24?h increases the mRNA levels of?p53，ATM,p21?and?GADD45 22487937
MCF-7? Function Assay 30/70 μg/ml 24?h increases the mRNA levels of?p53，ATM,p21?and?GADD45 22487937
HeLa Cytotoxicity Assay 30/70 μg/ml 24?h induces highly significant levels of fragmented DNA release into the cytoplasm 22487937
MCF-7? Cytotoxicity Assay 30/70 μg/ml 24?h induces highly significant levels of fragmented DNA release into the cytoplasm 22487937
NT2 Growth Inhibition Assay 100-600?μg/ml 24 h IC50=400 μg/ml 22469952
NT2 Function Assay 400?μg/ml 24 h significantly increases caspase-3,8,9 activity? 22469952
NT2 Function Assay 400?μg/ml 24 h significantly increases BAX level 22469952
NT2 Function Assay 400?μg/ml 24 h significantly decreases Bcl-2 level 22469952
CHO Function Assay 2.5?μg/ml 18 h/6 d induces?persistence of chromosome damage 22230195
Jurkat Growth Inhibition Assay 0-100?μg/ml 24 h arrests the cell cycle at the G2 phase 22223332
Jurkat Function Assay 30?μg/ml 24 h increases the protein levels of cyclins D3, A and B1 22223332
Jurkat Growth Inhibition Assay 0-100?μg/ml 24 h inhibits cell proliferation in a dose-dependent manner with an IC50 value of 100μg/mL 22223332
Jurkat Function Assay 30?μg/ml 24 h increases the effect of pycnidione on phosphorylation levels of histone H2A.X 22223332
U2OS EGFPnls Growth Inhibition Assay 0-2?μg/ml 24 h inhibits cell growth dose dependently 21811007
U2OS KuEnls Growth Inhibition Assay 0-2?μg/ml 24 h inhibits cell growth dose dependently 21811007
MCF-7 Growth Inhibition Assay 0-400 μM 72 h LC50=151.8?μM 21703291
MCF-7/Adr? Growth Inhibition Assay 0-400 μM 72 h LC50=58.5?μM? 21703291
WI-38 Function Assay 0/40/80?μg/ml? 3 h induces a concentration-dependent increase in the MN frequency? 21599612
hBMSC Function Assay 0/40/80?μg/ml? 3 h induces a concentration-dependent increase in the MN frequency? 21599612
NCI-H23 Function Assay 0/40/80?μg/ml? 3 h induces a concentration-dependent increase in the MN frequency? 21599612
A-549 Function Assay 0/40/80?μg/ml? 3 h induces a concentration-dependent increase in the MN frequency? 21599612
PBL? Function Assay 0/40/80?μg/ml? 3 h induces a concentration-dependent increase in the MN frequency? 21599612
pol β ?/? Growth Inhibition Assay 0.25-200?μg/ml 24?h decreases cell viability with increasing concentrations? 21251944
pol β +/+ Growth Inhibition Assay 0.25-200?μg/ml 24?h decreases cell viability with increasing concentrations? 21251944
pol β ?/? Function Assay 0-2.5 μg/ml 2 h causes DNA damage 21251944
pol β +/+ Function Assay 0-2.5 μg/ml 2 h causes DNA damage 21251944
pol β ?/? Function Assay 0-5 μg/ml 48 h causes micronucleus dose and time dependently 21251944
pol β +/+ Function Assay 0-5 μg/ml 48 h causes micronucleus dose and time dependently 21251944
TK6? Growth Inhibition Assay 25-150 μg/ml 96 h inhibits cell growth dose dependently 21081487
TK6? sLUC+Apn1 Growth Inhibition Assay 25-150 μg/ml 96 h inhibits cell growth dose dependently 21081487
TK6 sAPE1+Apn1 Growth Inhibition Assay 25-150 μg/ml 96 h significantly inhibits cell growth dose dependently 21081487
HCT116 Growth Inhibition Assay 25-150 μg/ml 96 h inhibits cell growth dose dependently 21081487
HCT116 sLUC+Apn1 Growth Inhibition Assay 25-150 μg/ml 96 h inhibits cell growth dose dependently 21081487
HCT116 sAPE1+Apn1 Growth Inhibition Assay 25-150 μg/ml 96 h significantly inhibits cell growth dose dependently 21081487
A549? Function Assay 200/400 μM results in a dose-responsive increase in ROS 22773697
C18-4 Growth Inhibition Assay 0-100 μM inhibits cell growth dose dependently 24571982
NT2? Growth Inhibition Assay 72 h LD50=20?μg/ml 23386420
NT2? Growth Inhibition Assay 48 h LD50=100 μg/ml 23386420
NT2? Growth Inhibition Assay 24 h? LD50=400?μg/ml 23386420
HCT116? Cytotoxicity Assay 72 h IC50=11.34% 25276792
HT-29 Cytotoxicity Assay 72 h IC50=11.49% 25276792
THP-1 Cytotoxicity Assay 72 h IC50=4.77% 25276792
HDFn Cytotoxicity Assay 72 h IC50=9.31%? 25276792
NCCIT? Function Assay 72 h significantly increases caspase-3 activity? 22562160
NCCIT? Function Assay 72 h significantly increases caspase-8 activity? 22562160
NCCIT? Function Assay 72 h significantly increases caspase-9 activity? 22562160
NCCIT? Function Assay 72 h significantly increases BAX level 22562160
NCCIT? Function Assay 72 h significantly decreases the Bcl-2 content 22562160
NCCIT? Function Assay 72 h significantly decreases the Cyt-c level 22562160
2SC/20 Function Assay 72 h IC50 = 0.517 μM 12431060
HET-SR-2SC-LNM Function Assay 72 h IC50 = 0.519 μM 12431060
MCF-7 Function Assay 24 h IC50 = 53 μM 12477361
HeLa? Growth Inhibition Assay IC50=10.2?μM 24732397
POLK CD Growth Inhibition Assay IC50=5.59?±?1.00?μM 26031400
POLK KO Growth Inhibition Assay IC50=4.03?±?1.92?μM 26031400
POLK WT Growth Inhibition Assay IC50=11.7?±?1.7?μM 26031400
HepG2 Growth Inhibition Assay GI50 = 1 μM 18068362
COLO-668 Growth Inhibition Assay IC50 = 0.0000218 μM SANGER
CAL-51 Growth Inhibition Assay IC50 = 0.000099 μM SANGER
A427 Growth Inhibition Assay IC50 = 0.000118 μM SANGER
RMG-I Growth Inhibition Assay IC50 = 0.0001319 μM SANGER
HUTU-80 Growth Inhibition Assay IC50 = 0.0001358 μM SANGER
NTERA-S-cl-D1 Growth Inhibition Assay IC50 = 0.0001391 μM SANGER
IST-SL2 Growth Inhibition Assay IC50 = 0.0001732 μM SANGER
CAL-85-1 Growth Inhibition Assay IC50 = 0.0001777 μM SANGER
SUP-T1 Growth Inhibition Assay IC50 = 0.000251 μM SANGER
HCC1937 Growth Inhibition Assay IC50 = 0.000254 μM SANGER
CAL-39 Growth Inhibition Assay IC50 = 0.0003147 μM SANGER
HAL-01 Growth Inhibition Assay IC50 = 0.0004527 μM SANGER
OVCAR-8 Growth Inhibition Assay IC50 = 0.0004763 μM SANGER
CESS Growth Inhibition Assay IC50 = 0.0005457 μM SANGER
NCI-H650 Growth Inhibition Assay IC50 = 0.0005873 μM SANGER
MKN28 Growth Inhibition Assay IC50 = 0.00108 μM SANGER
RS4-11 Growth Inhibition Assay IC50 = 0.001643 μM SANGER
MFH-ino Growth Inhibition Assay IC50 = 0.002646 μM SANGER
KYSE-150 Growth Inhibition Assay IC50 = 0.002647 μM SANGER
KGN Growth Inhibition Assay IC50 = 0.003712 μM SANGER
HOP-62 Growth Inhibition Assay IC50 = 0.004134 μM SANGER
LU-99A Growth Inhibition Assay IC50 = 0.00422 μM SANGER
RT4 Growth Inhibition Assay IC50 = 0.005856 μM SANGER
SK-UT-1 Growth Inhibition Assay IC50 = 0.006293 μM SANGER
HCC2998 Growth Inhibition Assay IC50 = 0.006592 μM SANGER
GT3TKB Growth Inhibition Assay IC50 = 0.00685 μM SANGER
EW-16 Growth Inhibition Assay IC50 = 0.006853 μM SANGER
NKM-1 Growth Inhibition Assay IC50 = 0.007647 μM SANGER
HCC1806 Growth Inhibition Assay IC50 = 0.008543 μM SANGER
SW954 Growth Inhibition Assay IC50 = 0.009572 μM SANGER
MV-4-11 Growth Inhibition Assay IC50 = 0.009908 μM SANGER
LOUCY Growth Inhibition Assay IC50 = 0.009935 μM SANGER
KS-1 Growth Inhibition Assay IC50 = 0.01084 μM SANGER
NMC-G1 Growth Inhibition Assay IC50 = 0.01185 μM SANGER
REH Growth Inhibition Assay IC50 = 0.01339 μM SANGER
NCI-H2342 Growth Inhibition Assay IC50 = 0.01383 μM SANGER
BFTC-909 Growth Inhibition Assay IC50 = 0.01383 μM SANGER
EFM-19 Growth Inhibition Assay IC50 = 0.01477 μM SANGER
NCI-H1703 Growth Inhibition Assay IC50 = 0.01612 μM SANGER
BB30-HNC Growth Inhibition Assay IC50 = 0.01634 μM SANGER
NCI-H1734 Growth Inhibition Assay IC50 = 0.01742 μM SANGER
SF295 Growth Inhibition Assay IC50 = 0.02139 μM SANGER
MKN45 Growth Inhibition Assay IC50 = 0.02481 μM SANGER
ES1 Growth Inhibition Assay IC50 = 0.0267 μM SANGER
NEC8 Growth Inhibition Assay IC50 = 0.02685 μM SANGER
CTB-1 Growth Inhibition Assay IC50 = 0.02694 μM SANGER
5637 Growth Inhibition Assay IC50 = 0.02897 μM SANGER
SR Growth Inhibition Assay IC50 = 0.02967 μM SANGER
HCC38 Growth Inhibition Assay IC50 = 0.03124 μM SANGER
LB1047-RCC Growth Inhibition Assay IC50 = 0.03255 μM SANGER
ES4 Growth Inhibition Assay IC50 = 0.03826 μM SANGER
MHH-ES-1 Growth Inhibition Assay IC50 = 0.04357 μM SANGER
LS-411N Growth Inhibition Assay IC50 = 0.05276 μM SANGER
HT-144 Growth Inhibition Assay IC50 = 0.05514 μM SANGER
BPH-1 Growth Inhibition Assay IC50 = 0.05909 μM SANGER
HMV-II Growth Inhibition Assay IC50 = 0.06974 μM SANGER
A375 Growth Inhibition Assay IC50 = 0.0711 μM SANGER
LoVo Growth Inhibition Assay IC50 = 0.07117 μM SANGER
COR-L23 Growth Inhibition Assay IC50 = 0.07548 μM SANGER
G-402 Growth Inhibition Assay IC50 = 0.07651 μM SANGER
CCRF-CEM Growth Inhibition Assay IC50 = 0.07869 μM SANGER
MKN1 Growth Inhibition Assay IC50 = 0.07965 μM SANGER
LC-2-ad Growth Inhibition Assay IC50 = 0.08036 μM SANGER
ETK-1 Growth Inhibition Assay IC50 = 0.0805 μM SANGER
786-0 Growth Inhibition Assay IC50 = 0.08084 μM SANGER
SW13 Growth Inhibition Assay IC50 = 0.08162 μM SANGER
Daoy Growth Inhibition Assay IC50 = 0.08304 μM SANGER
G-361 Growth Inhibition Assay IC50 = 0.08831 μM SANGER
HCT-15 Growth Inhibition Assay IC50 = 0.0951 μM SANGER
ARH-77 Growth Inhibition Assay IC50 = 0.10452 μM SANGER
NCI-H1299 Growth Inhibition Assay IC50 = 0.10753 μM SANGER
MEL-JUSO Growth Inhibition Assay IC50 = 0.10855 μM SANGER
MIA-PaCa-2 Growth Inhibition Assay IC50 = 0.11074 μM SANGER
769-P Growth Inhibition Assay IC50 = 0.1228 μM SANGER
MZ7-mel Growth Inhibition Assay IC50 = 0.1305 μM SANGER
KG-1 Growth Inhibition Assay IC50 = 0.13057 μM SANGER
23132-87 Growth Inhibition Assay IC50 = 0.13146 μM SANGER
ML-2 Growth Inhibition Assay IC50 = 0.13166 μM SANGER
BOKU Growth Inhibition Assay IC50 = 0.13698 μM SANGER
SW1573 Growth Inhibition Assay IC50 = 0.13715 μM SANGER
IMR-5 Growth Inhibition Assay IC50 = 0.13736 μM SANGER
PSN1 Growth Inhibition Assay IC50 = 0.13888 μM SANGER
LCLC-103H Growth Inhibition Assay IC50 = 0.14398 μM SANGER
IGROV-1 Growth Inhibition Assay IC50 = 0.14455 μM SANGER
CHP-212 Growth Inhibition Assay IC50 = 0.14774 μM SANGER
RH-1 Growth Inhibition Assay IC50 = 0.15221 μM SANGER
MFE-296 Growth Inhibition Assay IC50 = 0.15324 μM SANGER
NCI-H2170 Growth Inhibition Assay IC50 = 0.16242 μM SANGER
Saos-2 Growth Inhibition Assay IC50 = 0.17196 μM SANGER
LB996-RCC Growth Inhibition Assay IC50 = 0.17534 μM SANGER
LB2518-MEL Growth Inhibition Assay IC50 = 0.18225 μM SANGER
PC-14 Growth Inhibition Assay IC50 = 0.18269 μM SANGER
ESS-1 Growth Inhibition Assay IC50 = 0.18744 μM SANGER
CAL-54 Growth Inhibition Assay IC50 = 0.19067 μM SANGER
A204 Growth Inhibition Assay IC50 = 0.20037 μM SANGER
639-V Growth Inhibition Assay IC50 = 0.21956 μM SANGER
A2780 Growth Inhibition Assay IC50 = 0.22019 μM SANGER
MZ1-PC Growth Inhibition Assay IC50 = 0.22434 μM SANGER
GDM-1 Growth Inhibition Assay IC50 = 0.22845 μM SANGER
HT-1080 Growth Inhibition Assay IC50 = 0.23357 μM SANGER
SK-CO-1 Growth Inhibition Assay IC50 = 0.24652 μM SANGER
SW1783 Growth Inhibition Assay IC50 = 0.24925 μM SANGER
PANC-10-05 Growth Inhibition Assay IC50 = 0.25606 μM SANGER
CAL-12T Growth Inhibition Assay IC50 = 0.25851 μM SANGER
VA-ES-BJ Growth Inhibition Assay IC50 = 0.26047 μM SANGER
MDA-MB-231 Growth Inhibition Assay IC50 = 0.27307 μM SANGER
IST-MEL1 Growth Inhibition Assay IC50 = 0.27975 μM SANGER
GAMG Growth Inhibition Assay IC50 = 0.28935 μM SANGER
EW-13 Growth Inhibition Assay IC50 = 0.29208 μM SANGER
SW1710 Growth Inhibition Assay IC50 = 0.29533 μM SANGER
C3A Growth Inhibition Assay IC50 = 0.29644 μM SANGER
PANC-03-27 Growth Inhibition Assay IC50 = 0.31639 μM SANGER
H4 Growth Inhibition Assay IC50 = 0.32074 μM SANGER
NCI-H358 Growth Inhibition Assay IC50 = 0.37271 μM SANGER
ACHN Growth Inhibition Assay IC50 = 0.37463 μM SANGER
TE-8 Growth Inhibition Assay IC50 = 0.37669 μM SANGER
SK-MEL-30 Growth Inhibition Assay IC50 = 0.37688 μM SANGER
ES7 Growth Inhibition Assay IC50 = 0.37754 μM SANGER
DoTc2-4510 Growth Inhibition Assay IC50 = 0.37834 μM SANGER
C-4-II Growth Inhibition Assay IC50 = 0.38131 μM SANGER
SNU-449 Growth Inhibition Assay IC50 = 0.38851 μM SANGER
GB-1 Growth Inhibition Assay IC50 = 0.39011 μM SANGER
SF539 Growth Inhibition Assay IC50 = 0.39305 μM SANGER
MEG-01 Growth Inhibition Assay IC50 = 0.39549 μM SANGER
BE-13 Growth Inhibition Assay IC50 = 0.39872 μM SANGER
ES6 Growth Inhibition Assay IC50 = 0.40625 μM SANGER
SJRH30 Growth Inhibition Assay IC50 = 0.41411 μM SANGER
SK-HEP-1 Growth Inhibition Assay IC50 = 0.41493 μM SANGER
SCC-25 Growth Inhibition Assay IC50 = 0.41539 μM SANGER
SW982 Growth Inhibition Assay IC50 = 0.41743 μM SANGER
NALM-6 Growth Inhibition Assay IC50 = 0.42016 μM SANGER
NCI-H522 Growth Inhibition Assay IC50 = 0.42569 μM SANGER
PF-382 Growth Inhibition Assay IC50 = 0.42616 μM SANGER
C-33-A Growth Inhibition Assay IC50 = 0.43178 μM SANGER
GI-ME-N Growth Inhibition Assay IC50 = 0.44079 μM SANGER
RPMI-6666 Growth Inhibition Assay IC50 = 0.44505 μM SANGER
LOXIMVI Growth Inhibition Assay IC50 = 0.45232 μM SANGER
HCE-4 Growth Inhibition Assay IC50 = 0.45316 μM SANGER
DEL Growth Inhibition Assay IC50 = 0.47988 μM SANGER
NCI-H1650 Growth Inhibition Assay IC50 = 0.49938 μM SANGER
HCC1395 Growth Inhibition Assay IC50 = 0.50094 μM SANGER
AGS Growth Inhibition Assay IC50 = 0.50253 μM SANGER
NCI-H1651 Growth Inhibition Assay IC50 = 0.5053 μM SANGER
ES5 Growth Inhibition Assay IC50 = 0.50539 μM SANGER
NCI-H2122 Growth Inhibition Assay IC50 = 0.50953 μM SANGER
BC-3 Growth Inhibition Assay IC50 = 0.521 μM SANGER
RKO Growth Inhibition Assay IC50 = 0.52424 μM SANGER
MHH-CALL-2 Growth Inhibition Assay IC50 = 0.53464 μM SANGER
HT-29 Growth Inhibition Assay IC50 = 0.5355 μM SANGER
SW48 Growth Inhibition Assay IC50 = 0.54612 μM SANGER
GOTO Growth Inhibition Assay IC50 = 0.54993 μM SANGER
HD-MY-Z Growth Inhibition Assay IC50 = 0.5602 μM SANGER
HOS Growth Inhibition Assay IC50 = 0.56023 μM SANGER
EFO-27 Growth Inhibition Assay IC50 = 0.57104 μM SANGER
JVM-2 Growth Inhibition Assay IC50 = 0.57224 μM SANGER
SIG-M5 Growth Inhibition Assay IC50 = 0.58605 μM SANGER
HCC1569 Growth Inhibition Assay IC50 = 0.60449 μM SANGER
A101D Growth Inhibition Assay IC50 = 0.61972 μM SANGER
CAKI-1 Growth Inhibition Assay IC50 = 0.62043 μM SANGER
SBC-5 Growth Inhibition Assay IC50 = 0.62355 μM SANGER
RPMI-2650 Growth Inhibition Assay IC50 = 0.63315 μM SANGER
QIMR-WIL Growth Inhibition Assay IC50 = 0.63656 μM SANGER
NCI-H64 Growth Inhibition Assay IC50 = 0.64101 μM SANGER
NCI-SNU-5 Growth Inhibition Assay IC50 = 0.64336 μM SANGER
LXF-289 Growth Inhibition Assay IC50 = 0.64425 μM SANGER
HSC-3 Growth Inhibition Assay IC50 = 0.68829 μM SANGER
EB2 Growth Inhibition Assay IC50 = 0.69103 μM SANGER
J-RT3-T3-5 Growth Inhibition Assay IC50 = 0.71228 μM SANGER
KYSE-270 Growth Inhibition Assay IC50 = 0.7169 μM SANGER
A3-KAW Growth Inhibition Assay IC50 = 0.71692 μM SANGER
TE-12 Growth Inhibition Assay IC50 = 0.71885 μM SANGER
MDA-MB-361 Growth Inhibition Assay IC50 = 0.71909 μM SANGER
T-24 Growth Inhibition Assay IC50 = 0.71991 μM SANGER
CHL-1 Growth Inhibition Assay IC50 = 0.73154 μM SANGER
LB2241-RCC Growth Inhibition Assay IC50 = 0.73825 μM SANGER
NCI-H1437 Growth Inhibition Assay IC50 = 0.74272 μM SANGER
Ca9-22 Growth Inhibition Assay IC50 = 0.74583 μM SANGER
EGI-1 Growth Inhibition Assay IC50 = 0.77232 μM SANGER
J82 Growth Inhibition Assay IC50 = 0.77431 μM SANGER
TE-10 Growth Inhibition Assay IC50 = 0.78312 μM SANGER
Ca-Ski Growth Inhibition Assay IC50 = 0.79823 μM SANGER
NCI-H292 Growth Inhibition Assay IC50 = 0.80316 μM SANGER
8305C Growth Inhibition Assay IC50 = 0.80431 μM SANGER
A2058 Growth Inhibition Assay IC50 = 0.80768 μM SANGER
ACN Growth Inhibition Assay IC50 = 0.80834 μM SANGER
DU-145 Growth Inhibition Assay IC50 = 0.82255 μM SANGER
SNG-M Growth Inhibition Assay IC50 = 0.83083 μM SANGER
OAW-42 Growth Inhibition Assay IC50 = 0.83182 μM SANGER
MEL-HO Growth Inhibition Assay IC50 = 0.85021 μM SANGER
ONS-76 Growth Inhibition Assay IC50 = 0.85391 μM SANGER
BV-173 Growth Inhibition Assay IC50 = 0.85487 μM SANGER
SNU-423 Growth Inhibition Assay IC50 = 0.86739 μM SANGER
MLMA Growth Inhibition Assay IC50 = 0.87048 μM SANGER
A388 Growth Inhibition Assay IC50 = 0.87718 μM SANGER
NB69 Growth Inhibition Assay IC50 = 0.92254 μM SANGER
SNU-387 Growth Inhibition Assay IC50 = 0.92472 μM SANGER
U031 Growth Inhibition Assay IC50 = 0.93436 μM SANGER
NCI-H2228 Growth Inhibition Assay IC50 = 0.95465 μM SANGER
UM-UC-3 Growth Inhibition Assay IC50 = 0.95561 μM SANGER
ALL-PO Growth Inhibition Assay IC50 = 0.98627 μM SANGER
HC-1 Growth Inhibition Assay IC50 = 0.99291 μM SANGER
SK-LU-1 Growth Inhibition Assay IC50 = 0.99868 μM SANGER
TK10 Growth Inhibition Assay IC50 = 0.99868 μM SANGER
8505C Growth Inhibition Assay IC50 = 1.03998 μM SANGER
NCCIT Growth Inhibition Assay IC50 = 1.06873 μM SANGER
NCI-H510A Growth Inhibition Assay IC50 = 1.09156 μM SANGER
NUGC-3 Growth Inhibition Assay IC50 = 1.13021 μM SANGER
DJM-1 Growth Inhibition Assay IC50 = 1.13172 μM SANGER
MCF7 Growth Inhibition Assay IC50 = 1.16584 μM SANGER
GI-1 Growth Inhibition Assay IC50 = 1.20001 μM SANGER
NCI-H747 Growth Inhibition Assay IC50 = 1.21374 μM SANGER
RPMI-7951 Growth Inhibition Assay IC50 = 1.24443 μM SANGER
RCM-1 Growth Inhibition Assay IC50 = 1.26178 μM SANGER
CHP-126 Growth Inhibition Assay IC50 = 1.26806 μM SANGER
DU-4475 Growth Inhibition Assay IC50 = 1.26828 μM SANGER
NCI-H526 Growth Inhibition Assay IC50 = 1.27996 μM SANGER
FTC-133 Growth Inhibition Assay IC50 = 1.29359 μM SANGER
NOS-1 Growth Inhibition Assay IC50 = 1.30544 μM SANGER
HuP-T4 Growth Inhibition Assay IC50 = 1.3128 μM SANGER
YT Growth Inhibition Assay IC50 = 1.31567 μM SANGER
SF268 Growth Inhibition Assay IC50 = 1.31797 μM SANGER
KYSE-70 Growth Inhibition Assay IC50 = 1.37884 μM SANGER
ES8 Growth Inhibition Assay IC50 = 1.39853 μM SANGER
MC-CAR Growth Inhibition Assay IC50 = 1.39929 μM SANGER
SW626 Growth Inhibition Assay IC50 = 1.40825 μM SANGER
BCPAP Growth Inhibition Assay IC50 = 1.43514 μM SANGER
MRK-nu-1 Growth Inhibition Assay IC50 = 1.45252 μM SANGER
SK-PN-DW Growth Inhibition Assay IC50 = 1.45278 μM SANGER
8-MG-BA Growth Inhibition Assay IC50 = 1.47953 μM SANGER
MG-63 Growth Inhibition Assay IC50 = 1.48966 μM SANGER
LCLC-97TM1 Growth Inhibition Assay IC50 = 1.49578 μM SANGER
MDA-MB-175-VII Growth Inhibition Assay IC50 = 1.51005 μM SANGER
697 Growth Inhibition Assay IC50 = 1.57595 μM SANGER
SW837 Growth Inhibition Assay IC50 = 1.60642 μM SANGER
ES3 Growth Inhibition Assay IC50 = 1.60859 μM SANGER
EHEB Growth Inhibition Assay IC50 = 1.60861 μM SANGER
SNB75 Growth Inhibition Assay IC50 = 1.60892 μM SANGER
Daudi Growth Inhibition Assay IC50 = 1.67096 μM SANGER
MES-SA Growth Inhibition Assay IC50 = 1.67344 μM SANGER
LK-2 Growth Inhibition Assay IC50 = 1.68921 μM SANGER
647-V Growth Inhibition Assay IC50 = 1.73341 μM SANGER
MOLT-4 Growth Inhibition Assay IC50 = 1.77334 μM SANGER
OCUB-M Growth Inhibition Assay IC50 = 1.81357 μM SANGER
EW-1 Growth Inhibition Assay IC50 = 1.81784 μM SANGER
BHY Growth Inhibition Assay IC50 = 1.82747 μM SANGER
Raji Growth Inhibition Assay IC50 = 1.84743 μM SANGER
KYSE-510 Growth Inhibition Assay IC50 = 1.85749 μM SANGER
KYSE-450 Growth Inhibition Assay IC50 = 1.93424 μM SANGER
SW962 Growth Inhibition Assay IC50 = 1.95452 μM SANGER
MHH-NB-11 Growth Inhibition Assay IC50 = 2.00542 μM SANGER
PA-1 Growth Inhibition Assay IC50 = 2.01527 μM SANGER
KURAMOCHI Growth Inhibition Assay IC50 = 2.03812 μM SANGER
SU-DHL-1 Growth Inhibition Assay IC50 = 2.04945 μM SANGER
AU565 Growth Inhibition Assay IC50 = 2.05402 μM SANGER
MC116 Growth Inhibition Assay IC50 = 2.11053 μM SANGER
A431 Growth Inhibition Assay IC50 = 2.11197 μM SANGER
OE19 Growth Inhibition Assay IC50 = 2.14352 μM SANGER
CAL-33 Growth Inhibition Assay IC50 = 2.14602 μM SANGER
KP-4 Growth Inhibition Assay IC50 = 2.17066 μM SANGER
SJSA-1 Growth Inhibition Assay IC50 = 2.18726 μM SANGER
COLO-800 Growth Inhibition Assay IC50 = 2.20714 μM SANGER
NH-12 Growth Inhibition Assay IC50 = 2.20811 μM SANGER
IPC-298 Growth Inhibition Assay IC50 = 2.21227 μM SANGER
OCI-AML2 Growth Inhibition Assay IC50 = 2.25537 μM SANGER
HH Growth Inhibition Assay IC50 = 2.28651 μM SANGER
BFTC-905 Growth Inhibition Assay IC50 = 2.31888 μM SANGER
RT-112 Growth Inhibition Assay IC50 = 2.31957 μM SANGER
SNU-C2B Growth Inhibition Assay IC50 = 2.32484 μM SANGER
IGR-1 Growth Inhibition Assay IC50 = 2.34633 μM SANGER
NCI-H2087 Growth Inhibition Assay IC50 = 2.34738 μM SANGER
EoL-1-cell Growth Inhibition Assay IC50 = 2.41593 μM SANGER
SCC-4 Growth Inhibition Assay IC50 = 2.4302 μM SANGER
HuH-7 Growth Inhibition Assay IC50 = 2.43456 μM SANGER
HSC-2 Growth Inhibition Assay IC50 = 2.46672 μM SANGER
NCI-H23 Growth Inhibition Assay IC50 = 2.46688 μM SANGER
AN3-CA Growth Inhibition Assay IC50 = 2.55034 μM SANGER
NCI-H2009 Growth Inhibition Assay IC50 = 2.56438 μM SANGER
NCI-H1792 Growth Inhibition Assay IC50 = 2.56683 μM SANGER
RVH-421 Growth Inhibition Assay IC50 = 2.57186 μM SANGER
SK-LMS-1 Growth Inhibition Assay IC50 = 2.65761 μM SANGER
COLO-679 Growth Inhibition Assay IC50 = 2.66172 μM SANGER
VMRC-RCZ Growth Inhibition Assay IC50 = 2.68962 μM SANGER
NCI-H28 Growth Inhibition Assay IC50 = 2.73884 μM SANGER
HT-1197 Growth Inhibition Assay IC50 = 2.74098 μM SANGER
OE33 Growth Inhibition Assay IC50 = 2.75256 μM SANGER
BT-20 Growth Inhibition Assay IC50 = 2.767 μM SANGER
NCI-H661 Growth Inhibition Assay IC50 = 2.78722 μM SANGER
HCE-T Growth Inhibition Assay IC50 = 2.83188 μM SANGER
HGC-27 Growth Inhibition Assay IC50 = 2.83636 μM SANGER
NCI-SNU-1 Growth Inhibition Assay IC50 = 2.84084 μM SANGER
A253 Growth Inhibition Assay IC50 = 2.85522 μM SANGER
HCT-116 Growth Inhibition Assay IC50 = 2.88305 μM SANGER
CAPAN-1 Growth Inhibition Assay IC50 = 2.92149 μM SANGER
MZ2-MEL Growth Inhibition Assay IC50 = 2.94674 μM SANGER
NCI-N87 Growth Inhibition Assay IC50 = 2.96422 μM SANGER
NCI-H2052 Growth Inhibition Assay IC50 = 2.96513 μM SANGER
DMS-273 Growth Inhibition Assay IC50 = 2.98076 μM SANGER
MC-IXC Growth Inhibition Assay IC50 = 2.99693 μM SANGER
OS-RC-2 Growth Inhibition Assay IC50 = 3.02325 μM SANGER
TYK-nu Growth Inhibition Assay IC50 = 3.03067 μM SANGER
EW-7 Growth Inhibition Assay IC50 = 3.05866 μM SANGER
SK-MES-1 Growth Inhibition Assay IC50 = 3.07459 μM SANGER
SF126 Growth Inhibition Assay IC50 = 3.08914 μM SANGER
LB647-SCLC Growth Inhibition Assay IC50 = 3.14297 μM SANGER
SCC-3 Growth Inhibition Assay IC50 = 3.20606 μM SANGER
TE-15 Growth Inhibition Assay IC50 = 3.22315 μM SANGER
M14 Growth Inhibition Assay IC50 = 3.22456 μM SANGER
COLO-205 Growth Inhibition Assay IC50 = 3.24454 μM SANGER
YKG-1 Growth Inhibition Assay IC50 = 3.25583 μM SANGER
SAS Growth Inhibition Assay IC50 = 3.26145 μM SANGER
G-401 Growth Inhibition Assay IC50 = 3.2899 μM SANGER
CAL-62 Growth Inhibition Assay IC50 = 3.34045 μM SANGER
HCC1599 Growth Inhibition Assay IC50 = 3.36875 μM SANGER
JiyoyeP-2003 Growth Inhibition Assay IC50 = 3.38494 μM SANGER
IA-LM Growth Inhibition Assay IC50 = 3.4017 μM SANGER
COLO-320-HSR Growth Inhibition Assay IC50 = 3.43354 μM SANGER
SW872 Growth Inhibition Assay IC50 = 3.45241 μM SANGER
SW620 Growth Inhibition Assay IC50 = 3.55738 μM SANGER
M059J Growth Inhibition Assay IC50 = 3.76703 μM SANGER
KYSE-180 Growth Inhibition Assay IC50 = 3.79836 μM SANGER
BxPC-3 Growth Inhibition Assay IC50 = 3.80576 μM SANGER
D-283MED Growth Inhibition Assay IC50 = 3.81218 μM SANGER
KYSE-140 Growth Inhibition Assay IC50 = 3.89603 μM SANGER
BC-1 Growth Inhibition Assay IC50 = 3.91812 μM SANGER
HLE Growth Inhibition Assay IC50 = 3.99693 μM SANGER
MN-60 Growth Inhibition Assay IC50 = 4.05162 μM SANGER
NCI-H1304 Growth Inhibition Assay IC50 = 4.1047 μM SANGER
IM-9 Growth Inhibition Assay IC50 = 4.13195 μM SANGER
NOMO-1 Growth Inhibition Assay IC50 = 4.20151 μM SANGER
SW1990 Growth Inhibition Assay IC50 = 4.24402 μM SANGER
NCI-H2405 Growth Inhibition Assay IC50 = 4.27798 μM SANGER
LAMA-84 Growth Inhibition Assay IC50 = 4.28656 μM SANGER
CGTH-W-1 Growth Inhibition Assay IC50 = 4.30277 μM SANGER
EFO-21 Growth Inhibition Assay IC50 = 4.33027 μM SANGER
U251 Growth Inhibition Assay IC50 = 4.36314 μM SANGER
OVCAR-4 Growth Inhibition Assay IC50 = 4.41035 μM SANGER
HO-1-N-1 Growth Inhibition Assay IC50 = 4.41781 μM SANGER
CaR-1 Growth Inhibition Assay IC50 = 4.44726 μM SANGER
CCF-STTG1 Growth Inhibition Assay IC50 = 4.56209 μM SANGER
MONO-MAC-6 Growth Inhibition Assay IC50 = 4.59384 μM SANGER
CAL-148 Growth Inhibition Assay IC50 = 4.60119 μM SANGER
OVCAR-5 Growth Inhibition Assay IC50 = 4.74899 μM SANGER
NCI-H460 Growth Inhibition Assay IC50 = 4.75506 μM SANGER
HuP-T3 Growth Inhibition Assay IC50 = 4.79184 μM SANGER
SK-OV-3 Growth Inhibition Assay IC50 = 4.88426 μM SANGER
VM-CUB-1 Growth Inhibition Assay IC50 = 4.91668 μM SANGER
CTV-1 Growth Inhibition Assay IC50 = 4.92002 μM SANGER
AM-38 Growth Inhibition Assay IC50 = 4.94112 μM SANGER
GCT Growth Inhibition Assay IC50 = 4.99065 μM SANGER
NCI-H2347 Growth Inhibition Assay IC50 = 5.11661 μM SANGER
DB Growth Inhibition Assay IC50 = 5.11905 μM SANGER
FADU Growth Inhibition Assay IC50 = 5.13773 μM SANGER
Calu-1 Growth Inhibition Assay IC50 = 5.13779 μM SANGER
NCI-H2030 Growth Inhibition Assay IC50 = 5.21763 μM SANGER
DOHH-2 Growth Inhibition Assay IC50 = 5.28851 μM SANGER
NCI-H1770 Growth Inhibition Assay IC50 = 5.29092 μM SANGER
P12-ICHIKAWA Growth Inhibition Assay IC50 = 5.54575 μM SANGER
HT Growth Inhibition Assay IC50 = 5.55505 μM SANGER
CAL-120 Growth Inhibition Assay IC50 = 5.56142 μM SANGER
DBTRG-05MG Growth Inhibition Assay IC50 = 5.67305 μM SANGER
COLO-680N Growth Inhibition Assay IC50 = 5.7583 μM SANGER
HT-3 Growth Inhibition Assay IC50 = 5.77714 μM SANGER
NY Growth Inhibition Assay IC50 = 5.91176 μM SANGER
NCI-H838 Growth Inhibition Assay IC50 = 5.94757 μM SANGER
NCI-H1618 Growth Inhibition Assay IC50 = 5.98557 μM SANGER
TE-11 Growth Inhibition Assay IC50 = 6.08459 μM SANGER
Calu-3 Growth Inhibition Assay IC50 = 6.19074 μM SANGER
ST486 Growth Inhibition Assay IC50 = 6.39405 μM SANGER
EW-11 Growth Inhibition Assay IC50 = 6.41293 μM SANGER
TE-1 Growth Inhibition Assay IC50 = 6.42507 μM SANGER
NB5 Growth Inhibition Assay IC50 = 6.72078 μM SANGER
DMS-114 Growth Inhibition Assay IC50 = 6.78617 μM SANGER
KYSE-520 Growth Inhibition Assay IC50 = 6.78887 μM SANGER
SIMA Growth Inhibition Assay IC50 = 6.93011 μM SANGER
KM-H2 Growth Inhibition Assay IC50 = 6.96614 μM SANGER
WM-115 Growth Inhibition Assay IC50 = 7.09344 μM SANGER
P30-OHK Growth Inhibition Assay IC50 = 7.09585 μM SANGER
22RV1 Growth Inhibition Assay IC50 = 7.32932 μM SANGER
BHT-101 Growth Inhibition Assay IC50 = 7.34054 μM SANGER
COR-L105 Growth Inhibition Assay IC50 = 7.36534 μM SANGER
Calu-6 Growth Inhibition Assay IC50 = 7.67159 μM SANGER
C8166 Growth Inhibition Assay IC50 = 7.77036 μM SANGER
SH-4 Growth Inhibition Assay IC50 = 7.84755 μM SANGER
RPMI-8866 Growth Inhibition Assay IC50 = 7.9095 μM SANGER
TE-5 Growth Inhibition Assay IC50 = 7.96408 μM SANGER
CAL-27 Growth Inhibition Assay IC50 = 8.07296 μM SANGER
KYSE-410 Growth Inhibition Assay IC50 = 8.1465 μM SANGER
NCI-H1355 Growth Inhibition Assay IC50 = 8.20414 μM SANGER
LB831-BLC Growth Inhibition Assay IC50 = 8.38272 μM SANGER
SK-MEL-2 Growth Inhibition Assay IC50 = 8.48548 μM SANGER
JEG-3 Growth Inhibition Assay IC50 = 8.5506 μM SANGER
NCI-H441 Growth Inhibition Assay IC50 = 9.04985 μM SANGER
KM12 Growth Inhibition Assay IC50 = 9.18802 μM SANGER
OAW-28 Growth Inhibition Assay IC50 = 9.20646 μM SANGER
HOP-92 Growth Inhibition Assay IC50 = 9.26 μM SANGER
HT-1376 Growth Inhibition Assay IC50 = 9.73755 μM SANGER
Ramos-2G6-4C10 Growth Inhibition Assay IC50 = 9.88105 μM SANGER
NCI-H727 Growth Inhibition Assay IC50 = 10.3102 μM SANGER
A673 Growth Inhibition Assay IC50 = 10.4566 μM SANGER
A704 Growth Inhibition Assay IC50 = 10.6436 μM SANGER
HEL Growth Inhibition Assay IC50 = 10.8362 μM SANGER
HuCCT1 Growth Inhibition Assay IC50 = 10.9343 μM SANGER
U-87-MG Growth Inhibition Assay IC50 = 11.0572 μM SANGER
LC4-1 Growth Inhibition Assay IC50 = 11.1604 μM SANGER
SW756 Growth Inhibition Assay IC50 = 11.3757 μM SANGER
NCI-H1882 Growth Inhibition Assay IC50 = 11.455 μM SANGER
NB1 Growth Inhibition Assay IC50 = 11.5965 μM SANGER
KALS-1 Growth Inhibition Assay IC50 = 11.7421 μM SANGER
OMC-1 Growth Inhibition Assay IC50 = 11.8941 μM SANGER
Detroit562 Growth Inhibition Assay IC50 = 11.931 μM SANGER
PANC-08-13 Growth Inhibition Assay IC50 = 12.0521 μM SANGER
TE-6 Growth Inhibition Assay IC50 = 12.3857 μM SANGER
GCIY Growth Inhibition Assay IC50 = 12.7546 μM SANGER
U-698-M Growth Inhibition Assay IC50 = 13.0065 μM SANGER
PC-3 Growth Inhibition Assay IC50 = 13.3146 μM SANGER
T84 Growth Inhibition Assay IC50 = 13.4592 μM SANGER
NCI-H596 Growth Inhibition Assay IC50 = 13.5755 μM SANGER
D-392MG Growth Inhibition Assay IC50 = 13.5799 μM SANGER
NB10 Growth Inhibition Assay IC50 = 13.8464 μM SANGER
BL-41 Growth Inhibition Assay IC50 = 14.1975 μM SANGER
HDLM-2 Growth Inhibition Assay IC50 = 14.3177 μM SANGER
LAN-6 Growth Inhibition Assay IC50 = 14.6341 μM SANGER
CMK Growth Inhibition Assay IC50 = 14.7963 μM SANGER
MDA-MB-453 Growth Inhibition Assay IC50 = 15.4155 μM SANGER
GP5d Growth Inhibition Assay IC50 = 15.636 μM SANGER
TCCSUP Growth Inhibition Assay IC50 = 15.9419 μM SANGER
NCI-H520 Growth Inhibition Assay IC50 = 16.0521 μM SANGER
ChaGo-K-1 Growth Inhibition Assay IC50 = 16.3642 μM SANGER
COLO-741 Growth Inhibition Assay IC50 = 16.4227 μM SANGER
NCI-H1693 Growth Inhibition Assay IC50 = 16.565 μM SANGER
DG-75 Growth Inhibition Assay IC50 = 16.9142 μM SANGER
CAMA-1 Growth Inhibition Assay IC50 = 17.5247 μM SANGER
LNCaP-Clone-FGC Growth Inhibition Assay IC50 = 18.3155 μM SANGER
EW-3 Growth Inhibition Assay IC50 = 18.5014 μM SANGER
TUR Growth Inhibition Assay IC50 = 18.8518 μM SANGER
NCI-H446 Growth Inhibition Assay IC50 = 18.8813 μM SANGER
ATN-1 Growth Inhibition Assay IC50 = 18.9202 μM SANGER
LU-65 Growth Inhibition Assay IC50 = 19.4673 μM SANGER
ABC-1 Growth Inhibition Assay IC50 = 19.6679 μM SANGER
NCI-H1648 Growth Inhibition Assay IC50 = 20.3205 μM SANGER
Caov-3 Growth Inhibition Assay IC50 = 20.4613 μM SANGER
NCI-H1563 Growth Inhibition Assay IC50 = 20.6061 μM SANGER
KLE Growth Inhibition Assay IC50 = 21.24 μM SANGER
MMAC-SF Growth Inhibition Assay IC50 = 21.327 μM SANGER
BB65-RCC Growth Inhibition Assay IC50 = 21.4262 μM SANGER
EB-3 Growth Inhibition Assay IC50 = 21.8331 μM SANGER
SK-MEL-3 Growth Inhibition Assay IC50 = 22.1755 μM SANGER
NCI-H2196 Growth Inhibition Assay IC50 = 22.8494 μM SANGER
GR-ST Growth Inhibition Assay IC50 = 23.0977 μM SANGER
SK-MM-2 Growth Inhibition Assay IC50 = 23.239 μM SANGER
SK-MEL-24 Growth Inhibition Assay IC50 = 23.2952 μM SANGER
LS-123 Growth Inhibition Assay IC50 = 23.4283 μM SANGER
SW1463 Growth Inhibition Assay IC50 = 23.4421 μM SANGER
L-540 Growth Inhibition Assay IC50 = 23.5493 μM SANGER
Capan-2 Growth Inhibition Assay IC50 = 24.2155 μM SANGER
NCI-H1838 Growth Inhibition Assay IC50 = 24.5232 μM SANGER
TE-441-T Growth Inhibition Assay IC50 = 24.6153 μM SANGER
A4-Fuk Growth Inhibition Assay IC50 = 25.288 μM SANGER
COR-L279 Growth Inhibition Assay IC50 = 25.3526 μM SANGER
KE-37 Growth Inhibition Assay IC50 = 25.9179 μM SANGER
NCI-H1755 Growth Inhibition Assay IC50 = 26.001 μM SANGER
KP-N-YN Growth Inhibition Assay IC50 = 26.337 μM SANGER
COLO-792 Growth Inhibition Assay IC50 = 26.4052 μM SANGER
Becker Growth Inhibition Assay IC50 = 26.9253 μM SANGER
no-10 Growth Inhibition Assay IC50 = 27.0943 μM SANGER
NCI-H1793 Growth Inhibition Assay IC50 = 27.172 μM SANGER
HCC1143 Growth Inhibition Assay IC50 = 27.1918 μM SANGER
KARPAS-299 Growth Inhibition Assay IC50 = 27.2024 μM SANGER
HEC-1 Growth Inhibition Assay IC50 = 27.3627 μM SANGER
SCC-15 Growth Inhibition Assay IC50 = 27.6315 μM SANGER
LS-513 Growth Inhibition Assay IC50 = 28.9662 μM SANGER
HN Growth Inhibition Assay IC50 = 29.1374 μM SANGER
MOLT-16 Growth Inhibition Assay IC50 = 29.5165 μM SANGER
KP-N-YS Growth Inhibition Assay IC50 = 30.2856 μM SANGER
NCI-H1417 Growth Inhibition Assay IC50 = 30.3916 μM SANGER
RPMI-8402 Growth Inhibition Assay IC50 = 30.7398 μM SANGER
WSU-NHL Growth Inhibition Assay IC50 = 31.634 μM SANGER
SK-NEP-1 Growth Inhibition Assay IC50 = 31.88 μM SANGER
HCC1187 Growth Inhibition Assay IC50 = 32.9082 μM SANGER
PFSK-1 Growth Inhibition Assay IC50 = 33.4435 μM SANGER
TE-9 Growth Inhibition Assay IC50 = 33.9766 μM SANGER
NCI-H209 Growth Inhibition Assay IC50 = 34.3161 μM SANGER
HL-60 Growth Inhibition Assay IC50 = 35.2849 μM SANGER
LS-1034 Growth Inhibition Assay IC50 = 35.3757 μM SANGER
NCI-H2141 Growth Inhibition Assay IC50 = 36.1155 μM SANGER
COLO-678 Growth Inhibition Assay IC50 = 36.2389 μM SANGER
NB13 Growth Inhibition Assay IC50 = 36.744 μM SANGER
COLO-829 Growth Inhibition Assay IC50 = 36.9718 μM SANGER
BB49-HNC Growth Inhibition Assay IC50 = 38.7612 μM SANGER
NCI-H1623 Growth Inhibition Assay IC50 = 39.0477 μM SANGER
A172 Growth Inhibition Assay IC50 = 39.7268 μM SANGER
MPP-89 Growth Inhibition Assay IC50 = 39.8805 μM SANGER
ME-180 Growth Inhibition Assay IC50 = 40.8628 μM SANGER
LU-165 Growth Inhibition Assay IC50 = 41.7959 μM SANGER
LU-134-A Growth Inhibition Assay IC50 = 41.8216 μM SANGER
HCC2218 Growth Inhibition Assay IC50 = 41.8898 μM SANGER
NCI-H1694 Growth Inhibition Assay IC50 = 43.8822 μM SANGER
BEN Growth Inhibition Assay IC50 = 46.0431 μM SANGER
RERF-LC-MS Growth Inhibition Assay IC50 = 48.6853 μM SANGER
LC-1F Growth Inhibition Assay IC50 = 49.4076 μM SANGER
L-428 Growth Inhibition Assay IC50 = 52.3358 μM SANGER
CPC-N Growth Inhibition Assay IC50 = 52.489 μM SANGER
COLO-824 Growth Inhibition Assay IC50 = 53.329 μM SANGER
IST-SL1 Growth Inhibition Assay IC50 = 54.5851 μM SANGER
NCI-H810 Growth Inhibition Assay IC50 = 55.1277 μM SANGER
LB373-MEL-D Growth Inhibition Assay IC50 = 56.4075 μM SANGER
ECC4 Growth Inhibition Assay IC50 = 56.7007 μM SANGER
TT Growth Inhibition Assay IC50 = 59.1501 μM SANGER
D-542MG Growth Inhibition Assay IC50 = 60.2794 μM SANGER
T98G Growth Inhibition Assay IC50 = 63.7348 μM SANGER
U-118-MG Growth Inhibition Assay IC50 = 65.6647 μM SANGER
TGW Growth Inhibition Assay IC50 = 65.7504 μM SANGER
MKN7 Growth Inhibition Assay IC50 = 66.5296 μM SANGER
MDA-MB-415 Growth Inhibition Assay IC50 = 67.3338 μM SANGER
SNU-475 Growth Inhibition Assay IC50 = 67.5008 μM SANGER
MDA-MB-468 Growth Inhibition Assay IC50 = 67.5522 μM SANGER
KU812 Growth Inhibition Assay IC50 = 67.9601 μM SANGER
RCC10RGB Growth Inhibition Assay IC50 = 70.5644 μM SANGER
K5 Growth Inhibition Assay IC50 = 72.3646 μM SANGER
NCI-H1155 Growth Inhibition Assay IC50 = 73.2129 μM SANGER
COR-L88 Growth Inhibition Assay IC50 = 73.4243 μM SANGER
TGBC1TKB Growth Inhibition Assay IC50 = 74.14 μM SANGER
NCI-H748 Growth Inhibition Assay IC50 = 75.1768 μM SANGER
EW-18 Growth Inhibition Assay IC50 = 75.8498 μM SANGER
NCI-H226 Growth Inhibition Assay IC50 = 77.3602 μM SANGER
HTC-C3 Growth Inhibition Assay IC50 = 77.8428 μM SANGER
CAS-1 Growth Inhibition Assay IC50 = 81.0296 μM SANGER
SNU-C1 Growth Inhibition Assay IC50 = 81.9941 μM SANGER
NB12 Growth Inhibition Assay IC50 = 82.3997 μM SANGER
AsPC-1 Growth Inhibition Assay IC50 = 82.5028 μM SANGER
HCC1954 Growth Inhibition Assay IC50 = 84.163 μM SANGER
EM-2 Growth Inhibition Assay IC50 = 84.7528 μM SANGER
CA46 Growth Inhibition Assay IC50 = 84.8498 μM SANGER
no-11 Growth Inhibition Assay IC50 = 85.5708 μM SANGER
DK-MG Growth Inhibition Assay IC50 = 85.7672 μM SANGER
HuO-3N1 Growth Inhibition Assay IC50 = 87.8298 μM SANGER
S-117 Growth Inhibition Assay IC50 = 90.2444 μM SANGER
C2BBe1 Growth Inhibition Assay IC50 = 91.8016 μM SANGER
THP-1 Growth Inhibition Assay IC50 = 92.4868 μM SANGER
HCC2157 Growth Inhibition Assay IC50 = 93.3592 μM SANGER
EW-24 Growth Inhibition Assay IC50 = 95.3316 μM SANGER
UACC-812 Growth Inhibition Assay IC50 = 99.5951 μM SANGER
NCI-H720 Growth Inhibition Assay IC50 = 103.351 μM SANGER
NCI-H69 Growth Inhibition Assay IC50 = 103.909 μM SANGER
OPM-2 Growth Inhibition Assay IC50 = 104.066 μM SANGER
RD Growth Inhibition Assay IC50 = 105.698 μM SANGER
NCI-H1581 Growth Inhibition Assay IC50 = 110.224 μM SANGER
OVCAR-3 Growth Inhibition Assay IC50 = 123.332 μM SANGER
HCC70 Growth Inhibition Assay IC50 = 125.868 μM SANGER
GAK Growth Inhibition Assay IC50 = 126.132 μM SANGER
K-562 Growth Inhibition Assay IC50 = 126.227 μM SANGER
UACC-893 Growth Inhibition Assay IC50 = 129.777 μM SANGER
SKG-IIIa Growth Inhibition Assay IC50 = 136.469 μM SANGER
SHP-77 Growth Inhibition Assay IC50 = 142.135 μM SANGER
D-263MG Growth Inhibition Assay IC50 = 142.206 μM SANGER
Mewo Growth Inhibition Assay IC50 = 147.962 μM SANGER
MSTO-211H Growth Inhibition Assay IC50 = 149.459 μM SANGER
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生物活性

產(chǎn)品描述 Bleomycin Sulfate硫酸博來霉素是一種糖肽類抗生素，一種DNA 合成抑制劑，也是一種鱗狀細(xì)胞癌(SCC)抗癌劑，在UT-SCC-19A細(xì)胞中IC50為4 nM。Bleomycin sulfate是一種DNA 合成抑制劑。
體外研究(In Vitro)
體外研究活性

UT-SCC-12A和 UT-SCC-12B均對(duì)Bleomycin sulfate耐藥，IC50分別為14.2 nM 和13 nM。[1]肺泡巨噬細(xì)胞與0.01 μg/mL到1μg /mL Bleomycin sulfate培養(yǎng)18小時(shí)顯著比巨噬細(xì)胞單獨(dú)培養(yǎng)分泌更多的成纖維細(xì)胞生長(zhǎng)因子。Bleomycin sulfate刺激的巨噬細(xì)胞持續(xù)產(chǎn)生大量成纖維細(xì)胞生長(zhǎng)因子，即使在移去Bleomycin sulfate，用新鮮培養(yǎng)基(不含Bleomycin sulfate)取代之后，該作用依然存在。Bleomycin sulfate刺激肺泡巨噬細(xì)胞導(dǎo)致的纖維素生長(zhǎng)因子分泌被環(huán)己酰亞胺，和5-脂氧合酶抑制劑NDGA(去甲二氫愈創(chuàng)木酸)和BW755c抑制，表明其不僅需要蛋白質(zhì)合成，也需要花生四烯酸代謝的5-脂氧合酶途徑活性完全表達(dá)。[2] Bleomycin sulfate (400 µg/mL)培養(yǎng)24小時(shí)，降低NTera-2細(xì)胞的活性，增加caspase-3，-8和-9的活性，增加Bax和細(xì)胞質(zhì)細(xì)胞色素C水平，并降低Bcl-2水平。[3]對(duì)于不穩(wěn)定性畸變，Bleomycin sulfate對(duì)ADIPO-P2細(xì)胞的致染色體斷裂作用在處理后至少持續(xù)10天。此外，暴露于Bleomycin sulfate的細(xì)胞處理10天后，端粒融合體的外觀表明Bleomycin sulfate能夠誘導(dǎo)延遲的端粒失穩(wěn)。[4]
細(xì)胞實(shí)驗(yàn) 細(xì)胞系 ADIPO-P2 細(xì)胞
濃度 2.5 μg/mL
孵育時(shí)間 30分鐘
方法

ADIPO-P2細(xì)胞在D-MEM高葡萄糖培養(yǎng)基中生長(zhǎng)，用20%胎牛血清，青霉素(100 U/mL) 和鏈霉素 (100 μg/mL)增補(bǔ)，在37 °C 和5% CO2大氣環(huán)境中培養(yǎng)。細(xì)胞在包含1.5×105 cells/mL的TC25 Corning培養(yǎng)瓶中單層培養(yǎng)。對(duì)于每個(gè)實(shí)驗(yàn)，建立兩個(gè)培養(yǎng)瓶，一個(gè)用于對(duì)照組，一個(gè)用于處理培養(yǎng)。在對(duì)數(shù)生長(zhǎng)期，ADIPO-P2細(xì)胞用2.5 μg/mL Bleomycin sulfate以30分鐘脈沖處理。建立平行對(duì)照組，不暴露于Bleomycin sulfate。暴露時(shí)間和Bleomycin sulfate濃度根據(jù)先前實(shí)驗(yàn)室中進(jìn)行的Bleomycin sulfate處理哺乳動(dòng)物細(xì)胞的研究進(jìn)行選擇。Bleomycin sulfate脈沖處理結(jié)束時(shí)，細(xì)胞用Hank's平衡鹽溶液清洗兩次，并保存在新鮮培養(yǎng)基中直到采集。處理后5個(gè)傳代培養(yǎng)期間，將細(xì)胞持續(xù)保持在培養(yǎng)基中。當(dāng)培養(yǎng)基中融合(培養(yǎng)基中大約4×105 cells/mL)時(shí)，進(jìn)行傳代培養(yǎng)。為估計(jì)細(xì)胞生長(zhǎng)，傳代培養(yǎng)時(shí)，細(xì)胞通過胰蛋白酶化收集，每等份大約200 μL，用0.4%臺(tái)盼藍(lán)著色，測(cè)定活細(xì)胞數(shù)量。隨后細(xì)胞懸浮在新鮮培養(yǎng)基中，重新分配到包含1×105 cells/mL的新培養(yǎng)瓶中繼續(xù)生長(zhǎng)。將剩余的細(xì)胞丟棄或置于另外的培養(yǎng)瓶中進(jìn)行細(xì)胞遺傳學(xué)分析，這在處理結(jié)束后18小時(shí)或第10天進(jìn)行。為分析染色體突變，培養(yǎng)的最后3小時(shí)將colchicine (0.1 μg/mL)加入到細(xì)胞培養(yǎng)基。染色體的制備根據(jù)標(biāo)準(zhǔn)程序進(jìn)行。采集后，將細(xì)胞低滲震動(dòng)，固定在甲醇:乙酸(3:1)中，涂布在載玻片上，進(jìn)行PNA-FISH。進(jìn)行兩個(gè)獨(dú)立的實(shí)驗(yàn)。
實(shí)驗(yàn)圖片 檢測(cè)方法 檢測(cè)指標(biāo) 實(shí)驗(yàn)圖片 PMID
Western blot LRP6 / Wnt5AB / Dvl2 / β-catenin phospho-eIF2α / eIF2α cytochrome c Bcl-xl Bcl-2 27649046
Immunofluorescence LC3 23762310
ELISA HMGB1 23762310
體內(nèi)研究(In Vivo)
體內(nèi)研究活性

Bleomycin sulfate處理后第7天，NOX-/- 的BALf中CD45+細(xì)胞是WT的1.7倍多，其中57%為Mf，第21天，在WT中減少到67%，在NOX-/-中減少到83%。[5]
動(dòng)物實(shí)驗(yàn) Animal Models CD-1小鼠
Dosages 5 mg/kg, 2 ml/kg
Administration 鞘內(nèi)注射給藥

化學(xué)信息&溶解度

分子量 1512.62 分子式

C55H85N17O25S4
CAS號(hào) 9041-93-4 SDF Download Bleomycin sulfate SDF
Smiles CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)[O-]
儲(chǔ)存條件(自收到貨起)

體外溶解度
批次：

DMSO : 100 mg/mL ( (66.11 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請(qǐng)使用新開封DMSO)

Water : 25 mg/mL (16.52 mM)

Ethanol : Insoluble

摩爾濃度計(jì)算器

體內(nèi)溶解度
批次：

現(xiàn)配現(xiàn)用，請(qǐng)按從左到右的順序依次添加，澄清后再加入下一溶劑

 動(dòng)物體內(nèi)配方計(jì)算器

實(shí)驗(yàn)計(jì)算

摩爾濃度計(jì)算器

質(zhì)量 濃度 體積 分子量

動(dòng)物體內(nèi)配方計(jì)算器（澄清溶液）

第一步：請(qǐng)輸入基本實(shí)驗(yàn)信息（考慮到實(shí)驗(yàn)過程中的損耗，建議多配一只動(dòng)物的藥量）

mg/kg g μL 只

第二步：請(qǐng)輸入動(dòng)物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請(qǐng)聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計(jì)算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請(qǐng)先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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常見問題及建議解決方法

問題 1:
what is the ratio between bleomycin A2 and bleomycin B2 in your product?

回答：
The content of Bleomycin A2 and Bleomycin B2 is 62% and 29% respectively.

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