GSK 461364

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1688

CAS [929095-18-1]

MF C27H28F3N5O2S
MW 543.60

Purity: 99%
Optical purity: 99% ee
Soluble in DMSO

GSK 461364

Description

Potent and selective Polo-like kinase (PLK) 1 inhibitor, more selective at PLK1 (Ki: 2.2 nM) over PLK2 and PLK3.

TR Rheault et al. Heteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophene carboxamides: potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like properties. Bioorg. Med. Chem. Lett. 2010, 20(15), 4587-92.

KA Emmitte et al. Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding. Bioorg. Med. Chem. Lett. 2009, 19(6), 1694-7.

Cell Cycle Regulation Cell Signaling & Oncology EC 2.7.11.21 PLK

PLK1 inhibitor

Chemical name

(R)-5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide

Parent CAS No.

[929095-18-1]

Order

Size	Unit Price	Stock
5 mg	$115.50	In Stock
25 mg	$396.00	In Stock

Special Offers

Size	Unit Price	Stock
2 x 5 mg	$176.00	In Stock
2 x 25 mg	$594.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description	From price
1129	BI 2536	PLK1 inhibitor		$66.00
1131	GW 843682X	PLK1 and PLK3 inhibitor		$93.50
1473	BI 6727	PLK1 Inhibitor		$99.00
1530	RO 3306	CDK1 inhibitor		$88.00
1585	Nutlin-3	MDM2 inhibitor (p53 specific)		$104.50
1597	Aurora A inhibitor I	Aurora A inhibitor		$137.50
1625	GSK579289A	PLK1 Inhibitor		$121.00
1626	GSK 461364 analogue II	PLK1 Inhibitor		$143.00
1630	Aurora A inhibitor II	Aurora A inhibitor		$137.50
1643	HLI 373	HDM2 inhibitor		$110.00
1880	Nutlin-3a	Inhibitor of MDM2		$104.50
1881	Nutlin-3b	Less potent (+)-enantiomer of Nutlin-3		$99.00
1904	SMER 3	Inhibitor of an SCF family E3 Ubiquitin ligase		$99.00
1910	MLN0905	PLK1 inhibitor		$104.50
1953	PRT 4165	E3 Ubiquitin ligase Bmi1/Ring1A inhibitor		$77.00
1961	MK 5108	Inhibitor of Aurora A kinase		$121.00
2003	MLN8237	Second generation selective Aurora A inhibitor		$99.00
2008	Tenovin 1	Activates p53 through inhibition of SIRT 1 and 2		$77.00
2009	RITA	Activates p53 through inhibition of MDM2		$115.50
2164	SJ 172550	Small molecule inhibitor of MDMX		$104.50
2249	Tenovin 6	Small water soluble p53 activator and SIRT inhibitor		$115.50
2437	SP 141	Specific MDM2 inhibitor with therapeutic effects in breast cancer models		$132.00
1538	JNJ 26854165	HDM2 inhibitor		$115.50
1586	JNJ 26854165 dihydrochloride	HDM2 inhibitor		$115.50
2950	Rigosertib sodium	Non-ATP-competitive PLK1 inhibitor		$104.50
4007	NMS-1286937	Orally bioavailable PLK1 inhibitor		Inquire
4192	(S)-BI 2536	Dual PLK1/BRD4 bromodomain inhibitor		$187.00
3918	CZS-241 hydrochloride	Highly potent, selective, and orally available PLK4 inhibitor	Recently added	$176.00

成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Customer Support

Customer Services

About Axon Medchem

Contact Us

GSK 461364

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Customer Support

Customer Services

About Axon Medchem

Contact Us

GSK 461364

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us