AT 9283

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2219

CAS [896466-04-9]

MF C19H23N7O2
MW 381.43

Purity: 99%
Soluble in water and DMSO

AT 9283

Description

A multitargeted kinase inhibitor with high affinity for Aurora A and B, JAK2/3, and BCR-Abl(T315I) (IC50 values 3, 3, 1.2, 1.1, and 4 nM respectively). AT 9283 has a potent anti-proliferative activity in a panel of Ba/F3 and human cell lines expressing the BCR-Abl fusion protein or its mutant forms including T315I, and it has the potential to signi?cantly bene?t patients with imatinib-resistant CML or with Ph+ ALL.

W. Qi et al. AT9283, a novel aurora kinase inhibitor, suppresses tumor growth in aggressive B-cell lymphomas. Int. J. Cancer. 2012, 130, 2997-3005.

R. Tanaka et al. Activity of the multitargeted kinase inhibitor, AT9283, in imatinib-resistant BCR-ABL-positive leukemic cells. Blood. 2010, 116, 2089-2095.

Cell Cycle Regulation Cell Signaling & Oncology Epigenetics Immunology Pain & Inflammation BCR-ABL JAK-STAT EC 2.7.10.2 Aurora JAK

Multitargeted kinase inhibitor (Aurora A/B, JAK2/3, and BCR-Abl)

Chemical name

1-cyclopropyl-3-(3-(6-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea

Parent CAS No.

[896466-04-9]

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5 mg	$93.50	In Stock
25 mg	$324.50	In Stock

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Size	Unit Price	Stock
2 x 5 mg	$143.00	In Stock
2 x 25 mg	$528.00	In Stock

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