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Axon 2407
CAS [86030-08-2]
MF C12H8ClNO4SMW 297.71
The first small molecule reversible inhibitor of the mitotic motor protein Kif18A (IC50 value 1.69 µM for inhibition of Kif18A ATPase activity) that acts in an ATP-competitive and microtubule (Mt) uncompetitive manner.
BTB-1 (aka NSC 156750 or NSC 658180) was previously tested and found to inhibit HIV-1 replication (IC50 value 29.2 µM in cellular anti-HIV-1 assay), yet BTB1 proved to be cytotoxic at low micromolar concentrations.
4-chloro-2-nitro-1-(phenylsulfonyl)benzene
[86030-08-2]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
Download the Axon Ligands™ catalogue 2021 Spring Edition
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