KU-55933

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1367

CAS [587871-26-9]

MF C21H17NO3S2
MW 395.49

Purity: 99%
Soluble in DMSO

KU-55933

Description

Potent, ATP-competitive and selective ATM inhibitor (Ki = 2.2 nM, IC50 = 13 nM)

I Hickson et al. Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM. Cancer Res. 2004, 64, 9152.

A Lau et al. Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase. Nat. Cell Biol. 2005, 7, 493-500.

Y Li and DQ Yang. The ATM Inhibitor KU-55933 Suppresses Cell Proliferation and Induces Apoptosis by Blocking Akt In Cancer Cells with Overactivated Akt.
Mol. Cancer Ther. 2010, 9, 113.

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology ATM p53-Tumor Suppression PI3K-Akt-mTOR DNA-damage Response EC 2.7.11.1

ATM inhibitor

Chemical name

2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one

Parent CAS No.

[587871-26-9]

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10 mg	$121.00	In Stock
50 mg	$363.00	In Stock

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Size	Unit Price	Stock
2 x 10 mg	$176.00	In Stock

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KU-55933

Description

Chemical name

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