Tofacitinib citrate - CP 690550-10

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2072

CAS [540737-29-9]

MF C16H20N6O.C6H8O7
MW 504.49

Purity: 99%
Soluble in DMSO

Tofacitinib citrate

Description

Potent Janus Kinase 3 (JAK3) inhibitor; an immunosuppressive agent exhibiting potent effects in preclinical transplantation and arthritis models; clinically safe and effective in preventing transplant rejection and improving symptoms of rheumatoid arthritis and psoriasis; the citrate salt form of CP 690550 - Tofacitinib (Axon 1338)

AC Papageorgiou et al. Is JAK3 a new drug target for immunomodulation-based therapies? Trends Pharmacol. Sci. 2004, 25(11), 558-562.

E Kudlacz et al. The novel JAK-3 inhibitor CP-690550 is a potent immunosuppressive agent in various murine models. Am. J. Transplant. 2004, 4, 51-57.

E Kudlacz et al. The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia. Eur. J. Pharmacol. 2008, 582, 154-161.

PS Changelian et al. Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor. Sci. 2003, 302(5646), 875-878.

Cell Signaling & Oncology Epigenetics Immunology Pain & Inflammation Immunomodulator JAK-STAT EC 2.7.10.2 JAK

Potent Janus Kinase 3 (JAK3) inhibitor

Chemical name

3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile 2-hydroxypropane-1,2,3-tricarboxylate

Parent CAS No.

[477600-75-2]

Order

Size	Unit Price	Stock
10 mg	$126.50	In Stock
50 mg	$423.50	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description
1338	CP 690550	JAK3 inhibitor	$66.00
1378	AG 490	JAK2 inhibitor	$71.50
1588	TG 101348	JAK2 inhibitor	$88.00
1598	Ruxolitinib	JAK1 and JAK2 inhibitor	$71.50
1681	Momelotinib	JAK1 and JAK2 inhibitor	$88.00
1778	AZ 960	JAK2 inhibitor	$104.50
1843	JAK2 inhibitor 13	JAK2 inhibitor	$121.00
1955	Baricitinib	Inhibitor of JAK1 and JAK2	$77.00
1992	AS 1517499	Potent and selective STAT6 inhibitor	$143.00
2217	PF 956980	JAK3 inhibitor; analogue of Axon 1338 and 2072	$99.00
2219	AT 9283	Multitargeted kinase inhibitor (Aurora A/B, JAK2/3, and BCR-Abl)	$93.50
2231	XL 019	JAK2 inhibitor	$110.00
2314	Stattic	Nonpeptidic small-molecule inhibitor of STAT3 activation, dimerization, and nuclear translocation	$55.00
2316	WP 1066	Potent JAK2 and STAT3 inhibitor and downregulator of antiapoptotic proteins	$104.50
2313	S3I 201	Potent, cellular STAT3 inhibitor	$99.00
2377	Vidofludimus	Oral immunomodulatory drug that inhibits dihydroorotate dehydrogenase (DHODH)	$137.50
2517	Napabucasin	Oral first-in-class cancer stemness inhibitor that works by targeting STAT3	$115.50
2539	Solcitinib	Selective JAK1 inhibitor for treatment of degenerative and inflammatory diseases	$99.00
2554	LY 2784544	Potent, selective and ATP-competitive inhibitor of mutated janus kinase 2 (JAK2V617F)	$104.50
2868	Roquinimex	Immunomodulator	$137.50
2792	NVP-BSK805	Potent, selective and orally bioavailable JAK2 inhibitor	$137.50
2775	Cerdulatinib	Orally active dual Syk/JAK inhibitor	$93.50
3307	Pidotimod	Orally bioavailable immunostimulant	$55.00
3861	Decernotinib	Potent and selective,orally bioavailable Janus kinase 3 (JAK3) inhibitor	Inquire
3950	Peficitinib	Potent and orally bioavailable JAK inhibitor	$132.00
3997	ASN-002	Potent dual inhibitor of SYK and pan-JAK kinases	Inquire
4006	GLPG-0634	The first orally-available, selective inhibitor of JAK1	Inquire
4124	Momelotinib hydrochloride	JAK1 and JAK2 inhibitor	$132.00

成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Customer Support

Customer Services

About Axon Medchem

Contact Us

Tofacitinib citrate - CP 690550-10

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Customer Support

Customer Services

About Axon Medchem

Contact Us

Tofacitinib citrate - CP 690550-10

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us