Saracatinib - AZD0530

Based on 668 reference(s) in Google Scholar 8 10 668

Axon 3284

CAS [379231-04-6]

MF C27H32ClN5O5
MW 542.03

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

Saracatinib

Description

An orally bioavailable tyrosine kinase inhibitor, specifically targeting Src and Abl, those kinases often overexpressed in chronic myeloid leukema cells.

Water-soluble form AZD0530 difumarate is available as Axon 1456.

KEYWORDS: Saracatinib | supplier | Src-Abl inhibitor | AZD0530 | AZD-0530 | AZD 0530 | CAS [379231-04-6] | [893428-72-3] | [893428-71-2] | Non Selective | SRC | ABL | Inhibitor | Enzymes

H Laurent et al. N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor. J. Med. Chem. 2006, 49, 6465.

YM Chang et al. Src family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530. Oncogene 2008, 1–11.

PM Gwanmesia et al. The effect of the dual Src/Abl kinase inhibitor AZD0530 on Philadelphia positive leukaemia cell lines. BMC Cancer 2009, 9, 53.

TP Green et al. Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530. Molecular Oncology 2009, 3(3), 248-261.

C Dulsat et al. Saracatinib. Drugs Fut. 2009, 34(2), 106.

Cell Signaling & Oncology SRC ABL EC 2.7.10.2

Inhibitor of SRC and ABL tyrosine kinases

Chemical name

N-(5-chlorobenzo[d][1,3]dioxol-4-yl)-7-(((4-methylpiperazin-1-yl)methoxy)methyl)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine

Parent CAS No.

[379231-04-6]

Order

Size	Unit Price	Stock
10 mg	$77.00	In Stock
50 mg	$154.00	In Stock

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成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

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Saracatinib - AZD0530

Description

Chemical name

Parent CAS No.

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