Linezolid - Zyvox | PNU 100766 | U 100766

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2048

CAS [165800-03-3]

MF C16H20FN3O4
MW 337.35

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

Linezolid

Description

Protein synthesis inhibitor; antibiotic; stops the growth of bacteria by disrupting their production of proteins; inhibits the ribosomal peptidyltransferase; antibacterial agent for the treatment of multidrug-resistant gram-positive bacterial infections

SJ Brickner et al. Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. J. Med. Chem. 2008, 51(7), 1981-1990.

MR Barbachyn, CW Ford. Oxazolidinone structure-activity relationships leading to linezolid. Angew. Chem. Int. Ed. Engl. 2003, 42(18), 2010-23.

SJ Brickner et al. Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections. J. Med. Chem. 1996, 39(3), 673-9.

U Patel et al. Oxazolidinones mechanism of action: inhibition of the first peptide bond formation. J. Biol. Chem. 2001, 276(40), 37199-205.

CE Barry and JS Blanchard. The Chemical Biology of New Drugs in Development for Tuberculosis. Curr. Opin. Chem. Biol. 2010, 14(4), 456–466.

Immunology EC 2.3.2.12 Peptidyl Transferase Antibiotics Infectious Disease

Protein synthesis inhibitor; antibiotic

Chemical name

(S)-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

Parent CAS No.

[165800-03-3]

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10 mg	$88.00	In Stock
50 mg	$264.00	In Stock

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Parent CAS No.

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Linezolid - Zyvox | PNU 100766 | U 100766

Description

Chemical name

Parent CAS No.

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