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AGI 6780

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2274

CAS [1432660-47-3]

MF C21H18F3N3O3S2
MW 481.51

  • Purity: 99%
  • Soluble in DMSO

AGI 6780

Description

Inhibitor of isocitrate dehydrogenases (IDH) selective for mutant IDH2. AGI 6780 potently and selectively inhibits the tumor-associated mutant IDH2/R140Q (EC50 value <20 nM for reduction of 2HG levels in cell lines) in an allosteric manner at the dimer interface, and induces differentiation of TF-1 erythroleukemia and primary human acute myelogenous leukemia cells in vitro.
Potent and selective inhibitor of the tumor-associated mutant IDH2 (R140Q)

Chemical name

N-cyclopropyl-4-(thiophen-3-yl)-3-(3-(3-(trifluoromethyl)phenyl)ureido)benzenesulfonamide

Parent CAS No.

[1432660-47-3]

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5 mg $99.00 In Stock
25 mg $352.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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