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JNK-IN-8 - JNK Inhibitor XVI

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2361

CAS [1410880-22-6]

MF C29H29N7O2
MW 507.59

  • Purity: 98%
  • Soluble in DMSO

JNK-IN-8

Description

Remarkably potent and selective covalent inhibitor of JNK (IC50 values 4.67 nM, 18.7 nM, and 0.98nM for JNK1/2/3, respectively). JNK-IN-8 inhibits phosphorylation of c-Jun, a direct substrate of JNK, in cells exposed to submicromolar drug in a manner that depends on covalent modification of the conserved cysteine residue (EC50 values 486 nM and 338 nM for inhibition of c-Jun phosphorylation in HeLa and A375 cells, respectively). Useful as a pharmacological probe of JNK-dependent signal transduction
Remarkably potent and selective covalent inhibitor of JNK

Chemical name

3-(4-(dimethylamino)but-2-enamido)-N-(3-methyl-4-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)benzamide

Parent CAS No.

[1410880-22-6]

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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