AZ 20

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2345

CAS [1233339-22-4]

MF C21H24N4O3S
MW 412.51

Purity: 99%
Optical purity: Optically pure
Soluble in 0.1N HCl(aq) and DMSO

AZ 20

Description

Potent, orally active and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity (IC50 value 5 nM). AZ 20 potently inhibits the growth of LoVo colorectal adenocarcinoma tumor cells in vitro, and is a useful compound to explore ATR pharmacology in vivo.

K.M. Foote et al. Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy.... J. Med. Chem. 2013, 56, 2125-2138.

M.R. Finlay et al. Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family. Bioorg. Med. Chem. Lett. 2012, 22, 5352-5359.

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology ATR p53-Tumor Suppression PI3K-Akt-mTOR DNA-damage Response EC 2.7.11.1

Potent, orally active and selective inhibitor of ATR protein kinase

Chemical name

(R)-4-(2-(1H-indol-4-yl)-6-(1-(methylsulfonyl)cyclopropyl)pyrimidin-4-yl)-3-methylmorpholine

Parent CAS No.

[1233339-22-4]

Order

Size	Unit Price	Stock
5 mg	$115.50	In Stock
25 mg	$423.50	In Stock

Special Offers

Size	Unit Price	Stock
2 x 5 mg	$187.00	In Stock
2 x 25 mg	$660.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description
1281	BEZ 235	PI3K and mTOR tyrosine kinase inhibitor	$55.00
1282	BAG 956	PI3K and PDPK1 inhibitor	$104.50
1334	PIK 75 hydrochloride	PI3K inhibitor (p110-α specific)	$77.00
1362	PIK 90	PI3K inhibitor (p110-α specific)	$93.50
1366	LY 294002	PI3K inhibitor	$77.00
1367	KU-55933	ATM inhibitor	$121.00
1377	GDC 0941 bismesylate	PI3K inhibitor	$88.00
1380	PI 103 hydrochloride	PI3K inhibitor (p110 specific)	$66.00
1417	TGX 221	PI3K inhibitor (p110 β specific)	$77.00
1424	AS 252424	PI3K inhibitor (p110-γ specific)	$93.50
1463	NU 7441	DNA-PK inhibitor	$44.00
1495	CP 466722	ATM inhibitor	$77.00
1520	NVP-BBD130	Dual PI3K and mTOR kinase inhibitor	$137.50
1584	KU-0060648 trihydrochloride	DNA-PK inhibitor	Inquire
1596	GSK 2126458	Dual PI3K and mTOR inhibitor	$55.00
1706	XL PI3K/mTOR inhibitor	Dual PI3K and mTOR kinase inhibitor	$132.00
1719	D 106669	Potent and selective PI3K inhibitor	$93.50
1782	GDC 0980	Dual PI3K and mTOR inhibitor	$88.00
1797	NVP-BKM120	Class I PI3K inhibitor	$99.00
1807	PKI 587	Dual PI3K and mTOR inhibitor	$99.00
1831	A 66	PI3K inhibitor (p110-α specific)	$104.50
1855	PF 04691502	PI3K and mTOR tyrosine kinase inhibitor	$99.00
1893	VE 821	Inhibitor of the DNA damage response kinase ATR	$88.00
1912	GSK 2636771 dihydrochloride	PI3K inhibitor (p110 β specific)	$115.50
2029	NVP-BGT226	Orally active dual PI3K/mTOR inhibitor	$132.00
2039	CZC 24832	PI3K inhibitor (p110-γ specific)	$104.50
2170	CAL 101	PI3K inhibitor (p110 δ specific)	$104.50
2168	IC 87114	Potent and highly selective inhibitor of the PI3K p110δ	$93.50
1436	AS 252424 bispotassium salt	PI3K inhibitor (p110-γ specific)	$104.50
2390	HAMNO	Novel protein interaction inhibitor of replication protein A (RPA)	$93.50
2452	VE 822	Selective ATR inhibitor that decreases survival of pancreatic cancer cells	$121.00
2604	KU-0060648	DNA-PK inhibitor	$148.50
2918	BAY 1895344	Potent, orally available and highly selective inhibitor of ATR protein kinase	$110.00
3134	AZD6738	Potent, selective, orally active and bioavailable ATR kinase inhibitor	$121.00

成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Customer Support

Customer Services

About Axon Medchem

Contact Us

AZ 20

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Customer Support

Customer Services

About Axon Medchem

Contact Us

AZ 20

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us