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Featured Products
Axon 1733
CAS [1204669-58-8]
MF C11H13BrFN7O4SMW 438.23
Potent competitive inhibitor of indoleamine 2,3-dioxygenase (IDO1, IC50 value 72 nM in vitro) with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model; INCB024360 (Epacadostat) decreased kynurenine levels by >50% in plasma and inhibited B16-GM-CSF tumor growth in a dose dependent fashion.
An analog of INCB 024360 (Axon 2215) is available as well.
KEYWORDS: INCB 24360 | IDO1 inhibitor | Axon 1733 | Epacadostat | INCB 024360 | INCB024360 | INCB24360 | CAS [1204669-58-8] | [1204669-37-3] | Kynurenine | cancer | immunotherapy | melanoma | hydroxamidine
(Z)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-(2-(sulfamoylamino)ethylamino)-1,2,5-oxadiazole-3-carboximidamide
[1204669-58-8]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
Download the Axon Ligands™ catalogue 2021 Spring Edition
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