BIX 02189

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1809

CAS [1094614-85-3]

MF C27H28N4O2
MW 440.54

Purity: 99%
Soluble in DMSO

BIX 02189

Description

Selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively.

BIX02189 is a close analogue of BIX02188-Me (Axon 1808) and BIX02188 (Axon 3346).

KEYWORDS: BIX02189 | supplier | MEK5/ERK5 inhibitor | BIX 02189 | BIX-02189 | CAS [1094614-85-3] | 1265916-41-3 (Z-isomer) | MAPK | MEK | ERK | Inhibitor | Enzymes

RJ Tatake et al. Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem. Biophys. Res. Comm. 2008, 377(1), 120–125.

Y Obara and N Nakahata. The signaling pathway leading to extracellular signal-regulated kinase 5 (ERK5) activation via G-proteins and ERK5-dependent neurotrophic effects. Mol. Pharmacol. 2010, 77(1), 10-16.

BA Drew, ME Burowa , BS Beckman. MEK5/ERK5 pathway: The first fifteen years. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2012, 1825 (1), 37-48.

Cell Signaling & Oncology Stem Cell MAPK EC 2.7.12.2 ERK MEK

MEK5 inhibitor; ERK5 inhibitor

Chemical name

((3-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide

Parent CAS No.

[1094614-85-3]

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Size	Unit Price	Stock
5 mg	$121.00	In Stock
25 mg	$385.00	In Stock

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Size	Unit Price	Stock
2 x 5 mg	$176.00	In Stock
2 x 25 mg	$616.00	In Stock

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BIX 02189

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Parent CAS No.

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成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

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BIX 02189

Description

Chemical name

Parent CAS No.

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