Brassinin

Based on 88 publications in PubMed 10 10 88

Axon 2489

CAS [105748-59-2]

MF C11H12N2S2
MW 236.36

Purity: 98%
Soluble in DMSO

Brassinin

Description

Bioavailable dithiocarbamate with affinity for indoleamine 2,3-dioxygenase (IDO; Ki value 28 μM for human IDO) showing antifungal and anticancer activity. Moreover, Brassinin suppressed both constitutive and IL-6-inducible STAT3 activation through modulation of PIAS-3 and SOCS-3, thereby attenuating tumor growth and increasing sensitivity to paclitaxel.

T. Banerjee et al. A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase. Oncogene. 2008 May 1;27(20):2851-7.

P. Gaspari et al. Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2006 Jan 26;49(2):684-92.

J.H. Lee et al. Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel. Oncotarget. 2015 Mar 20;6(8):6386-405.

Apoptosis Cell Signaling & Oncology Immunology IDO Transcription Factors JAK-STAT TF class 4.2.1 EC 1.13.11.52 STAT3 Infectious Disease

Dual IDO1/STAT3 inhibitor with antifungal and anticancer activity

Chemical name

methyl (1H-indol-3-yl)methylcarbamodithioate

Parent CAS No.

[105748-59-2]

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10 mg	$82.50	In Stock
25 mg	$110.00	In Stock

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Brassinin

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