PF 04691502

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1855

CAS [1013101-36-4]

MF C22H27N5O4
MW 425.48

Purity: 99%
Soluble in DMSO

PF 04691502

Description

Potent, selective, oral and ATP-competitive inhibitor of class I PI3K (Ki: 1-2 nM) and mTOR kinases (Ki: 16 nM); it inhibits PI3K/mTOR signaling and induces cell cycle arrest in cancer cells

J Yuan et al. PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity. Mol. Cancer Ther. 2011, 10, 2189.

H Cheng et al. Discovery of the highly potent PI3K/mTOR dual inhibitor PF-04691502 through structure based drug design. Med. Chem. Commun. 2010, 1, 139-144.

Cell Cycle Regulation Cell Signaling & Oncology PI3K mTOR PI3K-Akt-mTOR EC 2.7.11.1

PI3K and mTOR tyrosine kinase inhibitor

Chemical name

2-amino-8-((1r,4r)-4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one

Parent CAS No.

[1013101-36-4]

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Size	Unit Price	Stock
5 mg	$99.00	In Stock
25 mg	$319.00	In Stock

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Size	Unit Price	Stock
2 x 5 mg	$154.00	In Stock
2 x 25 mg	$506.00	In Stock

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PF 04691502

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