AZD8055

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1561

CAS [1009298-09-2]

MF C25H31N5O4
MW 465.54

Purity: 99%
Optical purity: Optically pure
Soluble in 0.1N HCl(aq) and DMSO

AZD8055

Description

Potent and selective mTOR inhibitor, with IC50 values to be 0.8 nM and selectivity ca 1000-fold against class I PI3K and other PIKKs

CM Chresta et al. AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity. Cancer Res. 2010, 70(1), 288-298.

P Sini et al. Simultaneous inhibition of mTORC1 and mTORC2 by mTOR kinase inhibitor AZD8055 induces autophagy and cell death in cancer cells. Autophagy. 2010, 6(4).

Cell Signaling & Oncology Stem Cell mTOR PI3K-Akt-mTOR EC 2.7.11.1

mTOR inhibitor

Chemical name

(5-(2,4-bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol

Parent CAS No.

[1009298-09-2]

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Size	Unit Price	Stock
5 mg	$88.00	In Stock
25 mg	$264.00	In Stock

Special Offers

Size	Unit Price	Stock
2 x 5 mg	$132.00	In Stock
2 x 25 mg	$396.00	In Stock

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AZD8055

Description

Chemical name

Parent CAS No.

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