Vadadustat - AKB6548 | PG-1016548

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 3288

CAS [1000025-07-9]

MF C14H11ClN2O4
MW 306.70

Purity: 99%
Soluble in 0.1N NaOH(aq) and DMSO

Vadadustat

Description

Vadadustat is a titratable, oral HIF prolyl-4-hydroxylase (HIF-PH) inhibitor and HIF stabilizer.

KEYWORDS: Vadadustat | supplier | HIF-PH inhibitor | AKB6548 | PG-1016548 | AKB 6548 | AKB-6548 | PG1016548 | PG 1016548 | CAS [1000025-07-9] | Hypoxia-signaling cascade | PHD-2 (HIF1) | Inhibitor | Enzymes | Anemia | Chronic kidney disease | CKD

PE Pergola et al. Vadadustat, a novel oral HIF stabilizer, provides effective anemia treatment in nondialysis- dependent chronic kidney disease. Kidney Int 2016 Nov;90(5):1115-1122.

AA Joharapurkar et al. Prolyl Hydroxylase Inhibitors: A Breakthrough in the Therapy of Anemia Associated with Chronic Diseases. J Med Chem 2018 Aug 23;61(16):6964-6982.

Angiogenesis Apoptosis Cell Signaling & Oncology Epigenetics PHD (HIF) Transcription Factors EC 1.14.11.29

Oral HIF-PH inhibitor and HIF stabilizer

Chemical name

2-(5-(3-Chlorophenyl)-3-hydroxypicolinamido)acetic acid

Parent CAS No.

[1000025-07-9]

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Size	Unit Price	Stock
10 mg	$88.00	In Stock
50 mg	$297.00	In Stock

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