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CAS No. : | 958230-19-8 | MDL No. : | MFCD09859124 |
Formula : | C8H5ClN2O | Boiling Point : | No data available |
Linear Structure Formula : | - | InChI Key : | SVRMXFJXIGCKII-UHFFFAOYSA-N |
M.W : | 180.59 | Pubchem ID : | 24229274 |
Synonyms : |
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Signal Word: | Warning | Class: | |
Precautionary Statements: | P305+P351+P338 | UN#: | |
Hazard Statements: | H302-H319 | Packing Group: | |
GHS Pictogram: |
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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
91% | With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In 1,4-dioxane; water; at 100℃; for 14h; | [0302] 1,4-Dioxane (20 mL), a 2 M aqueous solution of sodium carbonate (6 mL) and Pd(PPh3)4 (318 mg) were addedto 4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde (1.00 g) and the compound of Reference Example 1(2a) (1.96 g),and the temperature of the obtained mixture was then increased to 100C, followed by stirring for 14 hours. Thereafter,water was added to the reaction mixture for dilution, and the obtained mixture was then extracted with chloroform. Thegathered organic layer was washed with a saturated saline, dried over anhydrous sodium sulfate, and then concentratedunder a reduced pressure. The obtained residue was purified by silica gel chromatography (chloroform : methanol) toobtain a product of interest (1.70 g, yield: 91%).ESI-MS m/z 342(MH+) |
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