Medetomidine
Catalog No.
A3592
α2-adrenoceptor agonist
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Medetomidine is a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). Medetomidine displays greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Medetomidine inhibits twitch response in electrically stimulated mouse vas deferens (pD2 = 9.0). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.
- 1. Bai L, Mesgarzadeh S, et al. "Genetic Identification of Vagal Sensory Neurons That Control Feeding." Cell. 2019 Nov 14;179(5):1129-1143.e23. PMID:31730854
- 2. Christopher A. Zimmerman. "The neural basis of thirst." UNIVERSITY OF CALIFORNIA. 2019.
- 3. Leib DE, Zimmerman CA, et al. "The Forebrain Thirst Circuit Drives Drinking through Negative Reinforcement." Neuron. 2017 Dec 20;96(6):1272-1281.e4. PMID:29237758
| Storage | Store at -20°C |
| M.Wt | 200.28 |
| Cas No. | 86347-14-0 |
| Formula | C13H16N2 |
| Synonyms | Domtor |
| Solubility | ≥34.5 mg/mL in DMSO; ≥19.3 mg/mL in EtOH; insoluble in H2O |
| Chemical Name | 5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole |
| SDF | Download SDF |
| Canonical SMILES | CC1=C(C)C(C(C2=CN=CN2)C)=CC=C1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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