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Home
Veratridine

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Signaling Pathways
Membrane Transporter/Ion Channel
Sodium Channel
Veratridine

Veratridine

Catalog No.

B7219

Voltage-gated Na+ channel opener

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Grouped product items
Size	Price	Stock	Qty
10mg	$359.00	Ship with 5-10 days
50mg	$963.00	Ship with 5-10 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Chemical Properties
Protocol
Quality Control

Chemical Properties

Physical Appearance	White solid
Storage	Store at -20°C
M.Wt	673.79
Cas No.	71-62-5
Formula	C₃₆H₅₁NO₁₁
Solubility	<33.69mg/ml in DMSO
Chemical Name	(3S,4S,4aS,6aS,6bS,8R,8aS,9S,9aS,12S,15aS,15bR,16aR,16bR)-4,6b,8,8a,9,15b-hexahydroxy-9,12,16b-trimethyldocosahydro-1H-4,16a-epoxybenzo[4,5]indeno[1,2-h]pyrido[1,2-b]isoquinolin-3-yl 3,4-dimethoxybenzoate
SDF	Download SDF
Canonical SMILES	O[C@@]([C@@]1([C@H](CN2[C@H]3CC[C@H](C)C2)[C@]4([C@@]3(C)O)O)O)(C[C@H]4O)[C@H]5[C@@]([C@@](CC[C@@H]6OC(C(C=C7OC)=CC=C7OC)=O)(C)[C@@H]8CC5)(C1)O[C@@]86O
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment [1]:
Cell lines	HCT-116 colon cancer cells (expressing GFP-UBXN2A)
Preparation method	The solubility of this compound in DMSO is >10mM. General tips for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.
Reacting condition	20 and 40 μM, 24 hours
Applications	Veratridine is the main UBXN2A enhancer, increased UBXN2A protein levels in a dose-dependent manner.
Animal experiment [2]:
Animal models	C57Bl/6N mice( HCT-116 cells expressing GFP-UBXN2A were injected into 6 to 8 week old nude　female mice)
Dosage form	Intraperitoneal injection (IP), 0.125 mg/kg for 28 days
Application	Veratridine (VTD) was sufficient to induce UBXN2A protein levels, resulting in colon cancer cell death in UBXN2A- and mot-2-dependent manners.
Other notes	Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.
References: [1]. Abdullah A, Sane S, Branick KA，et al.A plant alkaloid, veratridine, potentiates cancer chemosensitivity by UBXN2A-dependent inhibition of an oncoprotein, mortalin-2. Oncotarget. 2015 Sep 15;6(27):23561-81.

Quality Control

Quality Control & MSDS

View current batch:

Purity = 98.00%

COA (Certificate Of Analysis)
MSDS (Material Safety Data Sheet)

Chemical structure

Veratridine

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