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Home
Ouabain

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Signaling Pathways
Membrane Transporter/Ion Channel
Sodium Channel
Ouabain

Ouabain

Catalog No.

B2270

selective Na+/K+-ATPase inhibitor

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Grouped product items
Size	Price	Stock	Qty
50mg	$105.00	In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background
Product Citation
Chemical Properties
Protocol
Quality Control

Background

Ouabain is a selective Na+/K+, -ATPase inhibitor, binds to α2 /α3 subunit with K_i of 41 nM/15 nM.

Product Citation

1. Vanessa Smer-Barreto, Andrea Quintanilla, et al. "Discovery of senolytics using machine learning." Nat Commun. 2023 Jun 10;14(1):3445. PMID: 37301862

Chemical Properties

Storage	Store at -20°C
M.Wt	728.77
Cas No.	630-60-4
Formula	C₂₉H₄₄O₁₂·8H₂O
Solubility	≥72.9 mg/mL in DMSO
Chemical Name	3-[(1R,3S,5S,8R,9S,10R,11R,13R,14S,17R)-1,5,11,14-tetrahydroxy-10-(hydroxymethyl)-13-methyl-3-[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2H-furan-5-one
SDF	Download SDF
Canonical SMILES	CC1C(C(C(C(O1)OC2CC(C3(C4C(CCC3(C2)O)C5(CCC(C5(CC4O)C)C6=CC(=O)OC6)O)CO)O)O)O)O
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment:[1]
Cell lines	Rat astrocytes
Reaction Conditions	0.1 ~ 1 μM ouabain
Applications	In cultured rat astrocytes, 0.1 ~ 1 μM of ouabain inhibited the Na⁺ pump and increased stored Ca²⁺. As an inhibitor of the Na⁺ pump, ouabain could be used to explore the distribution and function of the isoforms of the Na⁺ pump catalytic (α) subunit due to its different affinity for each isoform.
Animal experiment:[2]
Animal models	Male Wistar rats with heart failure due to myocardial infarction (MI)
Dosage form	14.4 mg/kg/day Injected subcutaneously (s.c.) for 2 weeks; either continuously (osmotic minipumps) or intermittently (once daily)
Applications	Ouabain (14.4 mg/kg/day; s.c.; intermittent) further increased total peripheral resistance (TPR) in rats with heart failure due to MI, while continuous ouabain treatment normalized TPR in MI rats. Ouabain (14.4 mg/kg.d; s.c.; continuous) significantly improved basal and maximal CO.
Note	The technical data provided above is for reference only.
	References: 1. Juhaszova M, Blaustein MP. Na+ pump low and high ouabain affinity alpha subunit isoforms are differently distributed in cells. Proceedings of the National Academy of Sciences of the United States of America, 1997, 94(5): 1800-1805. 2. Nelissen-Vrancken HJ, Wang JF, Struijker Boudier HA, et al. Ouabain improves cardiac function in vivo in rats with heart failure after chronic but not acute treatment. Naunyn-Schmiedeberg's Archives of Pharmacology, 1997, 356(2): 203-209.

Quality Control

Quality Control & MSDS

View current batch:

Purity = 98.00%

Chemical structure

Ouabain

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