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In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Cell lines
Chinese hamster ovary cell CHO
Preparation method
The solubility of this compound in DMSO is ≥9.6 mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.
Reacting condition
25, 50, 100 and 200 μg/ml
Applications
In the absence of the S-9 mixture, as the concentration of nitrofurazone increased, the major trends of chromosomal gaps, breaks and swaps in CHO cells increased. The incidence of chromatid damage was also increased in cells treated with nitrofurazone, but there was no significant dose correlation. In the presence of a mixture of S-9, an increase in chromosomal damage was accompanied by an increase in the dose correlation of chromatid breaks and interchanges.
Animal models
Male rats
Dosage form
40,120 and 400 mg/kg (administration by gavage)
Application
After nitrofurazone treatment, there was no evidence of any increase in the percentage of cell aberrations, the average number of chromosomal aberrations, or the number of animal abnormalities at any sampling time (single or five doses per day).
Other notes
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.
References:
[1]. Kong D, Yun H, Cui D, Qi M, Shao C, Cui D, Ren N, Liang B, Wang A. Response of antimicrobial nitrofurazone-degrading biocathode communities to different cathode potentials. Bioresour Technol. 2017 Oct; 241:951-958. doi:10.1016/j.biortech.2017.06.056. Epub 2017 Jun 13. PubMed PMID: 28637162.
