IOX 1
IOX 1 (5-carboxy-8HQ) is an inhibitor of histone demethylase JMJD with IC50 values of 0.2 μM for JMJD2E [1].
The Jumonji domain (JMJD) is a histone demethylase and acts as a transcriptional repressor.
IOX 1 is a histone demethylase JMJD inhibitor. In the FDH-coupled assay, IOX 1 inhibited JMJD2E with IC50 value of 0.2 μM. In MALDI-TOF MS assay, IOX 1 inhibited JMJD2E, JMJD2A, FIH and PHD2 with IC50 values of 2.4, 1.7, 20.5 and 14.3 μM, respectively. In HeLa cells, IOX 1 increased H3K9me3 fluorescence intensity, suggesting that IOX 1 inhibited H3K9me3 demethylation induced by JMJD2A with IC50 value of 86.5 μM. Also, IOX 1 exhibited cytotoxicity with IC50 value of 291.6 μM [1].
Reference:
[1].? King ON, Li XS, Sakurai M, et al. Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. PLoS One, 2010, 5(11): e15535.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 189.17 |
| Cas No. | 5852-78-8 |
| Formula | C10H7NO3 |
| Solubility | insoluble in EtOH; insoluble in H2O; ≥5.75 mg/mL in DMSO |
| Chemical Name | 8-hydroxyquinoline-5-carboxylic acid |
| SDF | Download SDF |
| Canonical SMILES | OC1=C2N=CC=CC2=C(C(O)=O)C=C1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Description | IOX1 is a potent and broad-spectrum inhibitor of 2OG oxygenases. | |||||
| Targets | 2OG oxygenases | |||||
| IC50 | ||||||
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
Related Biological Data
