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In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Quinidine is a clinical antiarrhythmic drug, which is used to treat abnormal heart rhythms and malaria[1].?
The application of quinidine in the bath results in a dose-dependent decrease in the peak amplitude of Ik. Kd for Ik block at 0 mV is estimated to be 41 μM[1].?
In rats, quinidine inhibits metabolism of amphetamine. Quinidine pretreatment significantly reduces excretion of p-hydroxyamphetamine at 24 and 48 hours, to 7.2% and 24.1% of vehicle control levels, and significantly increases excretion of amphetamine between 24 and 48 hours to 542%[2].?
Reference:
[1]. Kehl S J, et al. Quinidine-induced inhibition of the fast transient outward K+ current in rat melanotrophs. Br J Pharmacol, 1991, 103(3): 1807-13.
[2]. Moody D E, et al. Quinidine inhibits in vivo metabolism of amphetamine in rats: impact upon correlation between GC/MS and immunoassay findings in rat urine. J Anal Toxicol, 1990, 14(5): 311-7.
