Tamoxifen Citrate
Tamoxifen Citrate is an antiestrogen drug [1].
Tamoxifen Citrate has been reported to act as an anti-estrogen and inhibit the binding of estrogen to estrogen receptors. Tamoxifen has shown the activity to inhibit tumor growth because of the function of estrogen-antagonist activity in breast tissue. In addition, Tamoxifen has been revealed to inhibit the expression of estrogen-regulated genes, including growth factors and angiogenic factors secreted by the tumor. Tamoxifen has also shown the block in the G1 phase of cell cycle and a slowing cell proliferation. Furthermore, Tamoxifen has been noted to directly induce programmed cell death [1].
References:
[1] Osborne CK. Tamoxifen in the treatment of breast cancer. N Engl J Med. 1998 Nov 26;339(22):1609-18.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 563.64 |
| Cas No. | 54965-24-1 |
| Formula | C32H37NO8 |
| Solubility | ≥28.2 mg/mL in Etoh with gentle warming; insoluble in H2O; ≥97 mg/mL in DMSO |
| Chemical Name | 2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine;2-hydroxypropane-1,2,3-tricarboxylic acid |
| SDF | Download SDF |
| Canonical SMILES | CCC(=C(C1=CC=CC=C1)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
