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In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Ethionamide is part of a group of drugs used in the treatment of drug resistant TB called thioamides. It is used as part of treatment regimens, generally involving 5 medicines, to treat MDR and XDR TB.
Cell lines
HepG2, Caco-2 and RAW macrophages
Preparation method
The solubility of this compound in DMSO is ≥7.65mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.
Reacting condition
0.50 mM
Applications
In HepG2, Caco-2, and RAW macrophages, when Ethionamide concentration is higher than 0.50 mM, it is generally toxic to cells, but when Ethionamide is loaded into microparticles, the toxicity is significantly reduced. In the presence of thermal carbonized-porous silicon (TCPSi) particles, Ethionamide exhibits a rapid metabolic process.
References:
[1]. Vale N, M?kil? E, Salonen J, Gomes P, Hirvonen J, Santos HA. New times, new trends for ethionamide: In vitro evaluation of drug-loaded thermally carbonized porous silicon microparticles. Eur J Pharm Biopharm. 2012 Jun;81(2):314-23. doi: 10.1016/j.ejpb.2012.02.017. Epub 2012 Mar 6. PubMed PMID: 22418076.
