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Oxytocin acetate

Catalog No.
B4723
mammalian neurohypophysial hormone
Grouped product items
SizePriceStock Qty
5mg
$50.00
In stock
10mg
$70.00
In stock
50mg
$125.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

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Background

Oxytocin is a positive allosteric modulator of μ opioid receptor (MOR) signaling [1].?

Oxytocin, a 9-amine neuropeptide synthesized in the paraventricular nucleus (PVN) and the supraoptic nucleus of the hypothalamus, is secreted from the posterior pituitary into the systemic circulation, playing an essential role in mammalian labor, lactation, maternal bonding, and social affiliation. Oxytocin has been reported to exert an?analgesic?effect as well [1].?

In hMOR-expressing HEK293 cells, Oxytocin alone showed no direct agonistic effect on human MOR at concentration up to 10-5 M, but treatment with 10-6 M Oxytocin markedly enhanced the MOR signaling stimulated by 10-6 M endomorphin-1, β-endorphin, morphine, fentanyl, as well as DAMGO. Moreover, in the competitive receptor-binding assay, 10-6 M Oxytocin did not alter the affinity of endomorphin-1 or morphine for MOR [1]. ?

Intracerebroventricular Oxytocin administration (0.2 μg) robustly increased medial nucleus accumbens shell (NAcSh) neuron mean firing rate in rats, but did not do so after rats were repeatedly treated with morphine [2].?

References:

[1]. Meguro Y, Miyano K, Hirayama S, et al. Neuropeptide oxytocin enhances μ opioid receptor signaling as a positive allosteric modulator. Journal of Pharmacological Sciences, 2018, 137(1): 67-75.

[2]. Moaddab M, Hyland B I, Brown C H. Oxytocin excites nucleus accumbens shell neurons in vivo. Molecular and Cellular Neuroscience, 2015, 68: 323-330.

Product Citation

Chemical Properties

StorageStore at -20°C
M.Wt1067.25
Cas No.6233-83-6
FormulaC45H70N12O14S2
Synonymsα-Hypophamine acetate; Oxytocic hormone acetate
Solubility≥182.8 mg/mL in DMSO; ≥14.93 mg/mL in EtOH; ≥44.1 mg/mL in H2O
Chemical Namerac-(R)-N-((R)-1-((2-amino-2-oxoethyl)amino)-4-methyl-1-oxopentan-2-yl)-1-((4S,7R,10R,13R,16R,19S)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-((R)-sec-butyl)-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacyclo
SDFDownload SDF
Canonical SMILESO=C([C@H]1N(C([C@H](CSSC[C@@H]2N)NC([C@H](CC(N)=O)NC([C@H](CCC(N)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC(C=C3)=CC=C3O)NC2=O)=O)=O)=O)=O)=O)CCC1)N[C@H](C(NCC(N)=O)=O)CC(C)C.OC(C)=O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment:[1]

Cell lines

Human Embryonic Kidney 293 (HEK293) cells stably expressing human μ opioid receptor (hMOR)

Reaction Conditions

10-10 ~ 10-5 M oxytocin

Applications

In hMOR-expressing HEK293 cells, oxytocin alone showed no direct agonistic effect on hMOR at concentration up to 10-5 M, but treatment with 10-6 M oxytocin markedly enhanced the MOR signaling stimulated by 10-6 M endomorphin-1, β-endorphin, morphine, fentanyl, as well as DAMGO. Neuropeptide oxytocin could enhance MOR signaling as a positive allosteric modulator.
Animal experiment:[2]

Animal models

Adult male Wistar rats aged 6 ~ 8 weeks and weighing 250 ~ 300 g

Dosage form

0.2 μg

Intracerebroventricular administration

Applications

Intracerebroventricular oxytocin administration (0.2 μg) robustly increased medial nucleus accumbens shell (NAcSh) neuron mean firing rate in rats, but did not do so after rats were repeatedly treated with morphine.

Note

The technical data provided above is for reference only.

References:

1. Meguro Y, Miyano K, Hirayama S, et al. Neuropeptide oxytocin enhances μ opioid receptor signaling as a positive allosteric modulator. Journal of Pharmacological Sciences, 2018, 137(1): 67-75.

2. Moaddab M, Hyland B I, Brown C H. Oxytocin excites nucleus accumbens shell neurons in vivo. Molecular and Cellular Neuroscience, 2015, 68: 323-330.

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