Monoacetylphloroglucinol (MAPG), small molecular weight phenolic metabolite, is produced via bacteria including Pseudomonas strains. MAPG is acetylated to form the broad-spectrum antibiotic, 2,4-diacetylphloroglucinol (DAPG) by MAPG acetyltransferase. In addition, MAPG exerts fairly weak potency when exhibiting a broad range of antibiotic activity. Even though weakly active, it seems that MAPG is essential in the biocontrol of plant diseases by some Pseudomonas strains [1].
In vitro: Up to now, in vitro study of MAPG is still in the development stage.
In vivo: Up to now, in vivo study of MAPG is still in the development stage.
Reference:
[1]. HAYASHI, A., SAITOU, H., MORI, T., MATANO, I., SUGISAKI, H., & MARUYAMA, K. Molecular and Catalytic Properties of Monoacetylphloroglucinol Acetyltransferase fromPseudomonassp. YGJ3. Bioscience, Biotechnology, And Biochemistry. 2012; 76(3): 559-566.
