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In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Fatostatin A is an inhibitor of sterol regulatory element binding protein (SREBP), which can inhibit the activation of SREBP-1 and SREBP-2[1].?
Fatostatin A (0.1-1 μM; 3 days) inhibits the androgen-independent proliferation of prostate cancer cell in a manner independent of the known IGF1 signaling pathway. Fatostatin A inhibits insulin-induced fat formation in 3T3-L1 cells[2].?
Fatostatin A (30 mg/kg; 150 mL; i.p.; daily for 28 days) prevents obese ob/ob mice from increasing their weight, blood sugar, and liver fat accumulation, even if they do not control the food intake of mice[1].?
References:
[1]. Kamisuki S, et al. A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem Biol. 2009, 16(8): 882-92.
[2]. Choi Y, et al. Identification of bioactive molecules by adipogenesis profiling of organic compounds. J Biol Chem. 2003, 278(9): 7320-4.
