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- FH1(BRD-K4477)
FH1(BRD-K4477)
FH1 is a small molecule that can enhance the functions of cultured hepatocytes [1].
FH1 belongs to the function-only hits which are screened out by their ability to permit renewable sourcing of functional human hepatocytes. Besides that, FH1 can promote differentiation of iPS-derived hepatocytes towards a more mature phenotype. It doubles albumin secretion during the differentiation of iPS cells into iHeps. Cultures treated with FH1 contain larger colonies of iHeps were with more pronounced hepatocyte morphologies. Moreover, treatment of FH1 also resulted in the increase of CYP3A4 levels and the decrease of AFP secretion [1].
References:
[1] Shan J, Schwartz R E, Ross N T, et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nature chemical biology, 2013.
- 1. Yuan L, Zhang Y, et al. "Agonist c-Met Monoclonal Antibody Augments the Proliferation of hiPSC-derived Hepatocyte-Like Cells and Improves Cell Transplantation Therapy for Liver Failure in Mice." Theranostics. 2019 Apr 6;9(7):2115-2128. PMID:31037160
- 2. Yuan L, Liu X, et al. "Optimized HepaRG is a suitable cell source to generate the human liver chimeric mouse model for the chronic hepatitis B virus infection." Emerg Microbes Infect. 2018 Aug 10;7(1):144. PMID:30097574
- 3. Yuan L, Liu X, et al. "A Chimeric Humanized Mouse Model by Engrafting the Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cell for the Chronic Hepatitis B Virus Infection." Front Microbiol. 2018 May 8;9:908. PMID:29867819
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 282.34 |
| Cas No. | 2719-05-3 |
| Formula | C17H18N2O2 |
| Solubility | ≥12.25 mg/mL in DMSO with gentle warming |
| SDF | Download SDF |
| Canonical SMILES | CC(=O)NC1=CC=C(C=C1)CC2=CC=C(C=C2)NC(=O)C |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Description | FH1 is a small molecule that can enhance the functions of cultured hepatocytes. | |||||
| Targets | primary human hepatocytes | |||||
| IC50 | ||||||
Quality Control & MSDS
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