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Timolol Maleate

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Signaling Pathways
GPCR/G protein
Adrenergic Receptor
Timolol Maleate

Timolol Maleate

Catalog No.

B1350

Non-selective, beta-adrenergic receptor antagonist

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Grouped product items
Size	Price	Stock	Qty
10mM (in 1mL DMSO)	$54.00	In stock
100mg	$50.00	In stock
250mg	$96.00	In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background
Chemical Properties
Protocol
Quality Control

Background

(S)-Timolol maleate, is a potent non-selective β-adrenergic receptor antagonist (Ki values are 1.97 and 2.0 nM for β1 and β2 receptor subtypes respectively).

Chemical Properties

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	432.49
Cas No.	26921-17-5
Formula	C₁₇H₂₈N₄O₇S
Solubility	≥21.62 mg/mL in DMSO; ≥10.53 mg/mL in EtOH; ≥11.83 mg/mL in H2O
Chemical Name	(Z)-but-2-enedioic acid;(2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
SDF	Download SDF
Canonical SMILES	CC(C)(C)NCC(COC1=NSN=C1N2CCOCC2)O.C(=CC(=O)O)C(=O)O
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Animal experiment:[1]
Animal models	Adult male Wistar rats, 9 weeks of age, 250 ~ 300 g
Dosage form	0.5% timolol maleate Topically applied daily, started 1 week after the laser photocoagulation and lasted for 3 weeks
Applications	In rats subjected to intracameral injection of India ink and subsequent laser trabecular photocoagulation, timolol maleate induced a significant reduction in intraocular pressure (IOP) and counteracted the reduction in retinal ganglion cell (RGC) number that occurred in vehicle treated glaucomatous eyes. Thus, timolol maleate was able to reduce IOP and protected RGCs in a rat model of experimental glaucoma.
Note	The technical data provided above is for reference only.
	References: 1. Seki M, Tanaka T, Matsuda H, et al. Topically administered timolol and dorzolamide reduce intraocular pressure and protect retinal ganglion cells in a rat experimental glaucoma model. British Journal of Ophthalmology, 2005, 89(4): 504-507.

Quality Control

Quality Control & MSDS

View current batch:

Purity = 98.16%

Chemical structure

Timolol Maleate